dc.contributor.author | Vårtun, Åse | |
dc.contributor.author | Flo, Kari | |
dc.contributor.author | Wilsgaard, Tom | |
dc.contributor.author | Acharya, Ganesh | |
dc.date.accessioned | 2015-09-14T07:16:31Z | |
dc.date.available | 2015-09-14T07:16:31Z | |
dc.date.issued | 2015-08-10 | |
dc.description.abstract | Objective: Cardiovascular response to passive leg raising (PLR) is useful in assessing preload
reserve, but it has not been studied longitudinally during pregnancy. We aimed to investigate
gestational age associated serial changes in maternal functional hemodynamics and
establish longitudinal reference ranges for the second half of pregnancy. Materials and Methods:
This was a prospective longitudinal study on 98 healthy pregnant women who were examined
3–5 times during 20–40 weeks of gestation (a total of 441 observations). Maternal cardiac
function and systemic hemodynamics were assessed at baseline and 90 seconds after
PLR using impedance cardiography (ICG). The main outcome measures were gestational
age specific changes in ICG-derived variables of maternal cardiovascular function and functional
hemodynamic response to PLR. Results: Hemodynamic response to PLR varied during pregnancy. PLR led to an insignificant increase in stroke volume during 20+0 to 31+6 weeks, but later in gestation the stroke volume was slightly lower at PLR compared to baseline. PLR caused no significant change in cardiac output between 20+0 and 23+6 weeks and a significant decrease after 24+0 weeks. A decrease in heart rate, mean arterial pressure, and cardiac contractility was observed during PLR throughout the second half of pregnancy. Systemic vascular resistance was
reduced by PLR up to 32+0 weeks, but increased slightly thereafter. Conclusion: Healthy pregnant women appear to have limited preload reserve and reduced cardiac contractility, especially in the third trimester, which makes them vulnerable to fluid overload and cardiac failure. | en_US |
dc.description.sponsorship | This study was funded by the Regional Health Authority of Northern Norway (Helse-Nord), Grant No. SFP873/ID1646, GA. | en_US |
dc.identifier.citation | PLoS ONE 10(8): e0135300 (2015) | en_US |
dc.identifier.cristinID | FRIDAID 1259772 | |
dc.identifier.doi | 10.1371/journal.pone.0135300 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10037/8051 | |
dc.identifier.urn | URN:NBN:no-uit_munin_7640 | |
dc.language.iso | eng | en_US |
dc.publisher | Public Library of Science (PLoS) | en_US |
dc.rights.accessRights | openAccess | |
dc.subject | pregnancy | en_US |
dc.subject | Longitudinal Study | en_US |
dc.subject | Maternal Functional Hemodynamics | en_US |
dc.subject | cardiovascular response | en_US |
dc.subject | hemodynamic response | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 | en_US |
dc.title | Maternal functional hemodynamics in the second half of pregnancy: A longitudinal study | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |