Blar i utgivelsesdato Institutt for medisinsk biologi
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Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-10-24)This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional ... -
Downstream gene expression of wild type p53 tumor suppressor gene versus mutated and null p53
(Master thesis; Mastergradsoppgave, 2006-11)P53 is a key tumor suppressor and transcription factor protecting us from cancer. The wild type p53 protein functions as a regulatory protein, triggering a variety of cellular responses to different signals. Activation of p53 can lead to cell division arrest, DNA repair, or apoptosis. More than 60% of all human cancers contain p53 mutations. P53 is also reported in many studies to play a role in the ... -
The 5-HT1E receptor. Receptor structure and ligand interactions.
(Master thesis; Mastergradsoppgave, 2006-12-08)5-HT (5-Hydroxytryptamine; Serotonin) is the neurotransmitter with the highest number of known receptors in humans, and the importance of 5-HT is also reflected in the number of species using 5-HT as a signalling molecule and the number of 5-HT receptors found within each species. 15 human 5-HT receptors have at this date been characterised and classified into seven 5-HT receptor families. Six of ... -
Intensity Dependent Confidence Intervals on Microarray Measurements of Differentially Expressed Genes : A Case Study of the Effect of MK5, FKRP and TAF4 on the Transcriptome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007) -
Researching complementary and alternative treatments : the gatekeepers are not at home
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007) -
Risk assessment on the use of triclosan in cosmetics; Development of antimicrobial resistance in bacteria - II. Opinion of the Panel on Biological Hazards Norwegian Scientific Committee for Food Safety
(Research report; Forskningsrapport, 2007-02)Den Europa kommisjonens vitenskapskomité for forbruksvarer (SCCP) konkluderte 10. oktober 2006 med at det på grunnlag av tilgjengelige data ikke er funnet bevis for at triklosan i kosmetiske produkter kan føre til resistens – eller kryssresistensutvikling hos bakterier. Til tross for at en slik sammenheng kan være sannsynlig, finnes det ikke god dokumentasjon.<p><p> Siden denne konklusjonen ikke ... -
Oppdatert risikovurdering – introduksjon av høypatogent aviært influensavirus til Norge våren 2007
(Research report; Forskningsrapport, 2007-02-15)VKM ga i 2006 to risikovurderinger vedrørende introduksjon av høypatogent aviært influensavirus til Norge. Den foreliggende vurderingen er en oppdatering av disse vurderingene og besvarer spørsmål om risiko i ulike situasjoner i Norge våren 2007. -
A mitogenomic approach to the taxonomy of pollocks. Theragra chalcogramma and T. finnmarchica represent one single species
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-06-07)Background: The walleye pollock (Theragra chalcogramma) and Norwegian pollock (T. finnmarchica) are confined to the North Pacific and North Atlantic Oceans, respectively, and considered as distinct species within the family Gadidae. We have determined the complete mtDNA nucleotide sequence of two specimens of Norwegian pollock and compared the sequences to that of 10 specimens of walleye pollock ... -
Risk assessment on use of Lactobacillus rhamnosus (LGG) as an ingredient in infant formula and baby foods (II)
(Research report; Forskningsrapport, 2007-06-15)On 10. March 2006 , The Norwegian Food Safety Authority (Mattilsynet) decided that, on the basis of VKM’s previous risk assessment (2005), Nutramigen 1 with Lactobacillus rhamnosus GG (LGG) could not be marketed in Norway as medical foods for infants (0-4 months). In addition, The Norwegian Food Safety Authority (Mattilsynet) decided (08. November ... -
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-06)Background: Multidrug resistance is a particular limitation to cancer chemotherapy, antibiotic treatment and HIV medication. The ABC (ATP binding cassette) transporters human P-glycoprotein (ABCB1) and the human MRP5 (ABCC5) are involved in multidrug resistance. Results: In order to elucidate structural and molecular concepts of multidrug resistance, we have constructed a molecular model of the ... -
Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-08)Background: Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other ... -
Risikovurdering; import og spredning av tarmpatogene bakterier med krydder og urter
(Research report; Forskningsrapport, 2007-09-26)Forbruket av krydder i Norge øker og ligger per i dag på vel ½ kg per person og år (2006). Forbruket hos oss er imidlertid fortsatt langt lavere enn i enkelte andre industriland (eksempelvis USA med et forbruk på 1,6 kilo per person og år) og vil derfor sannsynligvis fortsatt øke ganske betydelig. Også antall ulike kryddertyper øker, parallelt med økende interesse for ”eksotisk” (ikke minst asiatisk) ... -
Fatal inanition in reindeer (Rangifer tarandus tarandus) : pathological findings in completely emaciated carcasses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-28)Background: In a project to determine the causes of winter mortality in reindeer in Finnmark County, northern Norway, the most frequent diagnosis turned out to be complete emaciation, despite several of the reindeer having been given silage for up to 4 weeks before they died. The present paper describes autopsy results and other findings in these animals. Methods: Autopsies were made of 32 ... -
Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-11-12)Background The mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5, we constructed ... -
Improvement of wound healing by water-filtered infrared-A (wIRA) in patients with chronic venous stasis ulcers of the lower legs including evaluation using infrared thermography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
PHI-base update : additions to the pathogen-host interaction database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
Therapy of chronic wounds with water-filtered infrared-A (wIRA)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
Use of Complementary and Alternative Medicine Among Patients: Classification Criteria Determine Level of Use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)Background and objectives: Self-reported use of complementary and alternative medicine (CAM) among patients varies widely between studies, possibly because the definition of a CAM user is not comparable. This makes it difficult to compare studies. The aim of this study is to present a six-level model for classifying patients' reported exposure to CAM. Prayer, physical exercise, special diets, ... -
A prospective study of maternal anti-HPA1a antibody level as a potential predictor for alloimmune thrombocytopenia in the newborn
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
Changes in antacid use over a 9-year period in a general population adjusted for changes in dyspeptic complaints
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)