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    • Antibiotikaresistens - konsekvenser for pasient og samfunn 

      Pedersen, Silje Elisabeth (Master thesis; Mastergradsoppgave, 2004)

    • Antibiotikaresistens - kunnskapshull, utfordringer og aktuelle tiltak. Rapport fra tverrsektoriell ekspertgruppe 

      Steinbakk, Martin; Sunde, Marianne; Urdal, Anne Margrete; Barkbu, Kjersti Nilsen; Sørum, Henning; Lunestad, Bjørn Tore; Bonhorst, Janne Øvrebø; Nielsen, Kaare Magne; Lindbæk, Morten; Bjørnholt, Jørgen (Research report; Forskningsrapport, 2014)

    • Antibiotikaresistens - Kunnskapshull, utfordringer og aktuelle tiltak. Status 2020. 

      Simonsen, Gunnar Skov; Berdal, Jan-Erik; Grave, Kari; Juvet, Lene Kristine; Lunestad, Bjørn Tore; Riisberg, Ingvild; Rørtveit, Guri; Urdahl, Anne Margrete; Årdal, Christine Oline (Research report; Forskningsrapport, 2021)
      Antimikrobiell resistens (AMR) er en global trussel mot helse og velferd hos mennesker og dyr. Den grunnleggende forståelsen av AMR har ikke endret seg over det siste tiåret, men vi har fått mer detaljert innsikt i hvordan resistens oppstår, selekteres og kan spre seg innad hos og mellom mennesker, dyr og i miljøet. Det er nødvendig å se utfordringene knyttet til AMR i et helhetlig Én helse - ...

    • Antibiotikaresistens som folkehelseproblem. Hva betyr det i et folkehelseperspektiv? 

      Rønbeck, Karl Fredrik (Master thesis; Mastergradsoppgave, 2015-06-01)
      Bakgrunn: Intensjonen med oppgaven er primært å undersøke hvilke konsekvenser antibiotikaresistens har i et samfunn – utgjør det et folkehelseproblem? I denne konteksten er det derfor interessant å ta for seg hvordan resistens påvirker morbiditeten, mortaliteten og økonomien i et samfunn. Sekundært vil det undersøkes om Norge faktisk er et foregangsland når det gjelder bruk av antibiotika i forhold ...

    • Antibiotikaresistens- et økende samfunnsmedisinsk problem : Utvikling, bidraende faktorer, konsekvenser og utfordringer 

      Utsi, Risten Inga; Guttorm, Anne Maret (Master thesis; Mastergradsoppgave, 2008-09-15)
      Hovedgrunnene for valg av tema for oppgaven var at antibiotikaresistens er et høyaktuelt tema, samtidig som kunnskap som vi skaffer oss gjennom arbeidet med oppgaven vil være til stor hjelp for oss på vår vei til, og som, utdannede leger. Antibiotikaresistens oppstår ved ulike biokjemiske eller genetiske mekanismer, slik at det er forskjell på hvordan resistens utvikles mot de forskjellige ...

    • Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma 

      Unruh, Dusten; Ünlü, Betü; Lewis, Clayton S.; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A.; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J.; Ramchandani, Divya; Weber, Georg F.; Rak, Janusz W.; Wolberg, Alisa S.; Mackman, Nigel; Versteeg, Henri H.; Bogdanov, Vladimir Y. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promotes tumor growth, metastatic spread, and monocyte recruitment to the stroma. In this study, we determined ...

    • Anticancer activity of amphipathic barbiturates 

      von Hofsten, Susannah (Doctoral thesis; Doktorgradsavhandling, 2023-06-20)
      Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ...

    • Anticancer activity of bovine lactoferricin and a cytolytic 9-mer peptide : from milk to cancer vaccine? 

      Berge, Gerd (Doctoral thesis; Doktorgradsavhandling, 2009-12-09)
      Cationic antimicrobial peptides (CAPs) are found in many diverse species playing a part in the innate immune system. CAPs are important as antimicrobial agents in most organisms, being able to kill a wide range of bacteria as well as fungi, enveloped viruses and protozoa. Certain CAPs also exhibit direct cytotoxic activity against many different types of human cancer cells. Bovine lactoferricin ...

    • The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells 

      Fadnes, Bodil Irene; Rekdal, Øystein; Uhlin-Hansen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-06-15)
      Background: Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We have previously shown that CAPs interact with the two glycosaminoglycans (GAGs), ...

    • Anticancer effekt fra marine antimikrobiellepeptider på nevroblastomcellelinjer. 

      Kjuul, Anita Kristin (Master thesis; Mastergradsoppgave, 2005)

    • Anticausatives are semantically reflexive in Norwegian but not in English 

      Lundquist, Bjørn; Corley, Martin; Tungseth, Mai; Sorace, Antonella; Ramchand, Gillian C (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-29)
      In this paper we will discuss cross-linguistic variation in semantic entailment patterns in causa- tive alternations. Previous work has probed this issue with data from elicited semantic judge- ments on paired linguistic forms, often involving linguistic negation and contradiction. We contribute to the debate in the form of a related psycholinguistic experiment that taps into direct judgements ...

    • The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial 

      Ørbo, Marte Christine; Grønli, Ole Kristian; Larsen, Camilla; Vangberg, Torgil Riise; Friborg, Oddgeir; Turi, Zsolt; Mittner, Matthias Bodo; Csifcsak, Gabor; Aslaksen, Per M (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-02)
      Background Intermittent theta burst stimulation (iTBS) when applied over the left dorsolateral prefrontal cortex (DLPFC) has been shown to be equally effective and safe to treat depression compared to traditional repetitive transcranial magnetic stimulation (rTMS) paradigms. This protocol describes a funded single-centre, double-blind, randomized placebo-controlled, clinical trial to investigate ...

    • Antidepressant use and risk of myocardial infarction A longitudinal investigation of sex-specific associations in the HUNT study 

      Karlsen, Håvard Rudi; Løchen, Maja-Lisa; Langvik, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01)
      Objective - Antidepressants are thought to affect the risk of cardiovascular disease, although the nature of the association is unclear. Men and women have unique cardiovascular risk factors, and sex differences in depression as well as the efficacy of antidepressants are important to consider. We examined whether antidepressant use was associated with risk of having a myocardial infarction (MI) and ...

    • Antiepileptic drugs for chronic neuropathic pain 

      Lagerlöf, Anders Joakim (Master thesis; Mastergradsoppgave, 2015-05-29)
      Neuropathic pain is caused by damage or disease that affects the somatosensory nervous system, where the nerves react abnormal to small or no stimuli at all and produces pain. It is less understood than nociceptive pain arising from a healthy nervous system and hence is a notoriously hard condition to treat. Neuropathic pain tends to be chronic with an average duration of 7 years [1]. The cost to ...

    • Antigen-specific humoral immune responses in vitro 

      Gabler, Marie (Master thesis; Mastergradsoppgave, 2021-05-31)
      Introduction: FNAIT is a condition were the immune system of a pregnant woman is activated and produces antibodies against an unborn child’s blood platelets. The mechanisms behind the activation of the B-cells remain unknown. The purpose of this research was to look at antigen-specific humoral immune responses associated with FNAIT. Our goal was to activate antigen-specific B-cells in vitro. Method: ...

    • Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics 

      Juskewitz, Eric (Doctoral thesis; Doktorgradsavhandling, 2022-08-12)
      Infections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, ...

    • Antimicrobial resistance acquisition via natural transformation: context is everything 

      Winter, Macaulay; Buckling, Angus; Harms, Klaus; Johnsen, Pål Jarle; Vos, Michiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)
      Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. Although this mechanism is known to mediate the uptake of antibiotic resistance determinants in a range of human pathogens, its importance in the spread of antimicrobial resistance is not always appreciated. ...

    • Antimicrobial resistance and bacterial diversity in Arctic environments 

      Glad, Trine (Doctoral thesis; Doktorgradsavhandling, 2011-06-01)
      Ampicillin er et antibiotikum som har vært brukt i flere tiår, og det er mange bakterier på sykehus og andre helseinstitusjoner som har utviklet resistens mot dette legemiddelet. Bakteriene blir resistente ved selv å utvikle eller ta opp resistensgener. Vi vet lite om bakteriene utenfor sykehusmiljøene har resistensgener mot ampicillin. Kunnskap om resistensgener i miljø hvor det er lite menneskelig ...

    • Antimicrobial susceptibility and body site distribution of community isolates of coagulase-negative staphylococci 

      Cavanagh, Jorunn Pauline; Wolden, Runa; Heise, Philipp; Esaiassen, Eirin; Klingenberg, Claus; Aarag, Elizabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-07)
      The primary aim of this study was to determine antimicrobial resistance in coagulase-negative staphylococci (CoNS) from healthy adults in the community. Healthy adults (n = 114) were swabbed on six body sites; both armpits, both knee pits and both sides of the groin. Species determination was performed using Matrix Assisted Laser Desorption Ionization – Time of Flight (MALDI-TOF) and susceptibility ...

    • Antimicrobial susceptibility profiles of clinically important bacterial pathogens at the Kamuzu Central Hospital in Lilongwe, Malawi 

      Choonara, Faheema E.; Haldorsen, Bjørg; Ndhlovu, Isaac; Saulosi, Osborne; Maida, Tarsizio; Lampiao, Fanuel; Simonsen, Gunnar Skov; Essack, Sabiha Y.; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Background The aim of this prospective study was to ascertain antimicrobial resistance (AMR) in clinical bacterial pathogens from in-hospital adult patients at a tertiary hospital in Lilongwe, Malawi. Methods<p> <p>Clinical specimens (blood culture, pus, urine and cerebrospinal fluid) collected during June to December 2017 were examined for bacterial growth in standard aerobic conditions. One ...