Browsing Det helsevitenskapelige fakultet by Title

Now showing items 5646-5665 of 10152

    • Longitudinal analyses of cardiovascular risk factors : the Tromsø study 1974-1995 

      Wilsgaard, Tom (Doctoral thesis; Doktorgradsavhandling, 2002)
      The present study has addressed longitudinal changes in cardiovascular risk factors and also assessed the association between BMI change with changes in other risk factors. We showed a moderate to high degree of tracking for systolic and diastolic blood pressure, HDL cholesterol, total cholesterol, and triglycerides and a higher degree of tracking for BMI. Tracking was higher for total cholesterol ...

    • Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016 

      Hopstock, Laila Arnesdatter; Bønaa, Kaare; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-21)
      Objectives: <br> Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studies show a cholesterol decline in recent decades but lack data to follow individuals born ...

    • Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease 

      Nordengen, Kaja; Kirsebom, Bjørn-Eivind Seljelid; Richter, Grit; Pålhaugen, Lene; Gisladottir, Berglind; Siafarikas, Nikias Ioannis; Nakling, Arne Exner; Rongve, Arvid; Bråthen, Geir; Grøntvedt, Gøril Rolfseng; Gonzalez, Fernando; Waterloo, Knut; Sharma, Kulbhushan; Karikari, Thomas; Vromen, Eleonora M.; Tijms, Betty M.; Visser, Pieter J.; Selnes, Per; Kramberger, Milicia G.; Winblad, Bengt; Blennow, Kaj; Fladby, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      Background - Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal clinical studies that include biomarker negative healthy controls and cases with established AD pathology. Here, we employ longitudinally sampled cerebrospinal fluid (CSF) core AD, ...

    • Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study 

      Allaoui, Giovanni; Rylander, Charlotta; Averina, Maria; Wilsgaard, Tom; Fuskevåg, Ole Martin; Berg, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-11)
      Introduction: Identification of individuals at high risk of developing type 2 diabetes mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and increased mortality. We aimed to describe pre- and post-diagnostic changes in blood biomarker concentrations over 30 years in individuals ...

    • Longitudinal changes in body composition and waist circumference by self-reported levels of physical activity in leisure among adolescents: the Tromsø Study, Fit Futures 

      Aars, Nils Abel; Jacobsen, Bjarne Koster; Morseth, Bente; Emaus, Nina; Grimsgaard, Sameline (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-17)
      <p><i>Background - </i>It is not clear how physical activity affects body composition in adolescents. Physical activity levels are often reduced during this period, and the relative proportion of body fat mass and lean mass undergo natural changes in growing adolescents. We aimed to examine whether self-reported physical activity in leisure time at baseline or change in activity during follow-up ...

    • Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Wilsgaard, Tom; Averina, Maria; Sandanger, Torkjel M; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to ...

    • Longitudinal changes in desired body weight compared to changes in body weight: evidence of adaptation to weight gain? 

      Aars, Nils Abel; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-21)
      <b>Background: </b>Overweight individuals desire a lower weight than they actually have. Little is known on the extent to which this discrepancy is reduced over time due to adaptation or resignation. The aim of this study is to describe cross-sectional relationships and longitudinal changes in desired body weight and differences between actual and desired body weight according to gender, age and ...

    • Longitudinal changes in forearm bone mineral density in women and men from 25 to 84 years. The Tromsø Study 

      Emaus, Nina (Doctoral thesis; Doktorgradsavhandling, 2006)

    • Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress 

      Lindgren, Lenita; Bergdahl, Jan; Nyberg, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Hippocampal volume has been found to be smaller in individuals with stress-related disorders, but it remains unclear whether smaller volume is a consequence of stress or rather a vulnerability factor. Here, we examined this issue by relating stress levels to hippocampal volumes in healthy participants examined every 5 years in a longitudinal population-based study. Based on scores of 25- to ...

    • A longitudinal follow-up of autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Oftedal, Bergithe Eikeland; Landegren, Nils; Erichsen, Martina Moter; Bratland, Eirik; Lima, Kari; Jørgensen, Anders Palmstrøm; Myhre, Anne Grethe; Svartberg, Johan; Fougner, Kristian J; Bakke, Åsne; Nedrebø, Bjørn Gunnar; Mella, Bjarne; Breivik, Lars Ertesvåg; Viken, Marte K; Knappskog, Per; Cuida Marthinussen, Ileana Mihaela; Løvås, Kristian; Kämpe, Olle; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-02)
      <b>Context:</b> Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insuffi- ciency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up of APS1 is sparse. <b>Objective:</b> To describe the phenotypes of APS1 and correlate the ...

    • A longitudinal investigation of immigrant children’s ethnic and national identities 

      Froehlich, Laura; Martiny, Sarah E.; Deaux, Kay (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-22)
      How immigrants define their ethnicity and nationality is relevant for integration: They can identify with their ethnic group, the receiving society, and a combination of both. A longitudinal study with elementary-school children with migration background (N = 200; age 9-10) in Germany investigated the predictors and stability of ethnic and national identity. Ethnic identity was more highly endorsed ...

    • Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions 

      Røe, Kathrine; Seierstad, Therese; Kristian, Alexandr; Mikalsen, Lars Tore G; Mælandsmo, Gunhild; van der Kogel, Albert; Ree, Anne Hansen; Olsen, Dag Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-10)
      Prostate cancer (PCa) patients receive androgen-deprivation therapy (ADT) to reduce tumor burden. However, complete eradication of PCa is unusual, and recurrent disease is evident within approximately 2 years in high-risk patients. Clinical evidence suggests that combining ADT with radiotherapy improves local control and disease-free survival in these patients compared with radiotherapy alone. ...

    • Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia 

      Nystad, Mona; Sitras, Vasilis; Flo, Kari; Widnes, Christian; Vårtun, Åse; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ...

    • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

      Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
      <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...

    • A Longitudinal Study of Semantic Networks in Schizophrenia and other Psychotic Disorders Using the Word Association Task 

      Pintos, Andrea Stephanie; Hui, Christy Lai-Ming; De Deyne, Simon; Cheung, Charlton; Ko, Wai Tung; Nam, Suen Yi; Chan, Sherry Kit-Wa; Chang, Wing-Chung; Lee, Edwin Ho-Ming; Lo, Alison Wai-Fan; Lo, Tak-Lam; Elvevåg, Brita; Chen, Eric Yu-Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-24)
      The underpinnings of language deviations in psychotic symptoms (eg, formal thought disorder, delusions) remain unclear. We examined whether the semantic networks underlying word associations are useful predictors of clinical outcomes in psychosis. Fifty-one patients with schizophrenia and other psychotic disorders and 51 matched healthy controls generated words in a Cantonese continued word ...

    • A longitudinal study of the changes in BMI, waist circumference, waist-to-height-ratio and desired BMI of the participants in the 4th, 5th and 6th survey of the Tromsø Study. 

      Aars, Nils Abel (Master thesis; Mastergradsoppgave, 2014-04-29)
      Background: prevalence of obesity and overweight continues to increase in Norway, and more in young than old. This thesis has sought to describe the changes in BMI, with supplementary analyses of WC and WHtR, over a 13-year period. Furthermore, desired BMI (DBMI) has been analysed to assess whether the discrepancy between weight and desired weight is dependent on BMI categories of normal weight, ...

    • Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort. 

      Glerup, Mia; Stoustrup, Peter Bangsgaard; Matzen, Louise Hauge; Rypdal, Veronika Gjertsen; Nordal, Ellen Berit; Frid, Paula; Arnstad, Ellen Dalen; Rygg, Marite; Thorarensen, Olafur; Ekelund, Maria; Berntson, Lillemor; Fasth, Anders; Nilsson, H; Peltoniemi, Suvi; Aalto, Kristiina; Arte, Sirpa; Toftedal, Peter; Nielsen, Susan; Kreiborg, S.; Herlin, T; Pedersen, T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
      <i>Objective</i> - To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.<p> <p><i>Methods</i> - Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ ...

    • A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii 

      Semmler, Torsten; Harrison, Ewan M.; Lübke-Becker, Antina; Ulrich, Rainer G.; Wieler, Lothar H.; Guenther, Sebastian; Stamm, Ivonne; Hanssen, Anne-Merethe; Holmes, Mark A.; Vincze, Szilvia; Walther, Birgit (Journal article; Tidsskriftartikkel, 2016-01-22)
      INTRODUCTION Horizontal gene transfer (HGT) is an important driver for resistance- and virulence factor accumulation in pathogenic bacteria such as Staphylococcus aureus. METHODS Here, we have investigated the downstream region of the bacterial chromosomal attachment site (attB) for the staphylococcal cassette chromosome mec (SCCmec) element of a commensal mecC-positive Staphylococcus ...

    • Loss of deuterium in faecal solids and by sequestration in reindeer. Effect on doubly labelled water studies. 

      Milne, Eric; Gotaas, Geir; Haggarty, Paul; Tyler, Nicholas J.C. (Journal article; Peer reviewed; Tidsskriftartikkel, 2000)

    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...