Viser treff 881-900 av 1974

    • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma 

      Haider, Zahra; Landfors, Mattias; Golovleva, Irina; Erlanson, Martin; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Norén-Nyström, Ulrika; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)
      Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ...
    • Assessing communication during remote follow-up of users with pacemakers in Norway: The Nordland study, a randomized trial 

      Catalán-Matamoros, Daniel; Lopez-Villegas, Antonio; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-21)
      As effective communication is a key ingredient for the provision of quality healthcare services, this study aimed to explore the communication experiences in the remote monitoring of older adults with a pacemaker. The study was based on a non-masked randomized observational design. The Healthcare Communication Questionnaire and in-depth interviews were conducted for data collection. A total of 49 ...
    • Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation 

      Håheim, Brage; Kondratyev, Timofey; Dietrichs, Erik Sveberg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)
      Rewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside ...
    • Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial 

      Ferrand, Rashida A.; McHugh, Grace; Rehman, Andrea M.; Mujuru, Hilda A.; Simms, Victoria; Majonga, Edith D.; Nicol, Mark P.; Flægstad, Trond; Gutteberg, Tore Jarl; Gonzalez-Martinez, carmen; Corbett, Elizabeth L.; Rowland-Jones, Sarah; Kranzer, Katharina; Weiss, Helen Anne; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)
      <i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ...
    • Management of patients with acute ST-segment elevation myocardial infarction in Russian hospitals adheres to international guidelines 

      Kontsevaya, Anna; Bates, Katie; Schirmer, Henrik; Bobrova, Natalia; Leon, David A.; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
      <i>Objective</i> - Russia has one of the highest cardiovascular mortality rates. Modernisation of the Russian health system has been accompanied by a substantial increase in uptake of percutaneous coronary intervention (PCI), which substantially reduces the risk of mortality in patients with acute ST-elevation myocardial infarction (STEMI). This paper aims to describe contemporary Hospital treatment ...
    • Platelet count and risk of major bleeding in venous thromboembolism 

      Johnsen, Håkon Sandbukt; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)
      <p>The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major bleeding. Participants comprised 744 patients with incident VTE derived from the Tromsø Study. Major ...
    • Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020 

      Johansen, Tone Bjordal; Astrup, Elisabeth; Jore, Solveig; Nilssen, Hege; Dahlberg, Bente Barton; Klingenberg, Claus; Berg, AreStuwitz; Greve-Isdahl, Margrethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)
      In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring ...
    • Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial 

      Nygaard, Ane Sigrid; Rydningen, Mona Birgitte; Stedenfeldt, Mona; Wojniusz, Slawomir; Larsen, Marthe; Lindsetmo, Rolv-Ole; Haugstad, Gro Killi; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-09)
      <p><i>Introduction - </i>Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain. <p><i>Material and ...
    • Vitamin D supplementation for prevention of type 2 diabetes mellitus: To D or Not to D? 

      Pittas, Anastassios G.; Jorde, Rolf; Kawahara, Tetsuya; Dawson-Hughes, Bess (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-26)
      <i>Context</i> - Over the last decade, vitamin D has emerged as a risk determinant for type 2 diabetes and vitamin D supplementation has been hypothesized as a potential intervention to lower diabetes risk. Recently, several trials have reported on the effect of vitamin D supplementation on diabetes prevention in people with prediabetes.<p> <p><i>Evidence Acquisition</i> - A comprehensive literature ...
    • Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer? 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
      The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...
    • Surgery for herniated lumbar disc in private vs public hospitals: A pragmatic comparative effectiveness study 

      Madsbu, Mattis Aleksander; Salvesen, Øyvind; Carlsen, Sven Magnus; Westin, Steinar; Onarheim, Kristian; Nygaard, Øystein Petter; Solberg, Tore; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-04)
      <p><i>Background - </i>There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. <p><i>Methods - </i>Data were obtained from the Norwegian registry for spine surgery. Primary outcome was change in Oswestry disability index (ODI) 1 year after surgery. ...
    • Surgery for Extraforaminal Lumbar Disc Herniation: A Single Center Comparative Observational Study 

      Polak, Samuel B.; Madsbu, Mattis Aleksander; Vangen-Lønne, Vetle; Salvesen, Øyvind; Nygaard, Øystein Petter; Solberg, Tore; Vleggeert-Lankamp, Carmen L. A. M.; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-13)
      <p><i>Background - </i>Surgery on extraforaminal lumbar disc herniation (ELDH) is a commonly performed procedure. Operating on this type of herniation is known to come with more difficulties than on the frequently seen paramedian lumbar disc herniation (PLDH). However, no comparative data are available on the effectiveness and safety of this operation. We sought out to compare clinical outcomes at ...
    • Group mentorship for undergraduate medical students—a systematic review 

      Skjevik, Elise; Boudreau, J. Donald; Ringberg, Unni; Schei, Edvin; Stenfors, Terese; Kvernenes, Monika; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-20)
      <p><i>Introduction - </i>Mentoring has become a prevalent educational strategy in medical education, with various aims. Published reviews of mentoring report very little on group-based mentorship programs. The aim of this systematic review was to identify group-based mentorship programs for undergraduate medical students and describe their aims, structures, contents and program evaluations. Based ...
    • High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition 

      Butola, Ankit; Popova, Daria; Prasad, Dilip K.; Ahmad, Azeem; Habib, Anowarul; Tinguely, Jean-Claude; Basnet, Purusotam; Acharya, Ganesh; Paramasivam, Senthilkumaran; Mehta, Dalip Singh; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)
      Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ...
    • Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models 

      Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)
      Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ...
    • The Master Study in Telemedicine and E-health at the University of Tromsø, Norway, 2005-2018 

      Wynn, Rolf; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
      In this paper we describe the Master Study in Telemedicine and E-health at the University of Tromsø, Norway. The study enrolled its first students in 2005 and was closed in 2018. We describe and discuss the background of the programme, its development and accomplishments and why it was closed. Hopefully, this narrative will be of use to other programmes focusing on e-health.
    • Serum PTH is not a good marker for defining a threshold for vitamin D deficiency 

      Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-01)
      <i>Objective</i>: In addition to its skeletal effects, vitamin D may also be important for health in general. It is uncertain what level of serum 25-hydroxyvitamin D (25(OH)D), marker of vitamin D status, is sufficient for these effects. With decreasing serum 25(OH)D levels there is an increase in serum PTH. The point at which this occurs has been considered as a threshold for vitamin D sufficiency. ...
    • Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV 

      Kumsars, Indulis; Holm, Niels Ramsing; Niemelä, Matti; Erglis, Andrejs; Kervinen, Kari; Kervinen, Evald Høj; Maeng, Michael; Dombrovskis, Andis; Abraitis, Vytautas; Kibarskis, Aleksandras; Trovik, Thor; Latkovskis, Gustavs; Sondore, Dace; Narbute, Inga; Juhl Terkelsen, Christian; Eskola, Markko; Romppanen, Hannu; Laine, Mika; Jensen, Lisette Okkels; Pietila, Mikko; Gunnes, Pål; Hebsgaard, Lasse; Frobert, Ole; Calais, Fredrik; Hartikainen, Juha; Aarøe, Jens; Ravkilde, Jan; Engstrøm, Thomas; Steigen, Terje K.; Thuesen, Leif; Lassen, Jens F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)
      <i>Background</i> - It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.<p> <p><i>Methods</i> ...
    • Behandlingsrater for ryggkirurgi i Norge og Helse Nord 2014-18 

      Ingebrigtsen, Tor; Balteskard, Lise; Guldhaugen, Kristel Ailin; Kloster, Roar; Uleberg, Bård Erling; Grotle, Margreth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
      <i>BAKGRUNN</i> - Formålet med denne studien var å undersøke om behandlingstilbudet innen ryggkirurgi i Helse Nord er i henhold til den vedtatte funksjonsfordelingen mellom sykehusene i regionen, og om det er geografisk variasjon i tilbudet. Vi undersøkte derfor behandlingsrater i Norge og Helse Nord, samt egendekning i Helse Nord, og vurderte aktiviteten i regionen.<p> <p><i>MATERIALE OG METODE</i> ...
    • Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication 

      Nestegard, Oddmund; Johnsen, Kay-Martin; Sørbye, Sveinung; Halvorsen, Fred-Arne; Tønnessen, Tor; Paulssen, Eyvind Jakob; Melby, Kjetil K.; Goll, Rasmus; Florholmen, Jon (Journal article; Tidsskriftartikkel, 2020-09-23)
      <i>Background and aims</i> - Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. pylori treatment resistant cohort compared to the cohorts of newly diagnosed, earlier eradicated and non-infected.<p> <p><i>Material and methods</i> - Patients were selected from routine referrals to the Endoscopy ...