• Agnoprotein of polyomavirus BK interacts With proliferating cell nuclear antigen and inhibits DNA replication 

      Gerits, Nancy; Johannessen, Mona; Tümmler, Conny; Walquist, Mari; Kostenko, Sergiy; Snapkov, Igor; van Loon, Barbara; Ferrari, Elena; Hübscher, Ulrich; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-01)
      Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel cellular interaction partners. <p>Methods: Yeast-two hybrid assay was performed ...
    • BKV Agnoprotein Interacts with alpha-Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein, and Negatively Influences Transport of VSVG-EGFP 

      Johannessen, Mona; Walquist, Mari; Gerits, Nancy; Dragset, Marte Singsås; Spang, Anne; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagation. Studies with ...
    • Differentially Expressed MicroRNAs in Meningiomas Grades I and II Suggest Shared Biomarkers with Malignant Tumors 

      El-Gewely, Mohamed Raafat; Andreassen, Morten; Walquist, Mari; Ursvik, Anita; Knutsen, Erik; Nystad, Mona; Coucheron, Dag H; Myrmel, Kristin Smistad; Hennig, Rune; Johansen, Steinar D (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-03)
      Meningiomas represent the most common primary tumors of the central nervous system, but few microRNA (miRNA) profiling studies have been reported so far. Deep sequencing of small RNA libraries generated from two human meningioma biopsies WHO grades I (benign) and II (atypical) were compared to excess dura controls. Nineteen differentially expressed miRNAs were validated by RT-qPCR using tumor RNA ...