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norskBrowsing Artikler, rapporter og annet (medisinsk biologi) by Author "Sørbye, Sveinung Wergeland"
Now showing items 1-20 of 28
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Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor receptor-3 (VEGFR-3), are strongly involved in angiogenesis. This study ... -
High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator
(Journal article; Tidsskriftartikkel, 2012)The immune status is important in cancer patients. Tissue microarrays from 249 patients with soft tissue sarcomas were constructed. Immunohistochemistry was used to evaluate the CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in tumors. High density of CD20+ lymphocytes is an independent positive prognostic indicator for these patients. -
HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage ... -
HPV mRNA is more specific than HPV DNA in triage of women with minor cervical lesions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18)311 women were scheduled for triage of minor cervical lesions (ASC-US / LSIL). 30 women (9.6%) had ASC-H/HSIL cytology at triage and 281 women (90.4%) had ASC-US/LSIL or normal cytology. The HPV DNA test was positive in 92 (32.7%) of 281 instances, and 37 (13.2%) were mRNA positive. Of the 132 women with repeated ASC-US/LSIL, we received biopsies from 97.0% (65/67) of the DNA-positive and 92.9% ... -
HPV mRNA test in primry screening of women 20-34 years
(Conference object; Konferansebidrag, 2011) -
HPV mRNA test in women with minor cervical lesions : experience of the University Hospital of North Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)In the Norwegian Cervical Cancer Screening Programme tests for detection of human papillomavirus (HPV) are used to triage women with minor cytological cervical lesions. The material in this study comprises samples from 1798 women in the period 2006–2008. The HPV test was performed according to the guidelines of the Norwegian Cancer Registry. The HPV mRNA test (PreTect HPV-Proofer) detects and types ... -
HPV mRNA testing in triage of women with ASC-US cytology may reduce the time for CIN2+ diagnosis compared with repeat cytology.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: In delayed HPV triage women with atypical squamous cells of uncertain significance (ASC-US) cytology are retested after 6-12 months in order to decide whether they should be referred for colposcopy, further follow-up cytology or routine screening in three years. Triage using a specific HPV E6/E7 mRNA test may reduce referrals for colposcopy of women with ASC-US cytology compared to HPV ... -
HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions
(Conference object; Konferansebidrag, 2013)In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ... -
Ny generasjon HPV-tester på vent
(Chronicle; Kronikk, 2010-09-18)Ny forskning viser at gentester for humant papillomvirus (HPV) siler ut de behandlingstrengende i langt større grad enn celleprøver. Samtidig er det grunn til å tro at mRNA-tester bør velges fremfor DNA-tester. -
Patolog slår tilbake mot gynekologer
(Chronicle; Kronikk, 2011-12-12)Antallet tilfeller av livmorhalskreft er stabilt i Norge, men har gått ned ved de fem sykehusene som har brukt den RNA-baserte HPV-testen, hevder patolog Sveinung Wergeland Sørbye. -
Primary cervical cancer screening with an HPV mRNA test: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-11)<b>Objectives</b> To assess the performance of a 5-type human papillomavirus (HPV) messenger RNA (mRNA) test in primary screening within the framework of the Norwegian population-based screening programme. <br> <b>Design</b> Nationwide register-based cohort study. <br> <b>Setting</b> In 2003–2004, general practitioners and gynaecologists recruited 18 852 women for participation in a primary ... -
Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of cancer. In soft tissue sarcomas, the expression profiles of the PI3K/Akt pathway components are poorly defined and their significance uncertain. We aimed to investigate the prognostic impact of ... -
Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune system in soft tissue sarcomas (STS). The significance of macrophages (CD68), their growth factor macrophage colony-stimulating factor (M-CSF), its ... -
Prognostic Impact of Jab1, p16, p21, p62, Ki67 and Skp2 in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Purpose The purpose of this study is to clarify the prognostic significance of expression of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas (STS). Optimised treatment of STS requires better identification of high risk patients who will benefit from adjuvant therapy. The prognostic significance of Jab1, p16, p21, p62, Ki67 and Skp2 in STS has not been sufficiently investigated. ... -
Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting ... -
Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: The purpose of this study was to clarify the prognostic significance of peritumoral lymphocyte infiltration in the capsule of soft tissue sarcomas (STS). Multiple observations in preclinical and clinical studies have shown that the immune system has a role in controlling tumor growth and progression. Prognostic markers in potentially curable STS should guide therapy after surgical ... -
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant ... -
The Prognostic Impact of TGF-beta 1, Fascin, NF-kappa B and PKC-zeta Expression in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Transforming growth factor-β (TGF-β), fascin, nuclear factor-kappa B (NF-κB) p105, protein-kinase C-zeta (PKC-ζ), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms involved in cell dedifferentiation. In soft tissue sarcomas, their expression profile is poorly defined and their significance is uncertain. We aimed to investigate the ... -
Prognostic value of the MicroRNA regulators dicer and drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-11)Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. We have investigated the prognostic impact of Dicer and Drosha and their correlation with miR-126 expression in a large cohort of non-small cell lung cancer (NSCLC) patients. We aimed to find ...
