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norskDoktorgradsavhandlinger (Helsefak): Nye registreringer
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Group-based and individualized physiotherapy for persons with multiple sclerosis - A qualitative observational and interview study
(Doctoral thesis; Doktorgradsavhandling, 2019-11-11)Physiotherapy is a complex professional practice, particularly in the care for persons with multiple sclerosis (MS). Group-based organization of interventions is a common treatment approach in MS rehabilitation, regardless of limited knowledge on the nature of essential elements of such professional practices. This dissertation presents and discusses how actions and interactions affect opportunities ... -
Impact of Chronic Obstructive Respiratory Disease (COPD), respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism (VTE) and VTE-related mortality in a general population
(Doctoral thesis; Doktorgradsavhandling, 2019-11-01)<p>Venous thromboembolism (VTE) is a collective term for pulmonary embolism (PE) and deep vein thrombosis (DVT). Chronic Obstructive Pulmonary Disease (COPD) is described as a moderate risk factor for VTE, but the association has so far been scarcely examined. The aims of this thesis were to I) investigate the impact of COPD on the risk of incident VTE and the risk of mortality in COPD-patients with ... -
Cultural adaption of mental health services to the Sami. A qualitative study on the incorporation of Sami language and culture into mental health services
(Doctoral thesis; Doktorgradsavhandling, 2019-10-18)<p>The Sami people in Norway have a statutory right to receive equitable health services, adapted in accordance with Sami language and culture. However, limited research is available regarding the impact and of Sami culture and language within mental health services. <p><i>Aim - </i>The overall aim of the study was to explore, identify and describe the significance of culture and language in mental ... -
Ambiguity and professional accountability in physiotherapy practice. Acquired brain injury rehabilitation across health care levels
(Doctoral thesis; Doktorgradsavhandling, 2019-09-10)At the time of this study, the Norwegian health care system was in the middle of the implementation of the Coordination reform, initiated in 2012 due to insufficient coordination and an increase in health care service expenditure. Earlier hospital discharge and increased municipal responsibilities for rehabilitation following acquired brain injuries (ABI) challenge the traditional rehabilitation ... -
Regulation of Autophagy-related proteins: Roles of post-translational modifications
(Doctoral thesis; Doktorgradsavhandling, 2019-09-18)Autophagy is a cell renovation system that directs almost any type of cell contents for lysosomal degradation and recycling of building blocks. It is fundamental for cellular homeostasis and for determining cell fate in response to stress. Hence, understanding the regulation of autophagy-related proteins is of great importance. This study focuses on the effect of posttranslational modifications on ... -
Periodontal health in Troms County, Northern Norway. Descriptive, subject level and site-specific analyses
(Doctoral thesis; Doktorgradsavhandling, 2019-09-20)<p><i>Background/Aim - </i>Periodontal disease is one of the most prevalent diseases in the world. There is a scarcity of epidemiological studies of periodontal disease in Norway. The overall aim of this thesis was to assess the burden of periodontitis in an adult population, and to explore risk factors, as well as health-promoting factors related to the disease. <p><i>Methods - </i>The thesis is ... -
Providing an indicated preventive intervention for children with symptoms of anxiety and depression: A study of effectiveness, implementation factors, and program fidelity
(Doctoral thesis; Doktorgradsavhandling, 2019-09-12)<p><i>Background - </i>Anxiety and depression are the most prevalent disorders among children and adolescents, and the consequences could be life damaging if these problems are ignored. However, implementing psychosocial interventions in real-life settings to prevent these issues is challenging and complex procedure. The main goals of this thesis were to investigate the effectiveness of the EMOTION: ... -
Mortality, substance use disorder and cardiovascular health care in persons with severe mental illness
(Doctoral thesis; Doktorgradsavhandling, 2019-10-04)<p><i>Background and aims - </i>In the Nordic countries, people with severe mental illness die 15-20 years younger than others. Substance use and higher level of undiagnosed/untreated somatic diseases contribute to this disparity. We aimed to investigate; (i) mortality among people with schizophrenia and/or substance use disorder, with emphasis on the impact of a dual diagnosis; (ii) whether people ... -
Biomarkers Discovery: The Benefit of the Study Exosomes Originated from Merkel Cell Carcinoma Cell Lines
(Doctoral thesis; Doktorgradsavhandling, 2019-08-30)Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine form of skin cancer with a rising incidence and a high mortality rate. The risk of developing Merkel cell carcinoma increased among a large number of immunosuppressed patients. The origin of cancer not known and the pathogenesis of MCC not fully understood. Two causes can initiate MCC tumorigenesis, such as accumulation of UV-induced ... -
Young children with problem behaviour in school settings: Evaluation of the Incredible Years Teacher Classroom Management program in a Norwegian regular school setting
(Doctoral thesis; Doktorgradsavhandling, 2019-08-30)<i>Background</i>: Children in schools, who struggle behaviourally, socially, or emotionally, are less likely to benefit from academic instruction. In regular school settings, where a large numbers of students can be reached, teachers are important and natural implementers with the potential to influence mental health outcomes in all students. Examining the impact of the Incredible Years Teacher ... -
Estrogenic modulation of socio-sexual and fear-related behaviors in female rats: Properties of the estrogen receptors α and β in a procedure with external validity
(Doctoral thesis; Doktorgradsavhandling, 2019-06-06)A number of psychiatric troubles are distributed along a biased sex ratio. Differences in sex steroids levels, notably estradiol, could account for this bias. Differential expression and activation of the two known estrogen receptors (ER), α and β could result in different behavioral patterns. Indeed, these two receptors play an important, but unequal, role in the regulation of socio-sexual and ... -
A novel risk classification system for preconception health and sero-epidemiological map of Toxoplasma, Rubella and Cytomegalovirus infections among couples planning a pregnancy in rural China: A nationwide study
(Doctoral thesis; Doktorgradsavhandling, 2019-08-30)<i>Objectives</i> - The aim of this thesis was to evaluate the feasibility, effectiveness and impact of preconception health screening strategy and a novel risk classification system of China`s “National Preconception Health Care Project (NPHCP)” in identifying risk factors and stratifying couples’ preconception care (PCC), and to establish a sero-epidemiological map of TORC infections in the ... -
Life after war-related extremity amputations. A retrospective, descriptive clinical follow-up study from Gaza, occupied Palestine
(Doctoral thesis; Doktorgradsavhandling, 2019-08-23)Little is known about medical consequences of losing arm(s) or leg(s) in military attacks. Many Palestinians in Gaza have suffered loss of one or more limbs during recurrent Israeli military incursions. Such serious physical trauma pose grave health problems not only for the amputee, but also for their families and for the society at large. The problem is increasing. Hanne Heszlein-Lossius, MD, ... -
The proteome of ulcerative colitis - Functional analyses of the active disease and the remission state in comparison with healthy controls
(Doctoral thesis; Doktorgradsavhandling, 2019-06-18)This work characterizes the proteome of human colon mucosa in ulcerative colitis (UC). We developed an optimized sample preparation method of colon mucosa biopsies for bottom-up proteomics and applied it to characterize the proteomes of active UC, remission from UC, and healthy controls. Abundances of proteins related to the immune system and to protein processing in the endoplasmic reticulum ... -
Breast cancer-associated NEAT1 in cellular stress response pathways
(Doctoral thesis; Doktorgradsavhandling, 2019-06-13)In this thesis, we investigated the role of NEAT1 in stress, cancer, and autophagy in breast cancer. In paper I, we studied NEAT1 in oxidative stress and heat shock. In the heat shock response, HSF1 translocates into the nucleus in order to activate its target gene, and we discovered a novel binding site for HSF1 in the promoter of NEAT1. The expression of NEAT1, as well as paraspeckle formation, ... -
Long-term exercise maintenance via telerehabilitation for people with COPD. Feasibility, effectiveness, benefits and challenges
(Doctoral thesis; Doktorgradsavhandling, 2019-06-06)Background and aims: The availability of pulmonary rehabilitation (PR) and exercise maintenance programs for people with chronic obstructive pulmonary disease (COPD) is low, despite being beneficial and recommended. Telerehabilitation can support the delivery of such programs to patients’ homes. However, there is little knowledge of its benefits for people with COPD. This thesis aimed to investigate ... -
Chronic hepatitis C: Epidemiology, viral resistance, and public health implications
(Doctoral thesis; Doktorgradsavhandling, 2019-06-14)Chronic hepatitis C: Epidemiology, viral resistance, and public health implications Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. The total number of HCV infections is projected to remain stable or to decline, but the ... -
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population
(Doctoral thesis; Doktorgradsavhandling, 2019-06-11)Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, elevated triglycerides and lowered high-density lipoprotein cholesterol levels. Both obesity and the ... -
Drug resistance and the functional role of microRNAs in neuroblastoma
(Doctoral thesis; Doktorgradsavhandling, 2019-06-13)Neuroblastoma is the most common solid tumor in infants. Most of the children diagnosed above one year of age, shows metastatic disease and poor prognosis. Chemotherapy is one of the principle mode of treatment. However, resistance to drug represent a major clinical obstacle for the effective treatment of cancer. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression, ... -
Too much medicine? A study investigating unwarranted regional variation and use of medical care
(Doctoral thesis; Doktorgradsavhandling, 2019-07-03)<p>Den overordna tematikken i avhandlingen er overforbruk og regional skeivbruk av helsetjenester. Fellesnevneren for delstudiene er manglende evidens for dagens praksis eller at dagens praksis ikke følger vitenskapelige anbefalinger. <p>Målet med avhandlingen var å: 1) Undersøke behandlingsmessig konsekvens av elektiv CT for pasienter med selvbegrensede anfall av mistenkt urolithiasis. 2) Kartlegge ...
