Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Growing up with parental substance use disorder: The struggle with complex emotions, regulation of contact, and lack of professional support 

      Wangensteen, Turid; Bramness, Jørgen Gustav; Halsa, Astrid Dagmar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-20)
      The aim of the study was to explore young people's perceptions and reflections about growing up with parents who have substance use disorder (SUD). In qualitative inter-views with 12 young people (aged 13–26) and in an interpretative phenomenological analysis, we investigated their experiences of everyday life, of the relationships with the parents with SUD, and of conversations about this, both ...

    • Growth and neurodevelopment in very preterm infants receiving a high enteral volume-feeding regimen - a population-based cohort study 

      Klingenberg, Claus; Muraas, Fredrik Kragh; Isaksen, Catherine Elde; Nilsen, Tina; Torgersen, Marte; Melum-Hansen, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-06)
      <i>Aim</i>: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment.<p> <p><i>Method</i>: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005–2010. ...

    • Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 

      Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia; Granerud, Beathe Kiland; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Tonby, Kristian; Kildal, Anders Benjamin; Heggelund, Lars; Tveita, Anders Aune; Bøe, Simen; Müller, Karl Erik; Jenum, Synne; Hov, Johannes Espolin Roksund; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)
      Background - Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut microbiota and mortality are scarce.<p> <p>Methods - Rectal swabs for gut microbiota analyses were collected within 48 h after hospital admission (baseline; n = 123) and three-month ...

    • GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility 

      Eriksson, Daniel; Røyrvik, Ellen Christine; Aranda-Guillen, Maribel; Berger, Amund Holte; Landegren, Nils; Artaza, Haydee; Hallgren, Åsa; Grytaas, Marianne; Strøm, Sara; Bratland, Eirik; Botusan, Ileana; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Vaudel, Marc; Helgeland, Øyvind; Falorni, Alberto; Jørgensen, Anders Palmstrøm; Hulting, Anna-Lena; Svartberg, Johan; Ekwall, Olov; Fougner, Kristian J; Wahlberg, Jeanette; Nedrebø, Bjørn Gunnar; Dahlqvist, Per; Study group, Norwegian Addison Registry; Study Group, Swedish Addison Registry; Knappskog, Per Morten; Wolff, Anette Susanne Bøe; Bensing, Sophie; Johansson, Stefan; Kämpe, Olof; Husebye, Eystein Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-11)
      Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10−8). In addition to loci implicated in lymphocyte function and development shared with other ...

    • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 

      Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Corrêa, Ivan R.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir Lingaas; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Inês; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njølstad, Inger; Wichmann, H.-Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josée; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
      Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without ...

    • Hand grip strength and risk of incident venous thromboembolism: The Tromsø study 

      Leknessund, Oda; Morelli, Vania Maris; Strand, Bjørn Heine; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)
      <p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ...

    • Hand grip strength in venous thromboembolism: risk of recurrence and mortality 

      Leknessund, Oda; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ...

    • Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model 

      Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin; Lappegård, Knut Tore; How, Ole-Jakob; Nilsen, Bent Aksel; Kiss, Gabriel Hanssen; Skogvoll, Eirik; Torp, Hans; Ingul, Charlotte Ingeborg Björk (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      Background/Purpose - Pulse palpation is an unreliable method for diagnosing cardiac arrest. To address this limitation, continuous hemodynamic monitoring may be a viable solution. Therefore, we developed a novel, hands-free Doppler system, RescueDoppler, to detect the pulse continuously in the carotid artery.<p> <p>Methods - In twelve pigs, we evaluated RescueDoppleŕs potential to measure blood ...

    • Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 

      Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Background:<br> Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2 - 2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. <br>Methods:<br> In this single centre ...

    • Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain? 

      Nieder, Carsten; Marienhagen, Kirsten; Dalhaug, Astrid; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-16)
      Newly developed systemic treatment regimens might lead to improved survival also in the subgroup of breast cancer patients that harbour brain metastases. In order to examine this hypothesis, a matched pairs analysis was performed that involved one group of patients, which were treated after these new drugs were introduced, and one group of patients, which were treated approximately 10 years earlier. ...

    • Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis 

      Goll, Rasmus; Heitmann, Richard; Moe, Øystein Kittel; Katrine, Carlsen; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)
      <i>Background</i> - Fecal calprotectin is widely used to monitor disease activity in patients with inflammatory bowel disease. Multiple commercial kits exist, however, since the analyses are not standardized, these kits cannot be used interchangeably. We aimed to perform a technical evaluation of two kits (Calpro from Calprolab, Norway and Calprest from Eurospital, Italy) and perform a tuning for ...

    • Headache patients' satisfaction with telemedicine: a 12-month follow-up randomized non-inferiority trial 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      Background and purpose: We investigated non-acute headache patients’ long-term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less satisfied with telemedicine than traditional consultations. We also examined the influence of gender, age and education on satisfaction. <br> <br> Methods: For 2.5 years, patients ...

    • Healing in the Sami North 

      Sexton, Randall Harold; Stabbursvik, Ellen Anne Buljo (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Health characteristics associated with chemsex among men who have sex with men: Results from a cross-sectional clinic survey in Norway 

      Amundsen, Eirik; Haugstvedt, Åse; Skogen, Vegard; Berg, Rigmor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Background Chemsex typically involves drugs such as GHB/GBL, crystal meth and mephedrone, and is increasingly common among MSM. The behaviour has been found to be associated with sexually transmitted infections (STIs) and mental health problems. We aimed to assess the extent of chemsex engagement and associations with different aspects of health, among MSM attending a free specialist walk-in clinic ...

    • Health Economics and Radium-223 (Xofigo®) in the Treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Case History and a Systematic Review of the Literature 

      Norum, Jan; Traasdahl, Erik R.; Totth, Arpad; Nieder, Carsten; Olsen, Jan Abel (Journal article; Peer reviewed; Tidsskriftartikkel, 2015)
      OBJECTIVES: Prostate cancer (PC) is the most common cancer in Western countries. Recent advances in the treatment of metastatic castration resistant prostate cancer (mCRPC) have caused significant pressure on health care budgets. We aimed to exemplify this dilemma presenting an example, radium-223 (Xofigo®), and review the literature. METHODS: A 74-year-old man diagnosed with mCRPC was referred ...

    • Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. 

      Lorem, Geir F; Schirmer, Henrik; Emaus, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-05)
      The objective of this study was to develop a method of classifying comorbid conditions that accounts for both the severity and joint effects of the diseases. The Tromsø Study is a cohort study with a longitudinal design utilizing a survey approach with physical examinations in the Tromsø municipality from 1974 to 2008, where in total 40051 subjects participated. We used Tromsø 4 as reference population ...

    • Health information accessed on the Internet: the development in 5 European countries 

      Kummervold, Per Egil; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The aim of this study was to summarize and analyse findings from four prior studies on the use of the Internet as a source of health information in five European countries (Norway, Denmark, Germany, Greece, and Portugal). A cross-study comparison of data was performed. All the studies included fit with a trend of a sharp and continuous growth in the use of the Internet for health information access ...

    • Health Professionals' Experience with Patients Accessing Their Electronic Health Records: Results from an Online Survey 

      Johansen, Monika Alise; Kummervold, Per Egil; Sørensen, Tove; Zanaboni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      The aim of this study was to investigate hospital professionals’ experience and attitude with patients accessing their own electronic health records. The study was conducted one year after service establishment. Data was collected through an online survey. In total, 457 replies were received. The results revealed a quarter of the administrative staff received feedback from patients or relatives ...

    • Health Related Quality of life in Adolescents with Chronic Fatigue Syndrome: A Cross-sectional Study 

      Winger, Anette; Kvarstein, Gunnvald; Wyller, Vegard Bruun; Ekstedt, Mirjam; Sulheim, Dag; Fagermoen, Frode Even; Småstuen, Milada C; Helseth, Sølvi (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-03)
      Aim: To study health related quality of life (HRQOL) and depressive symptoms in adolescents with chronic fatigue syndrome (CFS) and to investigate in which domains their HRQOL and depressive symptoms differ from those of healthy adolescents. <br>Background and objective: Several symptoms such as disabling fatigue, pain and depressive symptoms affect different life domains of adolescents with ...

    • Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study 

      Søberg, Helene L.; Røe, Cecilie; Anke, Audny; Arango-Lasprilla, Juan Carlos; Skandsen, Toril; Sveen, Unni; von Steinbuchel, Nicole; Andelic, Nada (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      OBJECTIVE: To assess health-related quality of life in individuals with severe traumatic brain injury at 12 months post-injury, applying the Quality of Life after Brain Injury (QOLIBRI) instrument, and to study the relationship between injury-related factors, post-injury functioning and health-related quality of life. Design/subjects: The study is part of a prospective, Norwegian multicentre study ...