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dc.contributor.authorWirsing, Anna Maria
dc.contributor.authorRikardsen, Oddveig G
dc.contributor.authorSteigen, Sonja Eriksson
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.date.accessioned2016-03-11T12:00:55Z
dc.date.available2016-03-11T12:00:55Z
dc.date.issued2015-09-17
dc.description.abstractBackground: Staging of oral squamous cell carcinoma is based on the TNM system, which has been deemed insufficient for prognostic purposes. Hence, better prognostic tools are needed to reflect the biological diversity of these cancers. Previously, high numbers of specialized blood vessels called high-endothelial venules have been reported to be associated with prolonged survival in patients with breast cancer. In this study, we analysed the prognostic value and morphological characteristics of tumour-associated high-endothelial venules in oral cancer. <p>Methods: The presence of tumour-associated high-endothelial venules was evaluated by immunohistochemistry in 75 patients with oral squamous cell carcinoma and analysed with correlation to clinicopathological parameters, patients’ survival, and vessel morphology. Ten of the samples were analysed at multiple levels to evaluate intratumoural heterogeneity. <p>Results: The presence of tumour-associated high-endothelial venules was found to be associated with lower disease-specific death in multivariate regression analyses (P=0.002). High-endothelial venules were present in all (n=53) T1-T2 tumours, but only in two-thirds (n=14) of the T3-T4 tumours. The morphology of high-endothelial venules was heterogeneous and correlated with lymphocyte density. High-endothelial venules were found to be distributed homogeneously within the tumours. <p>Conclusion: We found the presence of tumour-associated high-endothelial venules to be an easy-to-use, robust, and independent positive prognostic factor for patients with oral cancer. Absence of these vessels in advancedstage tumours might identify patients with more aggressive disease. Evaluating the presence of tumour-associated high-endothelial venules might help to tailor the treatment of oral cancer patients to their individual needsen_US
dc.descriptionAccepted manuscript version. The final publication is available at Springer via <a href=http://dx.doi.org/10.1007/s13277-015-4036-4>http://dx.doi.org/10.1007/s13277-015-4036-4</a>en_US
dc.identifier.citationTumour Biology 2015, Published ahead of printen_US
dc.identifier.cristinIDFRIDAID 1266238
dc.identifier.doi10.1007/s13277-015-4036-4
dc.identifier.issn1010-4283
dc.identifier.urihttps://hdl.handle.net/10037/8894
dc.identifier.urnURN:NBN:no-uit_munin_8455
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.rights.accessRightsopenAccess
dc.subjectOral squamous cell carcinomaen_US
dc.subjectprognostic factoren_US
dc.subjecthigh-endothelial venulesen_US
dc.subjectperipheral node addressinen_US
dc.subjectinflammationen_US
dc.subjectlymphocyte traffickingen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titlePresence of tumour high-endothelial venules is an independent positive prognostic factor and stratifies patients with advanced-stage oral squamous cell carcinomaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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