Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury 

      Mikolic, Ana; van Klaveren, David; Oude Groeniger, Joost; Wiegers, E; Lingsma, Hester F; Zeldovich, Marina; von Steinbüchel, Nicole; Maas, Andrew I.R.; Roeters van Lennep, Jeanine; Polinder, Suzanne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-19)
      Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative ...

    • Differences in gene expression between first and third trimester human placenta : a microarray study. 

      Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The human placenta is a rapidly developing organ that undergoes structural and functional changes throughout the pregnancy. Our objectives were to investigate the differences in global gene expression profile, the expression of imprinted genes and the effect of smoking in first and third trimester normal human placentas. Placental samples were collected from 21 women with uncomplicated pregnancies ...

    • Differences in implementation of family focused practice in hospitals: a cross-sectional study 

      Skogøy, Bjørg Eva; Maybery, Daryl; Ruud, Torleif; Sørgaard, Knut W.; Peck, Gro Christensen; Kufås, Elin; Stavnes, Kristin Anne; Thorsen, Eivind; Ogden, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-10)
      <p><i>Background</i>: Changes in Norwegian law and health policy require all health professionals to help safeguard the provision of information and follow-up for the children of parents with mental or physical illness, or substance abuse problems, to decrease their risk of psychosocial problems. There is a lack of knowledge on how the national changes have been received by hospital-based health ...

    • Differences in time-critical interventions and radiological examinations between adult and older trauma patients: A national register-based study 

      Cuevas-Østrem, Mathias; Wisborg, Torben; Røise, Olav; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      BACKGROUND<p> <p>Older trauma patients are reported to receive lower levels of care than younger adults. Differences in clinical management between adult and older trauma patients hold important information about potential trauma system improvement targets. The aim of this study was to compare prehospital and early in-hospital management of adult and older trauma patients, focusing on time-critical ...

    • Differential profile of protumor immunological factors between the tumor site and the tumor-free site – predictive potential of IL-8 and COX2 for colorectal cancer and metastasis 

      Cui, Guanglin; Yuan, Aping; Pang, Zhigang; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-05)
      To study the role of host immune surveillance in the initiation and progression of colorectal cancer (CRC), a set of protumor immunological factors was determined by quantitative real-time PCR (q-PCR) between the primary tumor and the adjacent tumor-free site tissues in 63 patients with colorectal neoplasms. Results showed that expression levels of interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-23, and ...

    • Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Vik, Jørg; de Petris, Luigi; Dønnem, Tom; Strell, Carina; Østman, Arne; Busund, Lill-Tove; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)
      Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) ...

    • Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer? 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
      The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...

    • Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts 

      Bahar, Ramez; Dahl-Eriksen, Øystein; Busund, Rolf; Dahl, Per Erling; Hermansen, Stig Eggen; Iqbal, Amjid; Mannsverk, Jan; Myrmel, Truls; Steigen, Terje; Trovik, Thor; Sørlie, Dag Glen; Bartnes, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      Objectives: The benefits of coronary artery bypass surgery depend on lasting graft patency. To aid rational graft selection, the relative long-term merits of radial artery and saphenous vein grafts need to be determined by a gold standard method and with minimal clinically driven selection bias. Methods: The patency rates of various conduits were determined by direct angiography in 76 patients from ...

    • Discovering the structure and organization of a free Cantonese emotion-label word association graph to understand mental lexicons of emotions 

      Wong, Ting Yat; Fang, Zhiqian; Yu, Yat To; Cheung, Charlton; Hui, Christy L. M.; Elvevåg, Brita; De Deyne, Simon; Sham, Pak Chung; Chen, Eric Y. H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-15)
      Emotions are not necessarily universal across different languages and cultures. Mental lexicons of emotions depend strongly on contextual factors, such as language and culture. The Chinese language has unique linguistic properties that are different from other languages. As a main variant of Chinese, Cantonese has some emotional expressions that are only used by Cantonese speakers. Previous work on ...

    • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

      Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
      <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...

    • Disease-specific outcomes of Radical Prostatectomies in Northern Norway; A case for the impact of perineural infiltration and postoperative PSA-doubling time 

      Andersen, Sigve; Richardsen, Elin; Nordby, Yngve; Ness, Nora; Størkersen, Øystein; Al-Shibli, Khalid; Dønnem, Tom; Bertilsson, Helena; Busund, Lill-Tove; Angelsen, Anders; Bremnes, Roy M. (Tidsskriftartikkel; Journal article; Peer reviewed, 2014)
      Background Prostate cancer is the most common male malignancy and a mayor cause of mortality in the western world. The impact of clinicopathological variables on disease related outcomes have mainly been reported from a few large US series, most of them not reporting on perineural infiltration. We therefore wanted to investigate relevant cancer outcomes in patients undergoing radical prostatectomy ...

    • Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies 

      Solmi, Marco; Fiedorowicz, Jess; Poddighe, Laura; Delogu, Marco; Høye, Anne; Miola, Alessandro; Heiberg, Ina Heidi; Stubbs, Brendon; Smith, Lee; Larsson, Henrik; Attar, Rubina; Nielsen, René E; Cortese, Samuele; Shin, Jae Il; Firth, Joseph; Fusar-Poli, Paolo; Yatham, Lakshmi N; Carvalho, Andre F; Castle, David J; Correll, Christoph U; Seeman, Mary V (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      <p><i>Objective:</i> This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. <p><i>Methods:</i> The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and ...

    • Dispatch guideline adherence and response interval-a study of emergency medical calls in Norway 

      Ellensen, Eirin Nybø; Wisborg, Torben; Hunskaar, Steinar; Zakariassen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-13)
      Background:<br> The Emergency Medical Communication Centre (EMCC) operators in Norway report using the Norwegian Index for Medical Emergency Assistance (Index), a criteria-based dispatch guideline, in about 75 % of medical emergency calls. The main purpose of a dispatch guideline is to assist the operator in securing a correct response as quickly as possible. The effect of using the guideline on ...

    • Dissection of the internal carotid artery and stroke after mandibular fractures: a case report and review of the literature 

      Tveita, Ingrid Aune; Madsen, Martin Ragnar Skjerve; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-02)
      Background: We present a report of a patient with blunt trauma and mandibular fractures who developed a significant cerebral infarction due to an initially unrecognized injury of her left internal carotid artery. We believe that increased knowledge of this association will facilitate early recognition and hence prevention of a devastating outcome. <br>Case presentation: A 41-year-old ethnic ...

    • Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study 

      Synnestvedt, Marit; Borgen, Elin; Wist, Erik; Wiedswang, Gro; Weyde, Kjetil; Risberg, Terje; Kersten, Christian; Mjaaland, Ingvil; Vindi, Lise; Schirmer, Cecilie; Nesland, Jahn M; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-12-22)
      Background: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identify adjuvant insufficiently treated patients to be offered secondary adjuvant treatment intervention, and as a surrogate marker for therapy response.<p> <p>Methods: A total of ...

    • The distribution of hand fractures at the university hospital of north Norway 

      Weum, Sven; Millerjord, Siri; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-06)
      BACKGROUND: The objective of this study was to describe the fracture pattern for hand fractures in the Arctic region of Norway. MATERIALS AND METHODS: Using the hospital's radiological information system and picture archiving and communication system all traumatic hand fractures in the year of 2010 were registered. Fractures in the carpal, metacarpal, and phalangeal bones were included in the ...

    • District nursing between the local and the international. Northern Norway 1890-1940. 

      Elstad, Ingunn (Working paper; Arbeidsnotat, 2006)
      The article explores the history of voluntary district nursing in Northern Norway 1880- 1940. A popular movement of women’s associations met the tuberculosis epidemic, which peaked late in the North. District nursing was developed partly from the European movement of Christian relief and sick care, partly from local traditions of neighbourly assistance. Local girls were trained and employed by local ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-10)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative repair mechanisms regulated by the transcription factor ...

    • Diverting stomas reduce reoperation rates for anastomotic leak but not overall reoperation rates within 30 days after anterior rectal resection: a national cohort study 

      Myrseth, Elisabeth; Nymo, Linn Såve; Gjessing, Petter Fosse; Norderval, Stig (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)
      Purpose A diverting stoma is commonly formed to reduce the rate of anastomotic leak following anterior resection with anastomosis, although some studies question this strategy. The aim of this study was to assess the leak rates and overall complication burden after anterior resection with and without a diverting stoma.<p> <p>Methods A 5-year national cohort with prospectively registered data of ...

    • DNA Damage Response 

      Oksenych, Valentyn; Kainov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)