LTX-315 is a nonameric oncolytic peptide in early clinical development for the treatment of solid malignancies. Preclinical and clinical evidence indicates that the anticancer properties of LTX-315 originate not only from its ability to selectively kill cancer cells, but also from its capacity to promote tumortargeting immune responses. Here, we investigated the therapeutic activity and immunological ...

Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family ...

The accuracy of individual clinical index tests used to predict imaging findings of nerve root impingement in patients with chronic lumbar radiculopathy is low when applied in specialized care, but clinicians’ overall evaluation improves diagnostic accuracy slightly. The diagnostic accuracy of individual index tests was low with no tests reaching positive LR >4.0 or negative LR <0.4. The overall ...

Background: Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution. Methods: We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air pollution in never smokers and ex-smokers ...

<b>Bakgrunn</b>: Fødsel før 32. svangerskapsuke medfører stor risiko for pulmonal morbiditet. Ved fødsel i en sårbar fase av lungeutviklingen er respirasjonsstøttende behandling nødvendig for å sikre overlevelse. Formålet med denne studien er å kartlegge forekomsten av de vanligste lungesykdommene og den respirasjonsstøttende behandlingen hos barn født før uke 32. <p> <p><b>Metode</b>: Studien ...

FcγRIIB^-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have investigated nephritis development and progression in FcγRIIB^-/-yaa mice to find shared features with NZB/NZW F1 lupus prone mice and human disease. We sacrificed 25 male ...

Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human ...

Background In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor. Several mediating factors have been implied in the development of nodal metastases and investigated for predictive and prognostic properties in NSCLC. However, study results differ. In this structured review and meta-analysis we explore the published literature on commonly recognized pathways for ...

Rapporten beskriver ideene bak, og gjennomføringen av et faglig utviklingsprosjekt, kalt ”Læring i arbeid” (LIA-prosjektet). Prosjektperioden varte fra august 2003, og ble avsluttet med en konferanse 8. februar 2005. LIA-prosjektet har vært et samarbeidsprosjekt mellom Undervisningssykehjemmet i Tromsø, Høgskolen i Tromsø og fem sykehjem i Nord-Norge.