Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

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    • Offshore telementored ultrasound: a quality assessment study 

      Vatsvåg, Victoria; Todnem, Kjetil; Næsheim, Torvind; Cathcart, John; Kerr, Daniel; Oveland, Nils Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)
      <p><i>Background - </i>Telementored ultrasound (US) connects experts to novices through various types of communication and network technologies with the overall aim to bridge the medical imaging gap between patients’ diagnostic needs and on-site user experience. The recurrent theme in previous research on remote telementored US is the limited access to US machines and experienced users. This study ...

    • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

      Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
      <p><i>Background - </i>The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic triple negative breast cancer (TNBC) wild type for BRCA1/2, we hypothesized that PARPi may be effective in primary TNBCs without previous chemotherapy exposure. < ...

    • Old tools revisited give hope - new treatment option for families with a history of severe FNAIT complications. 

      Tiller, Heidi; Fedorcsák, Péter; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-14)

    • Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals 

      Zhou, Heng; Mondragón, Laura; Xie, Wei; Mauseth, Brynjar; Leduc, Marion; Sauvat, Allan; Gomes-da-Silva, Lígia C.; Forveille, Sabrina; Iribarren, Kristina; Souquere, Sylvie; Bezu, Lucillia; Liu, Peng; Zhao, Liwei; Zitvogel, Laurence; Sveinbjørnsson, Baldur; Eksteen, Jacobus Johannes; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-23)
      Abstract Oncolytic peptides and peptidomimetics are being optimized for the treatment of cancer by selecting agents with high cytotoxic potential to kill a maximum of tumor cells as well as the capacity to trigger anticancer immune responses and hence to achieve long-term effects beyond therapeutic discontinuation. Here, we report on the characterization of two novel oncolytic peptides, DTT-205 ...

    • Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model 

      Nestvold, Janne M.; Wang, Mengyu; Camilio, Ketil Andre; Zinöcker, Severin; Tjelle, Torunn Elisabeth; Lindberg, Alf; Haug, Bengt Erik; Kvalheim, Gunnar; Sveinbjørnsson, Baldur; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
      LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant infiltration ...

    • The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells 

      Eike, Liv-Marie; Yang, Nannan; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-13)
      Host defense peptides (HDPs) are naturally occurring molecules found in most species, in which they play a significant role in the first line defense against intruding pathogens, and several HDPs have been shown to possess anticancer activity. Structure-activity relationship studies on the HDP bovine lactoferricin revealed a de novo design of a nonamer peptide LTX-315, with oncolytic properties. In ...

    • The oncolytic peptide LTX-315 triggers immunogenic cell death 

      Zhou, Heng; Forveille, Sabrina; Sauvat, Allan; Yamazaki, T; Senovilla, L; Ma, Y; Liu, Peng; Yang, H; Bezu, L; Müller, K; Zitvogel, Laurence; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-10)
      LTX-315 is a cationic amphilytic peptide that preferentially permeabilizes mitochondrial membranes, thereby causing partially BAX/ BAK1-regulated, caspase-independent necrosis. Based on the observation that intratumorally injected LTX-315 stimulates a strong T lymphocyte-mediated anticancer immune response, we investigated whether LTX-315 may elicit the hallmarks of immunogenic cell death (ICD), ...

    • Oppdatert risikovurdering – introduksjon av høypatogent aviært influensavirus til Norge våren 2007 

      Alexander, Jan; Farstad, Wenche Kristin; Haugen, Margaretha; Krogdahl, Åshild; Lie, Øyvind; Næss, Bjørn; Sundheim, Leif; Rimstad, Espen; Dybing, Erik; Nes, Ingolf; Skåre, Janneche Utne; Haldorsen, Anne-Kathrine Lundeby; Narvhus, Judith; Kapperud, Georg; Andersen, Lene Frost; Folgerø, Beate Furuto (Research report; Forskningsrapport, 2007-02-15)
      VKM ga i 2006 to risikovurderinger vedrørende introduksjon av høypatogent aviært influensavirus til Norge. Den foreliggende vurderingen er en oppdatering av disse vurderingene og besvarer spørsmål om risiko i ulike situasjoner i Norge våren 2007.

    • Opportunities and Challenges for Nanotherapeutics for the Aging Population 

      Hunt, Nicholas J; McCourt, Peter Anthony; Kuncic, Zdenka; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Nanotherapeutics utilize the properties of nanomaterials to alter the pharmacology of the drugs and therapies being transported, leading to changes in their biological disposition (absorption, distribution, cellular uptake, metabolism and elimination) and ultimately, their pharmacological effect. This provides an opportunity to optimize the pharmacology of drugs, particularly for those that are ...

    • Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure 

      Rønning, Leif; Bakkehaug, Jens P.; Rødland, Lars; Kildal, Anders B.; Myrmel, Truls; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-11)
      Acute ischemic cardiogenic shock is associated with poor prognosis, and the impact of inotropic support on diastolic function in this context is unclear. We assessed two suggested new inotropic strategies in a clinically relevant pig model of ischemic acute heart failure (AHF): treatment with the myosin activator omecamtiv mecarbil (OM) or dobutamine and ivabradine (D+I). Left ventricular (LV) ...

    • Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study 

      Kumar, Rajesh; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Biomolecular changes in the cartilage matrix during the early stage of osteoarthritis may be detected by Raman spectroscopy. The objective of this investigation was to determine vibrational spectral differences among different grades (grades I, II, and III) of osteoarthritis in human osteoarthritic cartilage, which was classified according to the International Cartilage Repair Society (ICRS) grading ...

    • Optimal starting point for antiretroviral HIV treatment in a town in Cameroon: a randomised controlled study 

      Holtedahl, Knut A.; Salpou, Daniel; Braaten, Tonje; Berved, Zogoi (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Oral health and use of dental services in different stages of adulthood in Norway: a cross sectional study 

      Hadler-Olsen, Elin Synnøve; Jönsson, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-13)
      <i>Background</i> - Socioeconomic status and oral health care habits may change throughout adult life. This calls for age-stratified analyses of oral health in the adult population to uncover differences that could be of importance for organizing adequate oral health care services. The aim of the present study was to describe self-reported oral health in different age groups in a general adult ...

    • Oral health of adults in northern Norway : a pilot study 

      Adekoya, Sarah Moriye; Brustad, Magritt (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      There is a deficiency of data on oral health of adults in northern Norway, and available reports indicate poorer oral health in the north as compared with the rest of the country. The objective of this pilot study was to develop and test out tools for a larger epidemiological study of oral health among adults in northern Norway. The study was conducted in the municipalities of Nordkapp and Båtsfjord ...

    • Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study 

      Andreassen, Renate Harriet; Jönsson, Birgitta; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-30)
      Background: Both the incidence and survival rate of head and neck cancer (HNC) is increasing, making quality of life of HNC survivors an important issue.<p> <p>Methods: In this cross-sectional study we compared the oral health related quality of life (OHRQoL) of long-term HNC survivors to that of a general population cohort from the seventh survey of the Tromsø study with the Oral Impact on Daily ...

    • Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies 

      Beral, V; Hermon, C; Peto, R; Reeves, G; Brinton, L; Marchbanks, P; Negri, E; Peeters, PHM; Vessey, M; Calle, EE; Gapstur, SM; Patel, AV; Dal Maso, L; Talamini, R; Chetrit, A; Hirsh-Yechezkel, G; Lubin, F; Sadetzki, S; Allen, N; Bull, D; Callaghan, K; Crossley, B; Gaitskell, K; Goodill, A; Green, J; Key, T; Moser, K; Collins, R; Doll, R; Gonzalez, CA; Lee, N; Ory, HW; Peterson, HB; Wingo, PA; Martin, N; Pardthaisong, T; Silpisornkosol, S; Theetranont, C; Boosiri, B; Chutivongse, S; Jimakorn, P; Virutamasen, P; Wongsrichanalai, C; Tjonneland, A; Titus-Ernstoff, L; Byers, T; Rohan, T; Mosgaard, BJ; Yeates, D; Freudenheim, JL; Chang-Claude, J; Kaaks, R; Anderson, KE; Folsom, A; Robien, K; Rossing, MA; Thomas, DB; Weiss, NS; Riboli, E; Clavel-Chapelon, F; Cramer, D; Hankinson, SE; Tworoger, SS; Franceschi, S; La Vecchia, C; Magnusson, C; Riman, T; Weiderpass, Elisabete; Wolk, A; Schouten, LJ; van den Brandt, PA; Chantarakul, N; Koetsawang, S; Rachawat, D; Palli, D; Black, A; de Gonzalez, AB; Freedman, DM; Hartge, P; Hsing, AW; Lacey, JV; Hoover, RN; Schairer, C; Graff-Iversen, Sidsel; Selmer, Randi; Bain, CJ; Green, AC; Purdie, DM; Siskind, V; Webb, PM; McCann, SE; Hannaford, P; Kay, C; Binns, CW; Lee, AH; Zhang, M; Ness, RB; Nasca, P; Coogan, PF; Palmer, JR; Rosenberg, L; Kelsey, J; Paffenbarger, R; Whittemore, A; Katsouyanni, K; Trichopoulou, A; Trichopoulos, D; Tzonou, A; Dabancens, A; Martinez, L; Molina, R; Salas, O; Goodman, MT; Lurie, G; Carney, ME; Wilkens, LR; Hartman, L; Manjer, J; Olsson, H; Grisso, JA; Morgan, M; Wheeler, JE; Casagrande, J; Pike, MC; Ross, RK; Wu, AH; Miller, AB; Kumle, Merethe; Lund, Eiliv; McGowan, L; Shu, XO; Zheng, W; Farley, TMM; Holck, S; Meirik, O; Risch, HA (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Individual data on 25,157 women with ovarian cancer and 81,311 women ...

    • Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies 

      Gaitskell, K; Hermon, C; Moser, K; Reeves, G; Peto, R; Brinton, L; Marchbanks, P; Negri, E; Ness, R; Peeters, PHM; Vessey, M; Calle, EE; Gapstur, SM; Patel, AV; Dal Maso, L; Talamini, R; Chetrit, A; Hirsh-Yechezkel, G; Lubin, F; Sadetzki, S; Banks, E; Beral, V; Bull, D; Callaghan, K; Crossley, B; Goodill, A; Green, J; Key, T; Sitas, F; Collins, R; Doll, R; Gonzalez, A; Lee, N; Ory, HW; Peterson, HB; Wingo, PA; Martin, N; Pardthaisong, T; Silpisornkosol, S; Theetranont, C; Boosiri, B; Chutivongse, S; Jimakorn, P; Virutamasen, P; Wongsrichanalai, C; Tjonneland, A; Titus-Ernstoff, L; Byers, T; Rohan, T; Mosgaard, BJ; Yeates, D; Freudenheim, JL; Chang-Claude, J; Kaaks, R; Anderson, KE; Folsom, A; Robien, K; Hampton, J; Newcomb, PA; Rossing, MA; Thomas, DB; Weiss, NS; Riboli, E; Clavel-Chapelon, F; Cramer, D; Hankinson, SE; Tworoger, SS; Franceschi, S; La Vecchia, C; Adami, HO; Magnusson, C; Riman, T; Weiderpass, Elisabete; Wolk, A; Schouten, LJ; van den Brandt, PA; Chantarakul, N; Koetsawang, S; Rachawat, D; Palli, D; Black, A; Brinton, LA; Freedman, DM; Hartge, P; Hsing, AW; Lacey, JV; Hoover, RN; Schairer, C; Urban, M; Graff-Iversen, Sidsel; Selmer, Randi; Bain, CJ; Green, AC; Purdie, DM; Siskind, V; Webb, PM; Moysich, K; McCann, SE; Hannaford, P; Kay, C; Binns, CW; Lee, AH; Zhang, M; Ness, RB; Nasca, P; Coogan, PF; Palmer, JR; Rosenberg, L; Kelsey, J; Paffenbarger, R; Whittemore, A; Katsouyanni, K; Trichopoulou, A; Trichopoulos, D; Tzonou, A; Dabancens, A; Martinez, L; Molina, R; Salas, O; Goodman, MT; Lurie, G; Carney, ME; Wilkens, LR; Hartman, L; Manjer, J; Olsson, H; Grisso, JA; Morgan, M; Wheeler, JE; Bunker, CH; Edwards, RP; Modugno, F; Casagrande, J; Pike, MC; Ross, RK; Wu, AH; Miller, AB; Kumle, Merethe; Gram, Inger Torhild; Lund, Eiliv; McGowan, L; Shu, XO; Zheng, W; Farley, TMM; Holck, S; Meirik, O; Risch, HA (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence. Eligible epidemiological studies were identified by electronic searches, review articles, and discussions ...

    • Overdiagnosis of breast cancer in the Norwegian Breast Cancer Screening Program estimated by the Norwegian Women and Cancer cohort study 

      Lund, Eiliv; Mode, Nicolle; Waaseth, Marit; Thalabard, Jean-Christophe (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifetime outside screening. This analysis compares the cumulative incidence of breast cancer in screened and unscreened women in Norway from the start of the fully implemented Norwegian ...

    • Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling 

      Hansen, Synne; Pedersen, Tina Myhre; Marin, Julie; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)
      The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte specific upregulation of NOX2 (csNOX2 TG). Mice were treated with saline (sham), 50 or 400 ng/kg/min of AngII (AngII50 and AngII400) for two weeks. In ...

    • Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study 

      Norvik, Jon Viljar; Storhaug, Hilde-Merete; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ...