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dc.contributor.authorPostoev, Vitaly Alexandrovich
dc.contributor.authorGrjibovski, Andrej
dc.contributor.authorNieboer, Evert
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2016-03-16T09:19:11Z
dc.date.available2016-03-16T09:19:11Z
dc.date.issued2015-11-23
dc.description.abstractBackground: Prenatal diagnostics ultrasound was established in Russia in 2000 as a routine method of screening for birth defects. The aims of the current study were twofold: to assess changes in birth defects prevalence at birth and perinatal mortality after ultrasound screening was implemented and to estimate prenatal detection rates for congenital malformations in the city of Monchegorsk (Murmansk County, North-West Russia). <p>Methods: The Murmansk County Birth Registry and the Kola Birth Registry were the primary sources of information, and include 30 448 pregnancy outcomes in Monchegorsk for the period 1973–2011. Data from these registries were supplemented with information derived from hospital records about pregnancy terminations for 2000–2007. <p>Results: The total number of newborns with any kind of birth defects in Monchegorsk during 1973–2011 was 1099, of whom 816 were born in the 1973–2000 period. The prevalence of defects at birth increased from 34.2/1000 (95 % CI = 31.9-36.5) to 42.8/1000 newborns (95 % CI = 38.0-47.7) after prenatal ultrasound screening was formally implemented. We observed significant decreases (p < 0.05) in the birth prevalence of congenital malformations of the circulatory system, the musculoskeletal system (including deformations), and other (excluding multiple); those of the urinary system increased from 0.9/1000 to 17.1/1000 (p < 0.0001). The perinatal mortality among newborns with any kind of malformation decreased from 106.6 per 1000 newborns with birth defects (95 % CI = 84.3-129.1) to 21.2 (95 % CI = 4.3-38.1). Mothers who had undergone at least one ultrasound examination during pregnancy (n = 9883) had a decreased risk of having a newborn die during the perinatal period [adjusted OR = 0.49 (95 % CI = 0.27-0.89)]. The overall prenatal detection rate was 34.9 % with the highest for malformations of the nervous system. <p>Conclusion: Improved detection of severe malformations with subsequent pregnancy termination was likely the main contributor to the observed decrease in perinatal mortality in Murmansk County, Russia.en_US
dc.descriptionPublished version, also available at <a href=http://www.doi.org/10.1186/s12884-015-0747-1> http://www.doi.org/10.1186/s12884-015-0747-1</a>en_US
dc.identifier.citationBMC Pregnancy and Childbirth (2015) 15:308en_US
dc.identifier.cristinIDFRIDAID 1292928
dc.identifier.doi10.1186/s12884-015-0747-1
dc.identifier.issn1471-2393
dc.identifier.urihttps://hdl.handle.net/10037/8977
dc.identifier.urnURN:NBN:no-uit_munin_8545
dc.language.isoengen_US
dc.publisherBiomed Centralen_US
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657227/pdf/12884_2015_Article_747.pdfen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectPrenatal diagnosticsen_US
dc.subjectScreeningen_US
dc.subjectUltrasound diagnosticen_US
dc.subjectBirth defectsen_US
dc.subjectMurmansk County Birth Registryen_US
dc.subjectPerinatal mortalityen_US
dc.subjectPrenatal detection rateen_US
dc.subjectRussiaen_US
dc.titleChanges in detection of birth defects and perinatal mortality after introduction of prenatal ultrasound screening in the Kola Peninsula (North-West Russia): combination of two birth registriesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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