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norskBlar i tittel Artikler, rapporter og annet (medisinsk biologi)
Viser treff 248-267 av 1054
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The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the ... -
A DNA-Free Editing Platform for Genetic Screens in Soybean via CRISPR/Cas9 Ribonucleoprotein Delivery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)CRISPR/Cas9-based ribonucleoprotein (RNP)-mediated system has the property of minimizing the effects related to the unwanted introduction of vector DNA and random integration of recombinant DNA. Here, we describe a platform based on the direct delivery of Cas9 RNPs to soybean protoplasts for genetic screens in knockout gene-edited soybean lines without the transfection of DNA vectors. The platform ... -
Do cancer patients with a poor prognosis use Complementary and Alternative Medicine more often than others?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009)Introduction: One reason for patients with cancer to use complementary and alternative medicine (CAM) is that their cancer cannot be cured by conventional therapy. The aim of the present study is to explore whether use of CAM is associated with survival prognosis in long-term survivors of cancer. Materials and methods: Cancer patients who were alive 5 years or more after diagnosis were chosen to ... -
Do Malawian women critically assess the quality of care? A qualitative study on women’s perceptions of perinatal care at a district hospital in Malawi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Malawi has a high perinatal mortality rate of 40 deaths per 1,000 births. To promote neonatal health, the Government of Malawi has identified essential health care packages for improving maternal and neonatal health in health care facilities. However, regardless of the availability of health services, women’s perceptions of the care is important as it influences whether the women will or will not ... -
Do not be fooled by fancy mutations: inflammatory fibroid polyps can be harbor mutations similar to those found in GIST
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Goal. Surgeons that remove a typical polyp from the stomach or small intestine should be reluctant to accept a diagnosis of GIST just because there is a mutation in platelet-derived growth factor receptor alfa (PDGFRA). Background. A subtype of gastric and intestinal polyps is denoted as inflammatory fibroid polyp (IFP). In some of these cases a mutation in PDGFRA is found, leading to the diagnosis ... -
Doctors are to blame for perceived medical adverse events. A cross sectional population study. The Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Most current knowledge of the incidence of medical adverse events (AEs) comes from studies carried out in hospital settings. Little is known about AEs occurring outside hospitals, in spite the fact that most of contacts between patients and health care take place in primary care. Small sample population studies report that 4–49% of the general public have experienced AEs related to their own or ... -
Does an activity based remuneration system attract young doctors to general practice?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The use of increasingly complex payment schemes in primary care may represent a barrier to recruiting general practitioners (GP). The existing Norwegian remuneration system is fully activity based - 2/3 fee-for-service and 1/3 capitation. Given that the system has been designed and revised in close collaborations with the medical association, it is likely to correspond - at least to some degree - ... -
Does long-term care use within primary health care reduce hospital use among older people in Norway? A national five-year population-based observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Population ageing may threaten the sustainability of future health care systems. Strengthening primary health care, including long-term care, is one of several measures being taken to handle future health care needs and budgets. There is limited and inconsistent evidence on the effect of long-term care on hospital use. We explored the relationship between the total use of long-term care within public ... -
DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in ... -
Driftsrapport 2018 - Norsk overvåkingssystem for antibiotikaresistens hos mikrober NORM
(Research report; Forskningsrapport, 2019)Driftsrapporten er en standardisert rapport som gir grunnlag for en samlet oversikt over driften av helseregistrene Folkehelseinstituttet er dataansvarlig og databehandler for. Driftsrapporten brukes også blant annet til å oppfylle enkelte av helseregistrenes forskriftsfestede meldeplikt til Datatilsynet. -
Dritbra» hvis ungdom gir oss avføringen sin
(Others; Andre, 2024-02-17)En forskningsgruppe ved UiT samler inn avføring fra barn og unge for å studere tarmbakterier. Målet er å utvikle bedre diagnoser for sykdommer og oppdage lidelser tidligere, ifølge medisinstudent Ole Martin Ellingsbø Nilsen. Prosjektet har fått økonomisk støtte fra Barnekreftforeningen og rekrutteringshjelp fra Tromsø kommune. Ungdommer som deltar får en «kit» for å samle inn prøvene, samt ... -
Drug design på data'n
(Journal article; Tidsskriftartikkel, 2013)Hva skjer i hjernen når vi føler oss glade og optimistiske? Hvorfor virker penicillin mot bakterieinfeksjoner, mens paracet virker mot hodepine? Og hvordan i all verden kan antidepressiva påvirke humøret og dermed virke mot depresjon? Svaret er molekyler. -
Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)To assess long-term virological efficacy and the emergence of drug resistance in children who receive antiretroviral treatment (ART) in rural Tanzania. Haydom Lutheran Hospital has provided ART to HIV-infected individuals since 2003. From February through May 2009, a cross-sectional virological efficacy survey was conducted among children (<15 years) who had completed ≥6 months of first-line ... -
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-24)In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC–CS NPs have high loading capacity and strong drug retention due to π–π stacking interactions between the ... -
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)Background<br> Approximately 15%–20% of all diagnosed breast cancers are characterized by amplified and overexpressed HER2 (= ErbB2). These breast cancers are aggressive and have a poor prognosis. Although improvements in treatment have been achieved after the introduction of trastuzumab and lapatinib, many patients do not benefit from these drugs. Therefore, in-depth understanding of the mechanisms ... -
Drømmen om nye tenner
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021)Tannlegene vært opptatt av muligheten for å få dannet nye tenner lenge. Det har ført til et nøye studium av den embryonale tann- dannelsen for å kunne kopiere den eksperimentelt. Forskningen har imidlertid bare i liten grad kunnet anvende sine eksperimen- telle oppsett på mennesker, men har benyttet seg av dyr som mus, rotter, minigriser og hunder, enkelte ganger i kombinasjon med in vitro ... -
Dynamic expression of VDR and 1-alpha-hydroxylase in differentiated and re-differentiated human articular chondrocytes
(Conference object; Konferansebidrag, 2016-09)<p><i>Purpose:</i> The goal was to investigate potential roles played by vitamin D in the regulation of joint cartilage biology. We studied the expression of two central elements of vitamin D metabolism, namely the vitamin D receptor and its converting enzyme 1αhydroxylase in human knee cartilage and chondrocytes. <p><i>Methods and Materials:</i> Expression of receptor and enzyme was determined ... -
Dynamic features of human mitochondrial DNA maintenance and transcription
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-07)Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different proteins of the respiratory chain complexes and an estimated 1,200 mitochondrial proteins. MtDNA is, however, crucial for organismal development, ... -
Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)ADP-ribosylation is a posttranslational modification catalyzed in cells by ADP-ribosyltransferases (ARTD or PARP enzymes). The ARTD family consists of 17 members. Some ARTDs modify their substrates by adding ADP-ribose in an iterative process, thereby synthesizing ADP-ribose polymers, the best-studied example being ARTD1/PARP1. Other ARTDs appear to mono-ADP-ribosylate their substrates and are unable ... -
Dynamics of SARS-CoV-2 Spike-IgG throughout Three COVID-19 Vaccination Regimens: A 21-Month Longitudinal Study of 82 Norwegian Healthcare Workers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)To facilitate interpretation of clinical SARS-CoV-2 anti-spike IgG analyses post-vaccination, 82 healthcare workers were followed through three vaccination-regimens: two regimens were comprised of two doses of BNT162b2 three or six weeks apart, followed by a dose of mRNA-vaccine, and in the other regimen, the first dose was replaced by ChAdOx1 nCov-19. After each dose, anti-spike IgG was compared ...
