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norskArtikler, rapporter og annet (medisinsk biologi): Recent submissions
Now showing items 841-860 of 1105
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Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Marine mammal Brucella spp. have been isolated from pinnipeds (B. pinnipedialis) and cetaceans (B. ceti) from around the world. Although the zoonotic potential of marine mammal brucellae is largely unknown, reports of human disease exist. There are few studies of the mechanisms of bacterial intracellular invasion and multiplication involving the marine mammal Brucella spp. We examined the infective ... -
En pionerforsker
(Journal article; Tidsskriftartikkel, 2013)Professor Svein Dahl ved Universitetet i Tromsø var en framtredende og nyskapende legemiddelforsker. De metodene han benyttet, brukes den dag i dag av farmasøytisk industri og forskere over hele verden. -
Drug design på data'n
(Journal article; Tidsskriftartikkel, 2013)Hva skjer i hjernen når vi føler oss glade og optimistiske? Hvorfor virker penicillin mot bakterieinfeksjoner, mens paracet virker mot hodepine? Og hvordan i all verden kan antidepressiva påvirke humøret og dermed virke mot depresjon? Svaret er molekyler. -
Vet brukerne hva de gjør?
(Chronicle; Kronikk, 2013-02-06)Nordmenns bruk av alternativ behandling er stadig under debatt blant leger, alternative behandlere og forskere, senest i forbindelse med NRK-programmet Folkeopplysningen. Det heteste temaet er om det finnes holdbar vitenskapelig dokumentasjon for at alternative behandlingsformer virker. Mange ser et paradoks i at alternativ behandling til tross for mangelfull dokumentasjon omsettes for milliardbeløp ... -
Vitamin D - a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The present literature review is part of the NNR5 project with the aim of reviewing and updating the scientific basis of the 4th edition of the Nordic Nutrition Recommendations (NNR) issued in 2004. Objectives: The overall aim was to review recent scientific data on the requirements and health effects of vitamin D and to report it to the NNR5 Working Group, who is responsible for updating ... -
Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)High blood concentrations of n-6 fatty acids (FAs) relative to n-3 FAs may lead to a “physiological switch” towards permanent low-grade inflammation, potentially influencing the onset of cardiovascular and inflammatory diseases, as well as cancer. To explore the potential effects of FA ratios prior to disease onset, we measured blood gene expression profiles and plasma FA ratios (linoleic ... -
Behovsmedisinering i sykehjem: Forskrivning, bruk og dokumentasjon av effekt.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Bakgrunn: For å sikre sykehjems-pasienter effektiv og forsvarlig legemiddelbehandling, kreves hensiktsmessige rutiner for forskrivning, håndtering og effektdokumentasjon både av legemidler gitt fast og ved behov. Vår kunnskap om forholdene rundt behovsmedisinering er begrenset. Hensikt: Få kunnskap om behovsmedisinering ved å kartlegge forskrivning og utlevering av behovslegemidler ved ett utvalgt ... -
Overdiagnosis of breast cancer in the Norwegian Breast Cancer Screening Program estimated by the Norwegian Women and Cancer cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifetime outside screening. This analysis compares the cumulative incidence of breast cancer in screened and unscreened women in Norway from the start of the fully implemented Norwegian ... -
Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-20)Background: Salmon trypsin is shown to increase secretion of the pro-inflammatory cytokine interleukin (IL)-8 from human airway epithelial cells through activation of PAR-2. Secretion of IL-8 induced by king crab trypsin is observed in a different concentration range compared to salmon trypsin, and seems to be only partially related to PAR-2 activation. This report aim to identify differences in ... -
Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were ... -
Level of selected toxic elements in meat, liver, tallow and bone marrow of young semi-domesticated reindeer (Rangifer tarandus tarandus L.) from Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objectives. To gain knowledge on toxic elements in semi-domesticated reindeer and their distribution in meat, liver, tallow and bone marrow. The correlations between concentrations in meat and liver, as well as the use of the latter as an indicator for toxic elements in meat, were also investigated. Study design. Cross-sectional study on population of semi-domesticated reindeer from 2 northern ... -
Persistent organic pollutants in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The aim of this project was to study 14 polychlorinated biphenyls (PCBs), 5 dichlorodiphenyl trichloroethans (DDTs), 12 organochlorine pesticides (OCPs) and 6 polybrominated diphenylethers (PBDEs) in meat, liver, tallow and bone marrow from semi-domesticated reindeer. Methods: Meat, liver, tallow, and bone marrow samples (n= 30) were collected from semi-domesticated reindeer in Northern ... -
Level of selected nutrients in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer t. tarandus L.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objectives: To acquire new knowledge on the nutritional composition of semi-domesticated reindeer (Rangifer t. tarandus L.) and their nutritional value for humans. The results could be useful in updating the Norwegian Food Composition Database, whose current data on reindeer is limited. Study design: Cross-sectional study on population of semi-domesticated reindeer from 2 northern Norwegian counties ... -
Motivation to persist with internet-based cognitive behavioural treatment using blended care: a qualitative study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)The prevalence of depression is high and results in huge costs for society. Internet-based cognitive behavioural treatment (ICBT) has been suggested for use in primary care and has been shown to be more effective when combined with human support. However, non-completion rates remain a challenge. Current recommendations state that steps to improve persistence with ICBT should be determined and the ... -
High referral rates to secondary care by general practitioners in Norway are associated with GPs' gender and specialist qualifications in family medicine, a study of 4350 consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Referral rates of general practitioners (GPs) are an important determinant of secondary care utilization. The variation in these rates across GPs is considerable, and cannot be explained by patient morbidity alone. The main objective of this study was to assess the GPs’ referral rate to secondary care in Norway, any associations between the referral decision and patient, GP, health care characteristics ... -
Ethnic difference in the prevalence of angina pectoris in Sami and non-Sami populations: the SAMINOR study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Objective: To assess the population burden of angina pectoris symptoms (APS), self-reported angina and a combination of these, and explore potential ethnic disparity in their patterns. If differences in APS were found between Sami and non-Sami populations, we aimed at evaluating the role of established cardiovascular risk factors as mediating factors. Design: Cross-sectional population-based ... -
HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions
(Conference object; Konferansebidrag, 2013)In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ... -
Hepatitis B and C viruses and survival from hepatocellular carcinoma in the Arkhangelsk region: a Russian registry-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Introduction. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The prevalence of hepatitis B (HBV) and C (HCV) in Russia was 7.6 and 5.4 per 100,000, respectively. The aim of this study was to assess the proportion of HCV and HBV infection among HCC patients, to evaluate associations between HCV, HBV and stage of HCC and to compare survival of HCC patients by their HBV/HCV ... -
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ... -
Doctors are to blame for perceived medical adverse events. A cross sectional population study. The Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Most current knowledge of the incidence of medical adverse events (AEs) comes from studies carried out in hospital settings. Little is known about AEs occurring outside hospitals, in spite the fact that most of contacts between patients and health care take place in primary care. Small sample population studies report that 4–49% of the general public have experienced AEs related to their own or ...
