• Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study 

      Ozolina, Agnese; Sarkele, Marina; Sabelnikovs, Olegs; Skesters, Andrejs; Jaunalksne, Inta; Serova, Jelena; Ievins, Talins; Bjertnæs, Lars J.; Vanags, Indulis (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-28)
      Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to investigate the relationships between ARDS diagnosis and plasma concentrations of tissue factor (TF), tissue plasminogen activator (t-PA), and ...
    • Activity-related pain in patients with chronic musculoskeletal disorders 

      Damsgård, Elin; Thrane, Gyrd; Anke, Audny; Fors, Terese; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Purpose. Activity related pain may be a barrier to rehabilitation in patients with chronic musculoskeletal disorders. This study investigated patients’ reports of increased pain during activity, and the association between such pain and psychological factors and pain variables. Method. Questionnaires from 232 adults with chronic musculoskeletal pain measured pain intensity, spread of pain and ...
    • Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock 

      Orrem, Hilde L.; Nilsson, Per H.; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Ø.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
      Aims: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. <br> <br> Methods and results: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary ...
    • Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ...
    • The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations 

      Stenberg, Thor Allan; Kildal, Anders Benjamin; Sanden, Espen; How, Ole-Jakob; Hagve, Martin; Ytrehus, Kirsti; Larsen, Terje; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance 

      Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
      Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ...
    • Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function 

      Hande, Liv Nesse; Thunhaug, Hilde; Enebakk, Terje; Ludviksen, Judith K; Pettersen, Kristin; Hovland, Anders; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)
      <i>Background</i> - Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results. The effect of n-3 PUFA in patients with familial hypercholesterolemia (FH), a group with particularly high risk of cardiovascular disease, is not well established.<p><p> <i>Objective</i> ...
    • Adherence and factors affecting satisfaction in long-term telerehabilitation for patients with chronic obstructive pulmonary disease: a mixed methods study 

      Hoaas, Hanne; Andreassen, Hege K; Lien, Linda Aarøen; Hjalmarsen, Audhild; Zanaboni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-25)
      <i>Background</i>: Telemedicine may increase accessibility to pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD), thus enhancing long-term exercise maintenance. We aimed to explore COPD patients’ adherence and experiences in long-term telerehabilitation to understand factors affecting satisfaction and potential for service improvements.<p> <p><i>Methods</i>: A two-year pilot ...
    • Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus 

      Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ...
    • Adjacent Disc Degeneration After Lumbar Total Disc Replacement or Non-operative Treatment: A Randomized Study With Eight-year Follow-up 

      Furunes, Håvard; Hellum, Christian; Espeland, Ansgar; Brox, Jens Ivar; Småstuen, Milada C; Berg, Linda; Storheim, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-15)
      <p><i>Study Design</i>: A randomized controlled multicenter trial with 8-year follow-up.</p> <p><i>Objective</i>: The aim of this study was to assess the long-term development of adjacent disc degeneration (ADD) after lumbar total disc replacement (TDR) or nonoperative treatment, and to analyze the association between ADD development and clinical outcome.</p> <p><i>Summary of Background ...
    • Adolescent self-harm and suicidal behavior and young adult outcomes in indigenous and non-indigenous people 

      Eckhoff, Christian; Sørvold, Maria Therene; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-18)
      The aim of this study was to examine the associations between self-harm and suicidal behavior in indigenous Sami and non-Sami adolescents and mental health and social outcomes in young adulthood. Data were obtained by linking the Norwegian Patient Registry (2008–2012), the National Insurance Registry (2003–2013), and the Norwegian Arctic Adolescent Health Study, a school-based survey inviting all ...
    • Adoption of routine telemedicine in Norway: The current picture 

      Zanaboni, Paolo; Knarvik, Undine; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Adoption of telemedicine : from pilot stage to routine delivery 

      Zanaboni, Paolo; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Today there is much debate about why telemedicine has stalled. Teleradiology is the only widespread telemedicine application. Other telemedicine applications appear to be promising candidates for widespread use, but they remain in the early adoption stage. The objective of this debate paper is to achieve a better understanding of the adoption of telemedicine, to assist those trying to move applications ...
    • Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis 

      Hudson, Jemma; Cruickshank, Moira; Quinton, Richard; Aucott, Lorna; Aceves-Martins, Magaly; Gillies, Katie; Bhasin, Shalender; Snyder, Peter J; Ellenberg, Susan S; Grossmann, Mathis; Travison, Thomas G; Gianatti, Emily J; van der Schouw, Yvonne T; Emmelot-Vonk, Marielle H; Giltay, Erik J; Hackett, Geoff; Ramachandran, Sudarshan; Svartberg, Johan; Hildreth, Kerry L; Groti Antonic, Kristina; Brock, Gerald B; Tenover, J Lisa; Tan, Hui Meng; Kong, Christopher Ho Chee; Tan, Wei Shen; Marks, Leonard S; Ross, Richard J; Schwartz, Robert S; Manson, Paul; Roberts, Stephen; Andersen, Marianne; Magnussen, Line Velling; Hernández, Rodolfo; Oliver, Nick; Wu, Frederick; Dhillo, Waljit S; Bhattacharya, Siladitya; Brazzelli, Miriam; Jayasena, Channa N (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)
      Background Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of testosterone trials available, to analyse subtypes of all cardiovascular events observed during treatment, and to investigate the effect of incorporating data ...
    • Adverse events in hospitalised cancer patients: a comparison to a general hospital population 

      Haukland, Ellinor Christin; von Plessen, Christian; Nieder, Carsten; Vonen, Barthold (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
      <p><i>Background</i>: Patients with cancer are often treated by many healthcare providers, receive complex and potentially toxic treatments that can increase the risk for iatrogenic harm. The aim of this study is to investigate whether hospitalised cancer patients are at higher risk of adverse events (AEs) compared to a general hospital population.</p> <p><i>Material and methods</i>: A total of ...
    • Adverse events reporting by obstetric units in Norway as part of their quality assurance and patient safety work: an analysis of practice 

      Johansen, Lars Thomas; Braut, Geir Sverre; Acharya, Ganesh; Andresen, Jan Fredrik; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Background - The Norwegian Board of Health Supervision aims to contribute to the improvement of quality and patient safety in the healthcare services. Planned audits were performed to investigate how 12 selected Norwegian obstetric units reported and analyzed adverse events as the part of their quality assurance and patient safety work.<p> Methods - Serious adverse events coded as birth asphyxia, ...
    • Against All Odds? Sami Women’s Lower NEET Experience in An Arctic Context: Education and Work Participation among Multicultural Young People in Northern-Norway, the Norwegian Arctic Adolescent Health Study (NAAHS) 

      Bania, Elisabeth Valmyr; Eckhoff, Christian; Ekornes, Stine M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
      The present paper explores Sami women’s lower NEET (Not engaged in Education, Employment or Training) experience in an ethnoreligious multicontext perspective. Data are derived from a cross-sectional cohort and registry follow-up study in Northern Norway, 2003–2012, and data from Statistics Norway are included for an up-to date data analysis (2021). This is a cross-sectional cohort and registry data ...
    • Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population 

      Gaya de Costa, Mariana; Poppelaars, Felix; van Kooten, Cees; Mollnes, Tom Eirik; Tedesco, Francesco; Würzner, Reinhard; Trouw, Leendert A.; Truedsson, Lennart; Daha, Mohamed R.; Roos, Anja; Seelen, Marc A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-20)
      <p><i>Introduction</i>: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement ...
    • Agreement between anatomical M-mode and tissue Doppler imaging in the assessment of fetal atrioventricular annular plane displacement in uncomplicated pregnancies: A prospective longitudinal study 

      Zanardini, Cristina; D'Antonio, Francesco; Hvingel, Bodil; Vårtun, Åse; Prefumo, Federico; Flacco, Maria E.; Manzoli, Lamberto; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)
      Aim To evaluate the level of agreement between M‐mode and pulsed‐wave tissue Doppler imaging (PW‐TDI) techniques in assessing fetal mitral annular plane systolic excursion (MAPSE), tricuspid annular plane systolic excursion (TAPSE) and septal annular plane systolic excursion (SAPSE) in a low‐risk population. Methods This prospective longitudinal study included healthy fetuses assessed from 18 to ...
    • Agreement between preload reserve measured by impedance cardiography and echocardiography during pregnancy 

      Liang, Huan; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-05)
      <i>Purpose</i>: Accurate assessment of cardiac function is important during pregnancy. Echocardiography and impedance cardiography (ICG) are commonly used noninvasive methods to measure stroke volume (SV) and cardiac output (CO). The diference in stroke volume (ΔSV) or cardiac output (ΔCO) measured at baseline and after passive leg raising (PLR) is a measure of preload reserve that predicts volume ...