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dc.contributor.authorGussgard, Anne Margrete
dc.contributor.authorJokstad, Asbjørn
dc.contributor.authorWood, Robert
dc.contributor.authorHope, Andrew
dc.contributor.authorTenenbaum, Howard
dc.date.accessioned2016-02-11T08:45:02Z
dc.date.available2016-02-11T08:45:02Z
dc.date.issued2015-06-10
dc.description.abstract<p>Background Self-reported pain and impairment of oral functions varies markedly and often in spite of extensive oral mucositis (OM). The aim of the current study was to appraise how patientreported debilitation caused by OM is influenced by the extent and possibly location of the OM lesions.<p>Methods Patients with head and neck cancer undergoing radiotherapy were examined before treatment, twice weekly during 6-7 weeks of therapy, and 3-4 weeks after therapy completion. OM signs of 33 participants were evaluated using the Oral Mucositis Assessment Scale (OMAS), while OM symptoms were recorded using Patient-Reported Oral Mucositis Symptom (PROMS)-questionnaires. Changes in OM experience as a function of OM signs was undertaken by comparing the aggregated and individual PROMS scale values at the point of transition of OMAS ulceration scores between 0 to 1, 1 to 2 and 2 to 3, respectively in the nine intra-oral locations designated in the OMAS. ANOVA with pairwise contrasts using the LSD procedure was applied for comparisons of mean changes of PROMS scale values for the participants who experienced an OMAS score of 2 or more during therapy (n=24).<p>Results Impairment of eating hard foods was more when the OMAS score for ulceration anywhere in the mouth or in the soft palate changed from 1 to 2, compared to between score 0 and 1 (p=.002 and p=.05) or between score 2 and 3 (p=.001 and p=.02). Mouth pain increased more upon transition of OMAS score anywhere in the mouth from 1 to 2 compared to 0 to 1 (p=.05).<p>Conclusion The relationship between patient-reported impairment of oral function and pain caused by OM ulceration is not linear, but rather curvilinear. Our findings should prompt investigators of future interventional trials to consider using a less severe outcome than maximum OM scores as the primary study outcome.en_US
dc.identifier.cristinIDFRIDAID 1248199
dc.identifier.doi10.1371/journal.pone.0129001
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/8462
dc.identifier.urnURN:NBN:no-uit_munin_8029
dc.language.isoengen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleSymptoms Reported by Head and Neck Cancer Patients during Radiotherapy and Association with Mucosal Ulceration Site and Size: An Observational Study.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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