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dc.contributor.authorMelsom, Toralf
dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorEnoksen, Inger Therese
dc.contributor.authorStefansson, Vidar Tor Nyborg
dc.contributor.authorRismo, Renathe
dc.contributor.authorJenssen, Trond
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorEriksen, Bjørn Odvar
dc.date.accessioned2021-09-13T09:22:06Z
dc.date.available2021-09-13T09:22:06Z
dc.date.issued2021-05-18
dc.description.abstract<i>Introduction</i> - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity.<br><br> <i>Methods</i> - We investigated the association of HDL-C levels with risk of GFR loss in a general population cohort; the participants were aged 50–62 years and did not have diabetes, CVD, or chronic kidney disease (CKD) at baseline. The GFR was measured using iohexol-clearance at baseline (<i>n</i>=1627) and at the follow-up (<i>n</i>=1324) after a median of 5.6 years. We also investigated any possible effect modification by low-grade inflammation, physical activity, and sex.<br><br> <i>Results</i> - Higher HDL-C levels were associated with steeper GFR decline rates and increased risk of rapid GFR decline (>3 ml/min per 1.73 m2 per year) in multivariable adjusted linear mixed models and logistic regression (–0.64 ml/min per 1.73 m2 per year [95% CI –0.99, –0.29; <i>P</i> < 0.001] and odds ratio 2.7 [95% CI 1.4, 5.2; <i>P</i> < 0.001] per doubling in HDL-C). Effect modifications indicated a stronger association between high HDL-C and GFR loss in physically inactive persons, those with low-grade inflammation, and men.<br><br> <i>Conclusion</i> - Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.en_US
dc.identifier.citationMelsom, Norvik, Enoksen, Stefansson, Rismo, Jenssen, Solbu, Eriksen. Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population. Kidney International Reports. 2021:1-11en_US
dc.identifier.cristinIDFRIDAID 1924237
dc.identifier.doi10.1016/j.ekir.2021.05.007
dc.identifier.issn2468-0249
dc.identifier.urihttps://hdl.handle.net/10037/22499
dc.language.isoengen_US
dc.publisherInternational Society of Nephrologyen_US
dc.publisherElsevieren_US
dc.relation.journalKidney International Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAssociation of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Populationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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