Browsing Artikler, rapporter og annet (medisinsk biologi) by Title

Now showing items 141-160 of 1054

    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study 

      Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Lee, Todd C.; Bassi, Gianluigi Li; Revilla, Jose Wagner Lopez; Marquis, Catherine; Millar, Jonathan; Neto, Raul; Nichol, Alistair; Parke, Rachael; Pereira, Rui; Poli, Sergio; Povoa, Pedro; Ramanathan, Kollengode; Rewa, Oleksa; Riera, Jordi; Shrapnel, Sally; Silva, Maria Joao; Udy, Andrew; Uyeki, Timothy; Webb, Steve A.; Wils, Evert-Jan; Rojek, Amanda; Olliaro, Piero L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
      Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, ...

    • Clinical essentialising : a qualitative study of doctors' medical and moral practice 

      Agledahl, Kari Milch; Wifstad, Åge; Førde, Reidun (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Clinical Gaze in Risk-Factor Haze: Swedish GPs' Perceptions of Prescribing Cardiovascular Preventive Drugs 

      Hultberg, Josabeth; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      To explore general practitioners’ (GPs’) descriptions of their thoughts and action when prescribing cardiovascular preventive drugs. Methods. Qualitative content analysis of transcribed group interviews with 14 participants from two primary health care centres in the southeast of Sweden. Results. GPs’ prescribing of cardiovascular preventive drugs, from their own descriptions, involved “the patient ...

    • Clinical influences on antibiotic prescribing decisions for lower respiratory tract infection: a nine country qualitative study of variation in care. 

      Brookes-Howell, Lucy; Hood, Kerenza; Cooper, Lucy; Coenen, Samuel; Little, Paul; Verheij, Theo; Godycki-Cwirko, Maciek; Melbye, Hasse; Krawzyk, Jarek; Borras-Santos, A; Jakobsen, Kristin Alise; Worby, P; Goossens, Herman; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      There is variation in antibiotic prescribing for lower respiratory tract infections (LRTI) in primary care that does not benefit patients. This study aims to investigate clinicians' accounts of clinical influences on antibiotic prescribing decisions for LRTI to better understand variation and identify opportunities for improvement. Multi country qualitative interview study. Semi-structured interviews ...

    • Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study 

      Compagno, Michele; Rekvig, Ole Petter; Bengtsson, Anders; Sturfeld, Gunnar; Heegaard, Niels H. H.; Jönsen, Andreas; Jacobsen, Rasmus S.; Eilertsen, Gro Østli; Fenton, Christopher Graham; Truedsson, Lennart; Nossent, Johannes C; Jacobsen, Søren (Journal article; Tidsskriftartikkel, 2014)

    • Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study 

      Rikardsen, Oddveig G; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Cluster of linezolid-resistant Enterococcus faecium ST117 in Norwegian hospitals 

      Hegstad, Kristin; Longva, Jørn-Åge; Hide, Reidar; Aasnæs, Bettina; Lunde, Tracy Tamara Munthali; Simonsen, Gunnar Skov (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-19)
      A linezolid-resistant, vancomycin-susceptible Enterococcus faecium strain was isolated from 3 patients who had not received linezolid. The first patient was hospitalized in the same hospitals and wards as the 2 following patients. The E. faecium isolates were resistant to linezolid (minimum inhibitory concentration 8–32 mg/l), ampicillin, and high levels of gentamicin. Resistance to linezolid was ...

    • Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway 

      Andersen, Fred; Viitanen, Matti; Halvorsen, Dag; Straume, Bjørn; Engstad, Torgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Inappropriate medical treatment of co-morbidities in Alzheimer’s disease (AD) is an increasing concern in geriatric medicine. The objective of this study was to compare current drug use related to co-morbidity between individuals with a recent diagnosis of AD and a cognitively healthy control group in a population based clinical trial in Northern Norway. Setting: Nine rural municipalities with ...

    • Cohort Profile : Cohort of Norway (CONOR) 

      Arnesen, Egil; Næss, Øyvind; Søgaard, Anne Johanne; Njølstad, Inger; Beckstrøm, Anne Cathrine; Bjertness, Espen; Engeland, Anders; Hjort, Peter F; Holmen, Jostein; Magnus, Per; Tell, Grethe S.; Vatten, Lars; Vollset, Stein Emil; Aamodt, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

    • Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study 

      Delgado, André Berli; Tylden, Eline Sol Garthsdatter; Lukic, Marko; Moi, Line Haugan; Rasmussen Busund, Lill-Tove; Lund, Eiliv; Olsen, Karina Standahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)
      Introduction - Breast cancer is the most common cancer worldwide and the leading cause of cancer related deaths among women. The high incidence and mortality of breast cancer calls for improved prevention, diagnostics, and treatment, including identification of new prognostic and predictive biomarkers for use in precision medicine.<p> <p>Material and methods - With the aim of compiling a cohort ...

    • Cohort profile: The Tromsø Study 

      Jacobsen, Bjarne Koster; Eggen, Anne Elise; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The Tromsø Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s, Norwegian men had a 20% risk of dying of myocardial infarction (MI) before the age of 75 years. The situation in Northern Norway was even worse.1 The primary aim of the Tromsø Study was to determine ...

    • A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy? 

      Dahl, Jesper; Skogen, Bjørn; Kjær, Mette; Husebekk, Anne; Kjeldsen-Kragh, Jens; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      <i>Background</i> - Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<br><br> <i>Methods and Materials</i> - We reanalyzed samples originally ...

    • A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression 

      Ghannoum, Salim; Fantini, Damiano; Zahoor, Muhammad; Reiterer, Veronika; Phuyal, Santosh; Leoncio Netto, Waldir; Sørensen, Øystein; Iyer, Arvind; Sengupta, Debarka; Prasmickaite, Lina; Mælandsmo, Gunhild Mari; Kohn Luque, Alvaro; Farhan, Hesso (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-17)
      Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing ...

    • A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer 

      Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the ...

    • Combined impact of healthy lifestyle factors on colorectal cancer: A large European cohort study 

      Aleksandrova, Krasimira; Pischon, Tobias; Jenab, Mazda; Bueno-de-Mesquita, Bas H; Fedirko, Veronika; Norat, Teresa; Romaguera, Dora; Knüppel, Sven; Boutron-Ruault, Marie-Christine; Dossus, Laure; Dartois, Laureen; Kaaks, Rudolf; Li, Kuanrong; Tjønneland, Anne; Overvad, Kim; Quirós, José Ramón; Buckland, Genevieve; Sanchez, Maria Jose; Dorronsoro, Miren; Chirlaque, Maria-Dolores; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J; Bradbury, Kathryn E; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Siersema, Peter D.; Peeters, Petra HM; Ljuslinder, Ingrid; Johansson, Ingegerd; Ericson, Ulrika; Ohlsson, Bodil; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Rinaldi, Sabina; Romieu, Isabelle; Kong, Joyce; Gunter, Marc J; Ward, Heather A; Riboli, Elio; Boeing, Heiner (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study 

      May, Anne M.; Romaguera, Dora; Travier, Noémie; Ekelund, Ulf; Bergmann, Manuela M.; Kaaks, Rudolf; Teucher, Birgit; Steffen, Annika; Boeing, Heiner; Halkjaer, Jytte; Tjonneland, Anne; Jakobsen, Marianne Uhre; Overvad, Kim; Dartois, Laureen; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Quirós, J. Ramón; Agudo, Antonio; Gonzalez, Carlos; Sanchez, Maria-José; Amiano, Pilar; Huerta, José-Maria; Ardanaz, Eva; Wareham, Nicholas J.; Crowe, Francesca L.; Naska, Androniki; Orfanos, Philippos; Trichopoulou, Antonia; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Verschuren, Monique; Drake, Isabel; Sonestedt, Emily; Braaten, Tonje; Rinaldi, Sabina; Romieu, Isabelle; Slimani, Nadia; Norat, Teresa; Riboli, Eilo; Peeters, Petra H.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The evidence that individual dietary and lifestyle factors influence a person’s weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference. We used data of the prospective EPIC-PANACEA study. ...

    • Combined Therapy With Dobutamine and Omecamtiv Mecarbil in Pigs With Ischemic Acute Heart Failure Is Attributed to the Effect of Dobutamine 

      Rødland, Lars; Rønning, Leif Reidar Brenk; Kildal, Anders Benjamin; Myrmel, Truls; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-23)
      Inotropic support in ischemic acute heart failure (AHF) is controversial. We tested a therapeutic principle for AHF by combining a low dose of omecamtiv mecarbil (OM; 0.25 mg/kg bolus plus 0.25 mg/kg/h) with a low dose of dobutamine (Dobut; 1.25 µg/kg/min). In 10 pigs subjected to myocardial ischemia by left coronary microembolization, this cotreatment increased cardiac power (CP) from 0.48 ± 0.14 ...

    • Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model 

      Camilio, Ketil Andre; Wang, Meng-Yu; Mauseth, Brynjar; Waagene, Stein; Kvalheim, Gunnar; Rekdal, Øystein; Sveinbjørnsson, Baldur; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
      <i>Background</i> - Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable ...

    • Comparative analysis of Vibrio cholerae isolates from Ghana reveals variations in genome architecture and adaptation of outbreak and environmental strains 

      Adade, Nana Eghele; Aniweh, Yaw; Mosi, Lydia; Valvano, Miguel A.; Duodu, Samuel; Ahator, Stephen Dela (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-13)
      Recurrent epidemics of cholera denote robust adaptive mechanisms of Vibrio cholerae for ecological shifting and persistence despite variable stress conditions. Tracking the evolution of pathobiological traits requires comparative genomic studies of isolates from endemic areas. Here, we investigated the genetic differentiation among V. cholerae clinical and environmental isolates by highlighting the ...

    • Comparative effectiveness of antihypertensive medication of primary prevention of cardiovascular disease : systematic review and multiple treatments meta-analysis 

      Fretheim, Atle; Odgaard-Jensen, Jan; Brørs, Odd; Madsen, Steinar; Njølstad, Inger; Norheim, Ole Frithjof; Svilaas, Arne B; Thürmer, Hanne; Flottorp, Signe (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We conducted a systematic review of evidence from randomized controlled trials to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducing the incidence of cardiovascular disease outcomes for healthy people at risk of cardiovascular disease? We searched MEDLINE, EMBASE, AMED (up to February 2011) and CENTRAL (up to May 2009), ...