Malignant melanoma is the deadliest form of skin cancer, and successful treatment relies on early detection. Undiagnosed skin lesions can be photographed and the images fed into a computer system that potentially differentiates malignant from benign lesions. To develop the melanoma detection system, various methods from statistics, machine learning and image analysis are applied. An image consists ...

With the accelerated advances in sequencing technology the last decade, the field of metagenomics has progressed immensely. Sampling and sequencing of metagenomic data is now prevalent, and publicly available data sets from mundane soil and water environments to exotic niche habitats such as geothermal hot springs are readily available through sequence data repositories such as the European Nucleotide ...

Carbapenemases are enzymes able to hydrolyze the last resort b-lactam antibiotics (carbapenems), which are used for the treatment of infections caused by resistant bacteria. Carbapenemases are structurally and mechanistically classified into serine-b-lactamases (SBLs) and metallo-b-lactamases (MBLs). In order to combat the hydrolytic activity of these enzymes, combination therapy of b-lactam with ...

In northern Norway, late/post-Caledonian extension initiated along inverted, brittle-ductile thrusts, e.g. Sørøya-Ingøya shear zone, which truncated existing, margin-oblique, late Neoproterozoic, Timanian faults and margin-parallel, latest Mesoproterozoic-mid Neoproterozoic faults related to the opening of the Asgard Sea and Iapetus Ocean. Inverted thrusts were active through the Devonian and early ...

Using a time-dependent numerical model that spans the chromosphere, corona and solar wind, abundance variations resulting from gravitational settling in the chromosphere and corona have been studied. \noindent Gravitational settling in the chromosphere may lead to a depletion in the abundances of minor elements in the solar wind relative to the photosphere. The observed overabundance (relative ...

This thesis summarizes six years of design, development and evaluation of a model- driven development toolchain and design of software services for continuity of care. The overall research method has been design science, with a strong focus on creating and evaluating the core artefact: the ModelHealth Toolchain. Three iterations with toolchain design and assessments were deemed necessary to be able ...

Ice dynamics are strongly controlled by processes taking place at the interface between the ice and the underlying bed. In modern day ice sheets, up to 90% of mass is lost through fast-flowing corridors of ice, called ice streams. These are typically underlain by a thin layer of water and wet sediment, both of which promote fast flow. In recent years it has emerged that subglacial hydrology played ...

Ships operating in a cold climate face many challenges. There are several associated risks such as safety concerns, down time, energy consumption and limited resources. Amongst the key challenges, ship ice accretion is significant for cold climate operations. Exposing superstructures to the marine icing phenomenon can affect the ship’s operations, risking the safety of humans and machines. In this ...

This thesis deals with polarimetric multi-frequency radar signatures of sea ice. It presents a thorough background on the topic and three case studies. The first study presents a global sensitivity analysis of the fully polarimetric radar backscatter response from snow covered sea ice. The analysis is global in the sense that it takes into account the observed ranges of sea ice properties that ...

Two sediment cores and several sediment surface samples have been retrieved in order to develop and apply benthic foraminifera as proxies in the Polar North Atlantic. The purpose of the surface samples was to develop the Mg/Ca method for cold water environments, as this has been proven a valuable paleo-thermometer for several marine environments. This was done for three species of Benthic foraminifera: ...