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dc.contributor.authorSvistounov, Dmitri
dc.contributor.authorOteiza, Ana
dc.contributor.authorZykova, Svetlana
dc.contributor.authorSørensen, Karen Kristine
dc.contributor.authorMcCourt, Peter Anthony
dc.contributor.authorMcLachlan, Andrew J
dc.contributor.authorMccuskey, Robert Scott
dc.contributor.authorSmedsrød, Bård
dc.date.accessioned2014-03-20T13:25:08Z
dc.date.available2014-03-20T13:25:08Z
dc.date.issued2013
dc.description.abstractAging is characterized by progressive loss of metabolic and biochemical functions and accumulation of metabolic by-products, including advanced glycation end products (AGEs), which are observed in several pathological conditions. A number of waste macromolecules, including AGEs are taken up from the circulation by endocytosis mainly into liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs). However, AGEs still accumulate in different tissues with aging, despite the presence of this clearance mechanism. The aim of the present study was to determine whether the efficiency of LSECs and KCs for disposal of AGEs changes through aging.en
dc.identifier.citationExperimental Gerontology 48(2013) nr. 6 s. 549-556en
dc.identifier.cristinIDFRIDAID 1030101
dc.identifier.doihttp://dx.doi.org/10.1016/j.exger.2013.03.005
dc.identifier.issn0531-5565
dc.identifier.urihttps://hdl.handle.net/10037/5993
dc.identifier.urnURN:NBN:no-uit_munin_5686
dc.language.isoengen
dc.publisherElsevieren
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Otolaryngology: 755en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Otorhinolaryngologi: 755en
dc.titleHepatic disposal of advanced glycation end products during maturation and agingen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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