Bakgrunn Nordmenn brukte i 2011 nærmere 3 milliarder kroner på kosttilskudd. Undersøkelser viser at flere bruker kosttilskudd i doser som overskrider anbefalingene på pakningsvedlegget. To masteroppgaver fra 2012 viser at det kan være et potensielt overforbruk av vitaminer hos middelaldrende kvinner og at det er en sammenheng mellom sosioøkonomisk status og kosttilskuddsbruk totalt. Formål Formålet ...

Tuberculosis (TB) is an infectious disease that represents a serious global threat, with estimations suggesting that one third of the world’s population is infected. Treating TB today requires long treatment duration and medicines must be administered orally in large doses, which leads to non-compliant patients. CPZEN-45 is a novel anti-TB drug candidate in pre-clinical development, in which pulmonary ...

Bakgrunn: Det er et økt fokus på at pasienter skal kunne være med på å delta i avgjørelser rundt egen behandling. For at de skal kunne gjøre dette er det viktig at de er i stand til å innhente god å forståelig informasjon om helserelaterte tema. Tidligere har det vist seg at helsepersonell slik som lege og farmasøyt har vært kilder som brukes mest. Men i dagens samfunn er bruk av internett utbredt, ...

The GPCR CXCR4 is a chemokine receptor that by activation of its natural ligand SDF-1α is involved in the pathology of several diseases like cancer metastasis, leukemia cell progression and rheumatoid arthritis. The finding that CXCR4 plays a critical role for HIV-1 entry into T cells prompts additional motivation for the design of CXCR4 inhibitor. The establishment of the possible binding mode(s) ...

In the last decade, the investigation of marine natural products has resulted in a remarkable number of compounds with promising biological activities. Marine natural products have been shown to display antibacterial, antifungal, anticancer, antiviral, antiparasitic, anti-inflammatory activity and several other pharmacological activities of benefit to humankind. In this project, an investigation ...

Metridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms ...

Marine bioprospecting is the systematic search for and discovery of products from Nature, with potential of being developed into commercially available pharmaceuticals. The ocean represents the largest habitat on Earth, and represent a great resource of organisms with unique biological and chemical diversity. The marine environment makes the living condition challenging. To survive these conditions, ...

Calanus finmarchicus is a vast resource that until recently have been exploited to a minimal degree only. In the last few years harvesting and processing methods have been developed. There is a large market and great interest in products derived from marine oils. Most of the products today are derived from organisms at a high trophic level, i.e. products derived from cod liver oil. One disadvantage ...

From previous work, it was identified two analytes of interest, produced by Lacinutrix sp. The two analytes are iso-branched lyso-ornithine lipids with only one CH2 group differing between the two compounds, in the hydrocarbon chain (lysoC15:0 and C16:0). The bacterium was isolated from the marine sponge Halicondria sp. that was collected beside Bjørnøya, on a research cruise in 2009. The analytes ...

Marin bioprospektering er i hurtig fremmarsj både i Norge og på verdensbasis. Det kan defineres som en formålrettet og systematisk leting etter bestander, bioaktive forbindelser eller gener i marine organismer med sikte på utvikling av et produkt som er kommersielt eller samfunnsmessige viktige. Målet med denne oppgaven er å lete etter forbindelser med anticancereffekt i ekstrakter av tre ulike ...