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dc.contributor.authorRandall, JC
dc.contributor.authorWinkler, TW
dc.contributor.authorKutalik, Z
dc.contributor.authorBerndt, SI
dc.contributor.authorJackson, AU
dc.contributor.authorMonda, KL
dc.contributor.authorKilpelainen, TO
dc.contributor.authorEsko, T
dc.contributor.authorMagi, R
dc.contributor.authorLi, SX
dc.contributor.authorWorkalemahu, T
dc.contributor.authorFeitosa, MF
dc.contributor.authorCroteau-Chonka, DC
dc.contributor.authorDay, FR
dc.contributor.authorFall, T
dc.contributor.authorFerreira, T
dc.contributor.authorGustafsson, S
dc.contributor.authorLocke, AE
dc.contributor.authorMathieson, I
dc.contributor.authorScherag, A
dc.contributor.authorVedantam, S
dc.contributor.authorWood, AR
dc.contributor.authorLiang, LM
dc.contributor.authorSteinthorsdottir, V
dc.contributor.authorThorleifsson, G
dc.contributor.authorDermitzakis, ET
dc.contributor.authorDimas, AS
dc.contributor.authorKarpe, F
dc.contributor.authorMin, JL
dc.contributor.authorNicholson, G
dc.contributor.authorClegg, DJ
dc.contributor.authorPerson, T
dc.contributor.authorKrohn, JP
dc.contributor.authorBauer, S
dc.contributor.authorBuechler, C
dc.contributor.authorEisinger, K
dc.contributor.authorBonnefond, A
dc.contributor.authorFroguel, P
dc.contributor.authorHottenga, JJ
dc.contributor.authorProkopenko, I
dc.contributor.authorWaite, LL
dc.contributor.authorHarris, TB
dc.contributor.authorSmith, AV
dc.contributor.authorShuldiner, AR
dc.contributor.authorMcArdle, WL
dc.contributor.authorCaulfield, MJ
dc.contributor.authorMunroe, PB
dc.contributor.authorGronberg, H
dc.contributor.authorChen, YDI
dc.contributor.authorLi, G
dc.contributor.authorBeckmann, JS
dc.contributor.authorJohnson, T
dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorTeder-Laving, M
dc.contributor.authorKhaw, KT
dc.contributor.authorWareham, NJ
dc.contributor.authorZhao, JH
dc.contributor.authorAmin, N
dc.contributor.authorOostra, BA
dc.contributor.authorKraja, AT
dc.contributor.authorProvince, MA
dc.contributor.authorCupples, LA
dc.contributor.authorHeard-Costa, NL
dc.contributor.authorKaprio, J
dc.contributor.authorRipatti, S
dc.contributor.authorSurakka, I
dc.contributor.authorCollins, FS
dc.contributor.authorSaramies, J
dc.contributor.authorTuomilehto, J
dc.contributor.authorJula, A
dc.contributor.authorSalomaa, V
dc.contributor.authorErdmann, J
dc.contributor.authorHengstenberg, C
dc.contributor.authorLoley, C
dc.contributor.authorSchunkert, H
dc.contributor.authorLamina, C
dc.contributor.authorWichmann, HE
dc.contributor.authorAlbrecht, E
dc.contributor.authorGieger, C
dc.contributor.authorHicks, AA
dc.contributor.authorJohansson, A
dc.contributor.authorPramstaller, PP
dc.contributor.authorKathiresan, S
dc.contributor.authorSpeliotes, EK
dc.contributor.authorPenninx, B
dc.contributor.authorHartikainen, AL
dc.contributor.authorJarvelin, MR
dc.contributor.authorGyllensten, U
dc.contributor.authorBoomsma, DI
dc.contributor.authorCampbell, H
dc.contributor.authorWilson, JF
dc.contributor.authorChanock, SJ
dc.contributor.authorFarrall, M
dc.contributor.authorGoel, A
dc.contributor.authorMedina-Gomez, C
dc.contributor.authorRivadeneira, F
dc.contributor.authorEstrada, K
dc.contributor.authorUitterlinden, AG
dc.contributor.authorHofman, A
dc.contributor.authorZillikens, MC
dc.contributor.authorden Heijer, M
dc.contributor.authorKiemeney, LA
dc.contributor.authorMaschio, A
dc.contributor.authorHall, P
dc.contributor.authorTyrer, J
dc.contributor.authorTeumer, A
dc.contributor.authorVolzke, H
dc.contributor.authorKovacs, P
dc.contributor.authorTonjes, A
dc.contributor.authorMangino, M
dc.contributor.authorSpector, TD
dc.contributor.authorHayward, C
dc.contributor.authorRudan, I
dc.contributor.authorHall, AS
dc.contributor.authorSamani, NJ
dc.contributor.authorAttwood, AP
dc.contributor.authorSambrook, JG
dc.contributor.authorHung, J
dc.contributor.authorPalmer, LJ
dc.contributor.authorLokki, ML
dc.contributor.authorSinisalo, J
dc.contributor.authorBoucher, G
dc.contributor.authorHuikuri, H
dc.contributor.authorLorentzon, M
dc.contributor.authorOhlsson, C
dc.contributor.authorEklund, N
dc.contributor.authorEriksson, JG
dc.contributor.authorBarlassina, C
dc.contributor.authorRivolta, C
dc.contributor.authorNolte, IM
dc.contributor.authorSnieder, H
dc.contributor.authorVan der Klauw, MM
dc.contributor.authorVan Vliet-Ostaptchouk, JV
dc.contributor.authorGejman, PV
dc.contributor.authorShi, JX
dc.contributor.authorJacobs, KB
dc.contributor.authorWang, ZM
dc.contributor.authorBakker, SJL
dc.contributor.authorLeach, IM
dc.contributor.authorNavis, G
dc.contributor.authorvan der Harst, P
dc.contributor.authorMartin, NG
dc.contributor.authorMedland, SE
dc.contributor.authorMontgomery, GW
dc.contributor.authorYang, J
dc.contributor.authorChasman, DI
dc.contributor.authorRidker, PM
dc.contributor.authorRose, LM
dc.contributor.authorLehtimaki, T
dc.contributor.authorRaitakari, O
dc.contributor.authorAbsher, D
dc.contributor.authorIribarren, C
dc.contributor.authorBasart, H
dc.contributor.authorHovingh, KG
dc.contributor.authorHypponen, E
dc.contributor.authorPower, C
dc.contributor.authorAnderson, D
dc.contributor.authorBeilby, JP
dc.contributor.authorHui, JN
dc.contributor.authorJolley, J
dc.contributor.authorSager, H
dc.contributor.authorBornstein, SR
dc.contributor.authorSchwarz, PEH
dc.contributor.authorKristiansson, K
dc.contributor.authorPerola, M
dc.contributor.authorLindstrom, J
dc.contributor.authorSwift, AJ
dc.contributor.authorUusitupa, M
dc.contributor.authorAtalay, M
dc.contributor.authorLakka, TA
dc.contributor.authorRauramaa, R
dc.contributor.authorBolton, JL
dc.contributor.authorFowkes, G
dc.contributor.authorFraser, RM
dc.contributor.authorPrice, JF
dc.contributor.authorFischer, K
dc.contributor.authorKrjutAikov, K
dc.contributor.authorMetspalu, A
dc.contributor.authorMihailov, E
dc.contributor.authorLangenberg, C
dc.contributor.authorLuan, JA
dc.contributor.authorOng, KK
dc.contributor.authorChines, PS
dc.contributor.authorKeinanen-Kiukaanniemi, SM
dc.contributor.authorSaaristo, TE
dc.contributor.authorEdkins, S
dc.contributor.authorFranks, PW
dc.contributor.authorHallmans, G
dc.contributor.authorShungin, D
dc.contributor.authorMorris, AD
dc.contributor.authorPalmer, CNA
dc.contributor.authorErbel, R
dc.contributor.authorMoebus, S
dc.contributor.authorNothen, MM
dc.contributor.authorPechlivanis, S
dc.contributor.authorHveem, Kristian
dc.contributor.authorNarisu, N
dc.contributor.authorHamsten, A
dc.contributor.authorHumphries, SE
dc.contributor.authorStrawbridge, RJ
dc.contributor.authorTremoli, E
dc.contributor.authorGrallert, H
dc.contributor.authorThorand, B
dc.contributor.authorIllig, T
dc.contributor.authorKoenig, W
dc.contributor.authorMuller-Nurasyid, M
dc.contributor.authorPeters, A
dc.contributor.authorBoehm, BO
dc.contributor.authorKleber, ME
dc.contributor.authorMarz, W
dc.contributor.authorWinkelmann, BR
dc.contributor.authorKuusisto, J
dc.contributor.authorLaakso, M
dc.contributor.authorArveiler, D
dc.contributor.authorCesana, G
dc.contributor.authorKuulasmaa, K
dc.contributor.authorVirtamo, J
dc.contributor.authorYarnell, JWG
dc.contributor.authorKuh, D
dc.contributor.authorWong, A
dc.contributor.authorLind, L
dc.contributor.authorde Faire, U
dc.contributor.authorGigante, B
dc.contributor.authorMagnusson, PKE
dc.contributor.authorPedersen, NL
dc.contributor.authorDedoussis, G
dc.contributor.authorDimitriou, M
dc.contributor.authorKolovou, G
dc.contributor.authorKanoni, S
dc.contributor.authorStirrups, K
dc.contributor.authorBonnycastle, LL
dc.contributor.authorNjølstad, Inger
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorGanna, A
dc.contributor.authorRehnberg, E
dc.contributor.authorHingorani, A
dc.contributor.authorKivimaki, M
dc.contributor.authorKumari, M
dc.contributor.authorAssimes, TL
dc.contributor.authorBarroso, IS
dc.contributor.authorBoehnke, M
dc.contributor.authorBorecki, IB
dc.contributor.authorDeloukas, P
dc.contributor.authorFox, CS
dc.contributor.authorFrayling, T
dc.contributor.authorGroop, LC
dc.contributor.authorHaritunians, T
dc.contributor.authorHunter, D
dc.contributor.authorIngelsson, E
dc.contributor.authorKaplan, R
dc.contributor.authorMohlke, KL
dc.contributor.authorO'Connell, JR
dc.contributor.authorSchlessinger, D
dc.contributor.authorStrachan, DP
dc.contributor.authorStefansson, K
dc.contributor.authorvan Duijn, CM
dc.contributor.authorAbecasis, GR
dc.contributor.authorMcCarthy, MI
dc.contributor.authorHirschhorn, JN
dc.contributor.authorQi, L
dc.contributor.authorLoos, Ruth J.F.
dc.contributor.authorLindgren, CM
dc.contributor.authorNorth, KE
dc.contributor.authorHeid, IM
dc.date.accessioned2014-03-21T07:40:05Z
dc.date.available2014-03-21T07:40:05Z
dc.date.issued2013
dc.description.abstractGiven the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR,5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P,561028), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits.en
dc.identifier.citationPLoS Genetics 9(2013) nr. 6:e1003500 s. -en
dc.identifier.cristinIDFRIDAID 1073784
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pgen.1003500
dc.identifier.issn1553-7390
dc.identifier.urihttps://hdl.handle.net/10037/6039
dc.identifier.urnURN:NBN:no-uit_munin_5743
dc.language.isoengen
dc.publisherPLoSen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en
dc.titleSex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traitsen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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