Browsing Artikler, rapporter og annet (medisinsk biologi) by Author "Bakland, Gunnstein"

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    • Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression 

      Pedersen, Hege Lynum; Horvei, Kjersti Daae; Thiyagarajan, Dhivya; Norby, Gudrun; Seredkina, Natalya; Moroni, Gabriella; Eilertsen, Gro Østli; Holdaas, Hallvard; Strøm, Erik Heyerdahl; Bakland, Gunnstein; Meroni, Pier Luigi; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)
      Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human ...

    • Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis 

      Dorraji, Seyed Esmaeil; Hovd, Aud-Malin Karlsson; Kanapathippillai, Premasany; Bakland, Gunnstein; Eilertsen, Gro Østli; Figenschau, Stine; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)
      Tertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Here we investigated the presence of mesenchymal stem cells (MSCs) in the development of TLS in murine LN, as well as the role of human MSCs as lymphoid tissue organizer (LTo) cells on the activation of CD4+ T cells from three groups of donors ...