Blar i utgivelsesdato Doktorgradsavhandlinger (Helsefak)
Viser treff 61-80 av 697
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Retro-trochanteric sciatica-like pain : in-depth analyses of clinical symptoms, treatment options, histological and ultra structural findings in tendon biopsies
(Doctoral thesis; Doktorgradsavhandling, 2010-05-28)I vår praksis ved sykehuset møtte vi stadig pasienter med uforklarlige smerter i hofte og lår, og utstråling til legg. Siden en muskel (piriformis) tidligere hadde vært beskrevet å klemme mot ischiasnerven, ville vi gjøre mer systematiske studier av dette tidligere beskrevne syndromet. Ved operasjon fant vi at en annen muskel (obturatorius internus) klemte over ischiasnerven. Oppfølgningsstudier har ... -
Nursing homes as learning environments : a study of experiences and perceptions of nursing students and supervising nurses
(Doctoral thesis; Doktorgradsavhandling, 2010-06-03)Avhandlingen bygger på 12 sykepleiestudenters erfaringer og oppfatninger om sykehjem som læringsmiljø for praksisstudier i eldreomsorg, og hvordan et utvalg på 407 norske sykepleierstudenter evaluerer læringsmiljøet i sykehjem og sykehus. Videre har jeg intervjuet 11 sykepleiere om deres syn på læringsmiljøet i sykehjem. <br>Levealderen i Norge ventes å øke, og man må regne med at fremtidens ... -
Hormone therapy use, sex hormone concentrations and gene expression : The Norwegian Women and Cancer study (NOWAC)
(Doctoral thesis; Doktorgradsavhandling, 2010-08-27)I følge salgsstatistikken økte forbruket av hormontilskudd kraftig i Norge på 1990-tallet, men avtok fra 2002. Både hormontilskudd og kroppens egenproduserte kjønnshormoner er relatert til kreft hos kvinner, bl.a. brystkreft. Kreft karakteriseres ved ukontrollert celledeling som utvikles gradvis gjennom endringer i genmaterialet. Teknologisk utvikling gjør det mulig å utforske sammenhenger mellom ... -
The role of the estrogen receptor α in the medial amygdala and the ventromedial nucleus of the hypothalamus in sexual motivation, social recognition, aggression and anxiety
(Doctoral thesis; Doktorgradsavhandling, 2010-09-01)Estrogens have been shown to be implicated not only in sexual behaviors but also in several cognitive functions, social behaviors, and emotional reactions. Estrogen receptors mediate estrogen actions in the brain and the estrogen receptor α (ERα) has attracted some attention. Although the display of female sexual motivation and copulatory behaviors require estrogens, their sites of action in brain ... -
Virtual dissection of cardiac motion : what do we measure by strain and strain rate imaging?
(Doctoral thesis; Doktorgradsavhandling, 2010-09-17)Since the introduction of strain and strain rate measurements in echocardiography of the heart, many studies have demonstrated that these parameters quantify effectively and precisely regional myocardial deformation. The method allows to measure and quantify regional myocardial function. Different cardiac diseases might be detected at an earlier stage. However, there are many factors influencing ... -
Young adults and seafood : using the voice of consumers to develop new seafood product concepts aimed at increasing consumption
(Doctoral thesis; Doktorgradsavhandling, 2010-09-24)Young adults do not eat seafood frequently enough because they lack knowledge about the preparation of a quick and easy meal with seafood. One of the ways to improve this situation is to offer young adults a product which is based on their needs and helps them to eat seafood more frequently. The first survey study showed a positive association between health involvement, attitudes towards seafood ... -
Differential processing strategies in face perception
(Doctoral thesis; Doktorgradsavhandling, 2010-09-24)Faces constitute a unique object class in that they include extensive information about many aspects of human interaction, and still imply expert processing of individual subordinate-level objects. It is necessary to understand such a basic skill before progress in applied research can take place. The present thesis describes several experimental studies that investigated different basic attributes ... -
On mobile genetic elements in enterococci : adding more facets to the complexity
(Doctoral thesis; Doktorgradsavhandling, 2010-10-01)Enterokokker er en viktig bakterie i vår normale tarm-flora, men økende virulens og resistens mot antibiotika har gjort disse bakteriene til et økende sykehusrelatert problem i den vestlige verden. Spredning av virulens og resistens skjer i hovedsak via gener som er i stand til å overføres fra en resistent bakterie til en som ikke er det. Kunnskapen om enterokokkers genetikk og disse mobile genene ... -
New insights into the clearance of tissue factor pathway inhibitor (TFPI) and unfractionated heparin (UFH)
(Doctoral thesis; Doktorgradsavhandling, 2010-11-05)”Hvor mye?”, ”Hvor ofte?” og ”Hvor lenge?” er sentrale spørsmål i studier av legemidler. For å finne en optimal behandling trenger man kunnskap om et legemiddels opptak, fordeling i kroppen, og nedbryting. Øie sitt prosjekt viser at leveren spiller en nøkkelrolle i nedbrytningen av to sentrale substanser som hemmer blodlevring (antikoagulantia), heparin og tissue factor pathway inhibitor (TFPI). ... -
The development and use of a new tool for estimating individual sun induced vitamin D in epidemiological surveys
(Doctoral thesis; Doktorgradsavhandling, 2010-11-19) -
Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
(Doctoral thesis; Doktorgradsavhandling, 2010-12-03)The work is part of a larger thematic research initiative, “Airway reactions to biological particles derived from seafood”, and was initiated in 2005 after a study conducted in the Norwegian fish industry revealed increased airway symptoms in fish industry workers. The thesis investigates the ability fish and king crab trypsins have to affect airway epithelial cells and the initiation of intracellular ... -
Mental health promotion in young children : parents as a key to the identification and reduction of risk for development of disruptive behavior problems.
(Doctoral thesis; Doktorgradsavhandling, 2010-12-03)The main aim of this dissertation was threefold. First, to establish norms for a psychometric inventory used to assess behavior problems. The project presents the first Norwegian standardization of an assessment tool specifically designed to measure childhood conduct problems. Norwegian norms for the Eyberg Child Behavior Inventory (ECBI; Robinson, Eyberg, & Ross, 1980) based on data obtained ... -
Targeted MYCN suppression and its effect on miRNA in neuroblastoma
(Doctoral thesis; Doktorgradsavhandling, 2010-12-03)Neuroblastoma is the most common extra-cranial tumour disease in children, and accounts for 15% of all childhood cancer deaths. MYCN is a transcription factor and a proto-oncogene that most often initiates transcription of target genes involved in increased proliferation and inhibition of differentiation. MYCN amplified neuroblastoma represents the most aggressive form of this disease. Silencing of ... -
Liver regeneration : the impact of altered portal hemodynamics on gene expression and growth of the porcine liver
(Doctoral thesis; Doktorgradsavhandling, 2010-12-10)Previous research on liver regeneration has focused on the volume and composition of the blood perfusing the liver remnant and their relative importance in initiating the cascade of liver regeneration after partial hepatectomy. Newer studies around year 2000 indicated nitric oxide was of paramount importance due to the increased shear stress in liver sinusoids. On the basis of experimental liver ... -
Expression and activity of NADPH oxidases (NOX) and the ROS-mediated effects on γ-Glutamyltransferase (GGT) expression in cancer cells
(Doctoral thesis; Doktorgradsavhandling, 2010-12-10)Cancer cells with the ability to metastasize have also an ability to adapt and survive in new surroundings. This is connected to their ability to alter the balance between and the level of oxidants and antioxidants within the cell. To understand how cancer cells do this, a panel of cancer cells were examined with respect to genes that can affect the oxidant production. These cells had been isolated ... -
Alterations in the renal microenvironment during the development of lupus nephritis : longditudinal studies in a murine model of systemic lupus erythematosus
(Doctoral thesis; Doktorgradsavhandling, 2010-12-15)Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that predominantly affects young women. Knowledge of the processes underlying the development of autoimmunity as well as end-organ disease manifestations is limited. One of the major contributors to morbidity and mortality in SLE patients is the development of nephritis. Using a murine model of SLE we have characterized ... -
Osteoprotegerin and cardiovascular disease
(Doctoral thesis; Doktorgradsavhandling, 2010-12-16) -
Risk and protective factors associated with internalizing symptoms in Sami and non-Sami adolescents in Arctic Norway
(Doctoral thesis; Doktorgradsavhandling, 2011-01-14)This thesis examined common and culture-specific risk and protective factors for internalizing (anxiety and depression) symptoms in Sami and non-Sami adolescents. This is a cross-sectional study, and the data are from The Norwegian Arctic Adolescent Health Study which was conducted among 10th graders in junior high schools in Arctic Norway in 2003-2005. The sample consisted of 4,449 adolescents, of ... -
Indiciense and risk factors for type 2 diabetes in a general population : the Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2011-01-28)Hovedfokus for denne avhandlingen var å avklare betydningen v forskjellige risikofaktorer for type 2 diabetes i Tromsøundersøkelsen. Den baserer seg på 11 års oppfølging fra 1994 til 2005. Utvalget besto av 26093 personer (12398 menn og 13695 kvinner) som deltok i Tromsøundersøkelsen i 1994/1995. Av disse ble 7060 screenet igjen i 2001 og 10102 i 2008. Hovedfunnene i avhandlingen var; (1) I en ... -
The secretome of cartilage, chondrocytes and chondroprogenitors : Implications for cell transplantation strategies
(Doctoral thesis; Doktorgradsavhandling, 2011-02-11)Leddbrusk har dårlig eller ingen reparasjonsevne, noe som gjør leddslitasje til et alvorlig medisinsk problem hos voksne. Flere metoder har blitt utviklet for å reparere bruskskader ved å bruke kroppens egne celler og vev. Selv om resultatene er lovende, har reparert bruskvev både dårligere kvalitet og mekaniske egenskaper, sammenlignet med friskt bruskvev. For å bedre kvaliteten til reparasjonsvevet, ...