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Now showing items 4696-4715 of 10125
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In vitro Candida albicans biofilm formation on different titanium surface topographies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)<i>Objectives</i> - To investigate if differences in titanium implant surface topography influence <i>Candida albicans</i> biofilm formation.<p> <p><i>Materials and Methods</i> - Titanium discs were prepared and characterized using a profilometer: Group A (<i>R</i><sub>a</sub> 0.15 µm, smooth), Group B (<i>R</i> <sub>a</sub> 0.64 µm, minimally rough) and Group C (<i>R</i> <sub>a</sub> 1.3 µm, ... -
In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)<p><i>Background</i>: Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers that can forecast the clinical potency of the cells have been proposed, but evidence for the relationship between in ... -
In vitro effects of alcohol and oxidative stress on sperm cell motility and viability
(Master thesis; Mastergradsoppgave, 2020-08-28)The deteriorating semen quality is one of the increasing problems of male reproductive health worldwide and the exact cause of this has not been fully understood yet. Many stress factors may affect semen quality such as sperm cell motility and viability and thus impair the fertilization outcome. Among the different stress factors, alcohol can inhibit steroidogenesis, suppresses LH release from the ... -
In vitro fertilisering Tromsø : utvikling av et blastocystregime og resultater i to karakteristiske perioder
(Master thesis; Mastergradsoppgave, 2010-09)Bakgrunn: In vitro fertiliseringsklinikken ved Universitetssykehuset i Nord Norge har vært sterkt delaktig i utviklingen av et regime til bruk i klinisk in vitro fertilisering som går ut på å dyrke embryo i langtidskultur i fem dager til blastocyster. Dette for å selektere de mest levedyktige embryoene for tilbakeføring ved å observere hvilke embryoer som utvikler seg best og ekskludere de som ... -
In vitro generation of functional liver organoid-like structures using adult human cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-21)In this study we used differentiated adult human upcyte1 cells for the in vitro generation of liver organoids. Upcyte1 cells are genetically engineered cell strains derived from primary human cells by lenti-viral transduction of genes or gene combinations inducing transient proliferation capacity (upcyte1 process). Proliferating upcyte1 cells undergo a finite number of cell divisions, i.e., ... -
In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ... -
In vitro micro-CT analyse av demineraliseringslesjoner på emaljeoverflaten
(Mastergradsoppgave; Master thesis, 2020-05-20)Målsetting: Målet med dette masterforsøket er å danne demineraliseringslesjoner som ligner på initialkaries ved hjelp av 4 ulike syreløsninger på emaljeoverflaten in vitro, og deretter sammenlikne bildene utfra de diagnostiske kriteriene, definert under, for å se hvilken som gir det beste resultatet. Metode: 40 tenner ble samlet inn fra UTK og TkNN, hvor deretter 12 tenner ble randomisert valgt ut ... -
In vitro permeation models for healthy and compromised skin: The Phospholipid Vesicle-based Permeation Assay (PVPA) for skin applications
(Doctoral thesis; Doktorgradsavhandling, 2015-03-20)In vitro models with the ability to estimate drug penetration through healthy and compromised skin may reduce animal testing of drugs and cosmetics to a minimum. The phospholipid vesicle based permeation assay (PVPA) is based on a tight barrier composed of liposomes mimicking cells. It was originally made to mimic the intestinal epithelial barrier and in this project further developed to mimic the ... -
In vitro reconstitution of proMatrix Metalloproteinase-9/Chondroitin Sulfate Proteoglycan Complexes. Identification of motifs in proMMP-9 and the serglycin core protein involved in the complex formation.
(Master thesis; Mastergradsoppgave, 2014-05-15)Previously it has been shown that different monocytic leukemic cell lines such as THP-1, MonoMac and U-937 can produce proteolytic enzymes such as MMP-9 as well as various types of proteoglycans (PG). These proteins have been shown to be involved in homeostasis as well as in various diseases, such as cancer. When proMMP-9 was mixed with isolated PGs from these three cell lines or pure serglycin and ... -
In vitro skin models as a tool in optimization of drug formulation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-30)(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the ... -
In vivo perforasome perfusion in hemi-DIEP flaps evaluated with indocyanine-green fluorescence angiography and infrared thermography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)Background: There are no in vivo studies that evaluate the effect of perforator dissection on the perfusion territory of a perforator (perforasome). In this study, indocyanine green fluorescence angiography (ICG-FA) and infrared thermography (IRT) were used intraoperatively to evaluate perforasome perfusion in hemi-DIEP flaps.<p> <p>Methods: Patients selected for DIEP breast reconstruction were ... -
In Your Face: Startle to Emotional Facial Expressions Depends on Face Direction.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01)Although faces are often included in the broad category of emotional visual stimuli, the affective impact of different facial expressions is not well documented. The present experiment investigated startle electromyographic responses to pictures of neutral, happy, angry, and fearful facial expressions, with a frontal face direction (directed) and at a 45 angle to the ... -
An in-depth implementation study of the Greenlandic parenting program MANU’s initial stages of implementation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-22)In Greenland, the universal parenting programme MANU was developed in 2016. After documenting the initial years of MANU’s implementation, this study aimed to identify implementation determinants focusing on i) which context MANU was conceptualised in and how it was developed and ii) how MANU was implemented and initially received in the healthcare system. A qualitative in-depth implementation ... -
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-18)Background: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. <br>Methods: Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for ... -
The incidence and prevalence of Chronic Fatigue Syndrome, Back Pain of unknown origin, Fibromyalgia, and Myalgia in Norwegian women, and their association to physical activity. A prospective cohort study of material from the Norwegian Women and Cancer (NOWAC) study.
(Master thesis; Mastergradsoppgave, 2014-05-01)Background: Musculoskeletal disorders (MSDs) appear relatively frequent and are costly for society each year, yet they are poorly understood. Four commonly occurring MSDs are Chronic Fatigue Syndrome (CFS), Back Pain (BP) of unknown origin, Fibromyalgia (FM), and muscle pain/Myalgia. There are few Norwegian epidemiologic data on these four outcomes. Physical activity (PA) has been internationally ... -
Incidence and progression of dental erosion among adolescents in Troms. Data based on Fit Futures - a health survey among adolescents
(Master thesis; Mastergradsoppgave, 2015-05-18)Caries and periodontitis has for a long time been the main concern among dental practitioners and a lot of research has been directed towards the management of these oral diseases. An improvement of oral health has been observed in most industrialized countries during the last 40 years, mostly due to a decline in caries prevalence in the western part of the world. However, during the last 15 years ... -
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)Introduction - Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary Stent Trial (NORSTENT). <p> <p>Materials and methods - NORSTENT was a randomized, double blind, pragmatic trial among patients with acute coronary syndrome or stable coronary ... -
Incidence and Risk Factors of Pre-Eclampsia in the Paropakar Maternity and Women's Hospital, Nepal: A Retrospective Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)This study aims to determine the incidence of pre-eclampsia and distribution of risk factors of pre-eclampsia at Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. A retrospective study included 4820 pregnant women from 17 September to 18 December 2017. Data were obtained from the medical records of the hospital’s Statistics Department. Associations between the risk factors and pre-eclampsia ... -
Incidence and risk factors of pre-eclampsia in the Paropakar Maternity and Women’s Hospital, Nepal: a retrospective study
(Master thesis; Mastergradsoppgave, 2018-05-30)Objective: To determine the incidence of pre-eclampsia and distribution of risk factors for pre-eclampsia in Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. Methods: A retrospective study was conducted that included a total of 4820 deliveries from September 17 to December 18, 2017. Data were obtained from the medical records in the hospital’s Statistics Department. Associations between ... -
Incidence and Risk Factors of Pulmonary Hypertension After Venous Thromboembolism: An Analysis of a Large Health Care Database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-15)Background<p> <p>Pulmonary hypertension (PH) is a devastating potential complication of pulmonary embolism, a manifestation of venous thromboembolism (VTE). The incidence of and risk factors for PH in those with prior VTE are poorly characterized. <p>Methods and Results <p>International Classification of Diseases (ICD) codes from inpatient and outpatient medical claims from MarketScan administrative ...
