Artikler, rapporter og annet (klinisk medisin): Nye registreringer
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Cannabis use in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, and antidepressants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-27)<i>Objective</i> - Cannabis is an acknowledged risk factor for some mental disorders, but for others the evidence is inconclusive. Prescribed medicinal drugs can be used as proxies for mental disorders. In this study, we investigate how use of cannabis is prospectively related to prescription of antipsychotics, mood stabilizers, antidepressants, and anxiolytics.<p> <p><i>Methods</i> - Data on ... -
Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)<i>Background</i>- It remains uncertain whether activation of the complement system, assessed by the soluble terminal C5b‐9 complement complex (plasma TCC), is associated with future risk of incident venous thromboembolism (VTE).<p> <p><i>Objectives</i>- To investigate the association between plasma levels of TCC and future risk of incident VTE in a nested case‐control study, and to explore ... -
Sexual function in long-term male lymphoma survivors after high-dose therapy with autologous stem-cell transplantation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-19)Reduced sexual function may have negative implications on health related quality of life among lymphoma survivors. A national cross-sectional study among long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplantation auto-SCT treated during 1987–2008 was conducted in 2012–2014. The current study explored sexual functioning among these survivors. Sixty-six percent ... -
Lifestyle behavior among lymphoma survivors after high-dose therapy with autologous hematopoietic stem cell transplantation, assessed by patient-reported outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-30)<i>Introduction</i>: High-dose therapy with autologous stem cell transplantation (HD-ASCT) is associated with an increased risk of late effects. Our aim was to assess lifestyle behavior and factors associated with unhealthy lifestyle among HD-ASCT-treated lymphoma survivors (HD-ASCT-LS).<p><p> <i>Materials and methods</i>: We conducted a national cross-sectional study of HD-ASCT-LS treated during ... -
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous ... -
Comparison of cytokine changes in three different lipoprotein apheresis systems in an ex vivo whole blood model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-29)<i>Introduction</i> - Even if proprotein convertase subtilisin/kexin type 9 inhibitors have replaced lipoprotein apheresis in many patients, lipoprotein apheresis still is an important option in homozygous familial hypercholesterolemia, progressive atherosclerosis or when removal of lipoprotein(a) is indicated. Additional possible favorable effects beyond lipid lowering could include changes in ... -
Long-term outcomes in juvenile idiopathic arthritis: 18 years of follow-up in the population-based Nordic Juvenile Idiopathic Arthritis (JIA) cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)<i>Objectives</i> - This study assessed the long‐term course, remission rate and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population‐based setting from the early biologic era.<p><p> <i>Methods</i> - A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden and Finland ... -
Variation in use of open and laparoscopic distal pancreatectomy and associated outcome metrics in a universal health care system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-01)<i>Background</i> - Universal health care (UHC) should ensure equal access to and use of surgery, but few studies have explored variation in UHC systems. The objective was to describe practice of distal pancreatectomy in Norway covered exclusively by an UHC.<p><p> <i>Methods</i> - Data on all patients undergoing distal pancreatectomy from the Norwegian Patient Register over a 5-year period. ... -
Perioperative infusion of glucagon-like peptide-1 prevents insulin resistance after surgical trauma in female pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-07)Insulin resistance is an independent negative predictor of outcome after elective surgery and increases mortality among surgical patients in intensive care. The incretin hormone glucagon-like peptide-1 (GLP-1) potentiates glucose-induced insulin release from the pancreas but may also increase insulin sensitivity in skeletal muscle and directly suppress hepatic glucose release. Here, we investigated ... -
Family history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-10)<i>Background</i> - The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.<p><p> <i>Methods</i> - This is a prospective cohort study including 1,974,287 males born 1951–2015, of whom 2686 were diagnosed with TC before the age of 30.<p><p> <i>Results</i> - A history of TC in male relatives was significantly ... -
Systematic development of sandwich immunoassays for the plasma secretome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-06)The plasma proteome offers a clinically useful window into human health. Recent advances from highly multiplexed assays now call for appropriate pipelines to validate individual candidates. Here, a workflow is developed to build dual binder sandwich immunoassays (SIA) and for proteins predicted to be secreted into plasma. Utilizing suspension bead arrays, ≈1800 unique antibody pairs are first screened ... -
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)<p><i>Objective - </i>To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). <p><i>Design - </i>Double blind, parallel group, placebo controlled, multicentre trial. <p><i>Setting - </i>Hospital outpatient clinics at six hospitals in Norway. <p><i>Participants ... -
Correlation between baseline GFR and subsequent change in GFR in Norwegian adults without diabetes and in Pima Indians
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)<p><i>Rationale & Objective - </i>An elevated glomerular filtration rate (GFR), or renal hyperfiltration, may predispose individuals to subsequent rapid GFR decline in diabetes, obesity, and metabolic syndrome. Although this hypothesis is supported by results of experimental studies, the importance of hyperfiltration at the population level remains controversial. We investigated whether higher ... -
Association of low-density lipoprotein cholesterol with risk of aortic valve stenosis in familial hypercholesterolemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)<i>Importance</i> - Aortic valve stenosis (AS) is the most common valve disease. Elevated levels of low-density lipoprotein (LDL) cholesterol are a risk factor; however, lipid-lowering treatment seems not to prevent progression of AS. The importance of LDL cholesterol in the development of AS thus remains unclear. People with familial hypercholesterolemia (FH) have elevated LDL cholesterol levels ... -
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)<i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ... -
Intrathoracic Breast Transposition: A New Method in the Treatment of Bronchopleural Fistula and Empyema
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019)A bronchopleural fistula (BF) is a life-threatening complication. Optimal management of a BF is still debated although surgery remains the preferred treatment. Usually, the fistula is a result of inadequate healing at the bronchial stump after pneumonectomy. Successful closure of a BF after pneumonectomy depends on evacuation of empyema, coverage of the suture line after fistula closure with ... -
Identifying sequence variants contributing to hereditary breast and ovarian cancer in BRCA1 and BRCA2 negative breast and ovarian cancer patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-27)Families with breast and ovarian cancer are often tested for disease associated sequence variants in <i>BRCA1</i> and <i>BRCA2</i>. Pathogenic sequence variants (PVs) in these two genes are known to increase breast and ovarian cancer risks in females. However, in most families no PVs are detected in these two genes. Currently, several studies have identified other genes involved in hereditary breast ... -
Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: A systematic review and meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-03)<i>Importance</i> - The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.<p> <p><i>Objective</i> - To assess the association between management of neonatal EOS ... -
The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-27)The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX21 in two ... -
Factors influencing growth of children aged 12-24 months in the Tanga Region, Tanzania
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)<i>Background</i> - The first 1000 days of life, from conception to the second birthday, offer a unique window of opportunity for optimal growth, critical for future health. The primary aim of this study was to analyze growth of children between 12 and 24 months age in Tanzanian children, and to explore possible predictors for growth.<p> <p><i>Methods</i> - Observational, cross-sectional study ...