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dc.contributor.authorZhou, Humin
dc.contributor.authorMa, Hongye
dc.contributor.authorWei, Wei
dc.contributor.authorJi, Donghua
dc.contributor.authorSong, Xiaobo
dc.contributor.authorSun, Jinglu
dc.contributor.authorZhang, Jianing
dc.contributor.authorJia, Li
dc.date.accessioned2014-03-21T09:01:06Z
dc.date.available2014-03-21T09:01:06Z
dc.date.issued2013
dc.description.abstractb-1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II membrane-bound glycoproteins. These enzymes catalyze the biosynthesis of different glycoconjugates and saccharide structures, and have been recognized to be involved in various diseases. In this study, we sought to determine the expressional profiles of B4GALT family in four pairs of parental and chemoresistant human leukemia cell lines and in bone marrow mononuclear cells (BMMC) of leukemia patients with multidrug resistance (MDR). The results revealed that B4GALT1 and B4GALT5 were highly expressed in four MDR cells and patients, altered levels of B4GALT1 and B4GALT5 were responsible for changed drug-resistant phenotype of HL60 and HL60/adriamycin-resistant cells. Further data showed that manipulation of these two gene expression led to increased or decreased activity of hedgehog (Hh) signaling and proportionally mutative expression of p-glycoprotein (P-gp) and MDR-associated protein 1 (MRP1) that are both known to be related to MDR. Thus, we propose that B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of MDR of human leukemia cells, probably by regulating the activity of Hh signaling and the expression of P-gp and MRP1.en
dc.identifier.citationCell Death and Disease (2013), vol. 4: e654en
dc.identifier.cristinIDFRIDAID 1046006
dc.identifier.doihttp://dx.doi.org/10.1038/cddis.2013.186
dc.identifier.issn2041-4889
dc.identifier.urihttps://hdl.handle.net/10037/6054
dc.identifier.urnURN:NBN:no-uit_munin_5728
dc.language.isoengen
dc.publisherMacmillian Publishersen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en
dc.titleB4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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