Browsing Artikler, rapporter og annet (medisinsk biologi) by Author "Næsheim, Torvind"

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    • The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-12)
      <p><i>Introduction - </i>Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary hypertension. Its effect on cardiometabolic efficiency is unknown. A potential cardiac energy sparing effect of this drug could imply a positive prognostic effect, particularly in patients with right heart failure from pulmonary hypertension. <p><i>Method - </i>We infused Riociguat ...

    • Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)
      Cardiovascular diseases are often characterized by dysfunctional endothelium. To compensate for the related lack of nitric oxide (NO), a class of soluble guanylate cyclase (sGC) stimulators and activators have been developed with the purpose of acting downstream of NO in the NO-sGC-cGMP cascade. These drugs have been discovered using photoaffinity labeling of sGC and high-throughput screening of a ...

    • Offshore telementored ultrasound: a quality assessment study 

      Vatsvåg, Victoria; Todnem, Kjetil; Næsheim, Torvind; Cathcart, John; Kerr, Daniel; Oveland, Nils Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)
      <p><i>Background - </i>Telementored ultrasound (US) connects experts to novices through various types of communication and network technologies with the overall aim to bridge the medical imaging gap between patients’ diagnostic needs and on-site user experience. The recurrent theme in previous research on remote telementored US is the limited access to US machines and experienced users. This study ...