Blar i tittel Artikler, rapporter og annet (klinisk medisin)

Viser treff 113-132 av 1796

    • Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population 

      Melsom, Toralf; Norvik, Jon Viljar; Enoksen, Inger Therese; Stefansson, Vidar Tor Nyborg; Rismo, Renathe; Jenssen, Trond; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      <i>Introduction</i> - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used ...

    • Association of iron deficiency with incident cardiovascular diseases and mortality in the general population 

      Schrage, Benedict; Rübsamen, Nicole; Ojeda, Francisco; Thorand, Barbara; Peters, Annette; Koenig, Wolfgang; Söderberg, Stefan; Söderberg, Maja; Mathiesen, Ellisiv B.; Njølstad, Inger; Kee, Frank; Linneberg, Allan; Kuulasmaa, Kari; Palosaari, Tarja; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Karakas, Mahir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Aims - Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.<p> <p>Methods and results - In 12 164 individuals from three European population-based ...

    • Association of low-density lipoprotein cholesterol with risk of aortic valve stenosis in familial hypercholesterolemia 

      Mundal, Liv; Hovland, Anders; Igland, Jannicke; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven; Tell, Grethe S.; Leren, Trond Paul; Retterstøl, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)
      <i>Importance</i> - Aortic valve stenosis (AS) is the most common valve disease. Elevated levels of low-density lipoprotein (LDL) cholesterol are a risk factor; however, lipid-lowering treatment seems not to prevent progression of AS. The importance of LDL cholesterol in the development of AS thus remains unclear. People with familial hypercholesterolemia (FH) have elevated LDL cholesterol levels ...

    • Association of maternal SARS-CoV-2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study 

      Chen, An; Acharya, Ganesh Prasad; Hu, Min; Gao, Xin; Cheng, Guizhi; Jiang, Lai; Ni, Qianqian (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-05)
      Introduction - This study aimed to investigate the impact of maternal SARS-CoV-2 infection at the time of admission for delivery on labor process and outcomes of vaginal birth.<p> <p>Material and methods - A cohort study was carried out at the Obstetrics Department of Anhui Provincial Hospital, China, where universal reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 ...

    • Association of physical activity with overall mortality among long-term testicular cancer survivors: A longitudinal study 

      Thorsen, Lene; Courneya, Kerry S.; Steene-Johannessen, Jostein; Gran, Jon Michael; Haugnes, Hege Sagstuen; Negaard, Helene Francisca Stigter; Kiserud, Cecilie E.; Fosså, Sophie Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-19)
      Physical activity (PA) has been associated with reduced mortality among cancer survivors, but no study has focused on testicular cancer survivors (TCSs). We aimed to investigate the association of PA measured twice during survivorship with overall mortality in TCSs. TCSs treated during 1980 to 1994 participated in a nationwide longitudinal survey between 1998 to 2002 (S1: n = 1392) and 2007 to 2009 ...

    • Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort 

      Paulsen, Benedikte; Gran, Olga Vikhammer; Severinsen, Marianne T.; Hammerstrøm, Jens; Kristensen, Søren Risom; Cannegieter, Suzanne C.; Skille, Hanne; Tjønneland, Anne; Rosendaal, Frits; Overvad, Kim; Næss, Inger Anne; Hansen, John-Bjarne; Brækkan, Sigrid K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-21)
      Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in ...

    • Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: A systematic review and meta-analysis 

      Achten, Niek B.; Klingenberg, Claus; Benitz, William E.; Stocker, Martin; Schlapbach, Luregn J.; Giannoni, Eric; Bokelaar, Robin; Driessen, Gertjan J.A.; Brodin, Petter; Uthaya, Sabita; van Rossum, Annemarie M.C.; Plötz, Frans B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-03)
      <i>Importance</i> - The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.<p> <p><i>Objective</i> - To assess the association between management of neonatal EOS ...

    • Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study 

      Vimaleswaran, Kerani S.; Cavadino, Alana; Berry, Diane J.; Jorde, Rolf; Grimnes, Guri; Dieffenbach, Aida Karina; Lu, Chen; Alves, Alexessander Couto; Heerspink, Hiddo J. Lambers; Tikkanen, Emmi; Eriksson, Joel; Wong, Andrew; Mangino, Massimo; Jablonski, Kathleen A.; Nolte, Ilja M.; Houston, Denise K.; Ahluwalia, Tarunveer Singh; van der Most, Peter J.; Pasko, Dorota; Zgaga, Lina; Thiering, Elisabeth; Schöttker, B; Saum, KU; Brenner, H; Järvelin, MR; Tzoulaki, I; Snieder, H; Stolk, RP; Hartman, CA; de Boer, RA; van der Harst, P; Navis, G; de Borst, MH; Lorentzon, M; Mellström, D; Ohlsson, C; Hardy, R; Kuh, D; Cooper, JA; Acharya, J; Humphries, SE; Hingorani, AD; Kumari, M; Kivimaki, M; Spector, TD; Kritchevsky, SB; Lohman, KK; Sørensen, TIA; Frayling, TM; Campbell, H; Theodoratou, E; Fraser, RM; Wilson, JF; Rudan, I; Price, JF; McLachlan, S; Vitart, V; Navarro, P; Huffman, JE; Hayward, C; Wright, AF; Tiesler, CMT; Heinrich, J; McCarthy, MI; Ingelsson, E; Arden, N; Cooper, C; Dupuis, J; Herzig, KH; Sebert, S; Pouta, A; Laitinen, J; Kleber, ME; März, W; Jameson, K; Osmond, C; Raitakari, O; Ripatti, S; Lahti, J; Eriksson, JG; Penninx, BW; Billings, LK; Florez, JC; Rejnmark, L; Langdahl, BL; Paternoster, L; Hernandez, DG; Byberg, L; Michaelsson, K; Hagström, E; Melhus, H; Ljunggren, O; Lind, L; Jula, A; Polasek, O; Salomaa, V; Karlsson, M; Bandinelli, S; Lehtimäki, T; Wang, TJ; Pilz, S; Whittaker, JC (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-25)
      Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated ...

    • Associations between cervical dilatation on admission and mode of delivery, a cohort study of Norwegian nulliparous women 

      Gjærum, Ragnhild; Johansen, Ingvild; Øian, Pål; Bernitz, Stine; Dalbye, Rebecka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Objective - To investigate associations between cervical dilatation at hospital admission and mode of delivery.<p> <p>Methods - A cohort study with data from a cluster-randomised controlled trial, the Labour Progression Study. The study population of 6511 nulliparous women with a singleton fetus in cephalic presentation with spontaneous onset of labour at term, was divided into two groups: <4 cm ...

    • Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study 

      Reiseter, Silje; Molberg, Øyvind; Gunnarsson, Ragnar; Lund, May Brit; Aaløkken, Trond Mogens; Aukrust, Pål; Ueland, Thor; Garen, Torhild; Brunborg, Cathrine; Michelsen, Annika; Abraityte, Aurelija; Hoffmann-Vold, Anna-Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-28)
      Introduction: Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselected cohorts of SSc and MCTD. Methods: Sera of SSc patients (N = 298) and MCTD ...

    • Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study 

      Solomon, Terry; Smith, Erin N.; Matsui, Hiroko; Brækkan, Sigrid Kufaas; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Frazer, Kelly A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
      Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated ...

    • Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism 

      Høiland, Ina Isabella; Liang, Robin Amanda; Hindberg, Kristian; Latysheva, Nadezhda; Brekke, Ole-Lars; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-30)
      INTRODUCTION: Deep vein thrombosis (DVT) originates in the valvular sinuses of large veins in a local milieu characterized by stasis and severe hypoxia. This may induce complement- and coagulation activation, which potentially increases the risk of venous thromboembolism (VTE). The aim of the present study was to investigate whether the activity of the complement pathways, the level of mannose-binding ...

    • Associations between Multiple Accelerometry-Assessed Physical Activity Parameters and Selected Health Outcomes in Elderly People - Results from the KORA-Age Study 

      Ortlieb, Sandra; Gorzelniak, Lukas; Novak, Dennis; Strobl, Ralf; Grill, Eva; Thorand, Barbara; Peters, Annette; Kuhn, Klaus A.; Karrasch, Stefan; Horsch, Alexander; Schulz, Holger (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Associations Between the Use of eHealth and Out-of-Hours Services in People With Type 1 Diabetes: Cross-Sectional Study 

      Hansen, Anne Helen; Claudi, Tor; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
      <p><i>Background - </i>Despite the increasing prevalence of diabetes and the increasing use of eHealth, little is known about the association between provider-based health services and eHealth among people with diabetes. This is the second study in a project exploring the associations between the use of eHealth and the use of provider-based health services. <p><i>Objective - </i>The objective of ...

    • Associations of adolescent alcohol use and self-reported alcohol tolerance with risk of self-harm and suicide in early adulthood: a birth-cohort study 

      Levola, Jonna; Denisoff, Alexander; Mustonen, Antti; Alakokkare, Anni-Emilia; Miettunen, Jouko; Bramness, Jørgen Gustav; Niemelä, Solja (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Objective We aimed to assess the predictive associations of age at first drink (AFD), age at first intoxication (AFI), frequency of intoxication, and self-reported alcohol tolerance at age 15-16 to self-harm requiring medical attention or suicide death by age 33.<p> <p>Method In an ongoing follow-up study, the Northern Finland Birth Cohort 1986, a total of 7,735 individuals were included at age ...

    • Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis 

      Auensen, Andreas; Hussain, Amjad; Falk, Ragnhild Sørum; Walle-Hansen, Marte Meyer; Bye, Jorun; Pettersen, Kjell; Ueland, Thor; Gullestad, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
      Objectives:<br>Among patients with severe aortic stenosis (AS), we investigated the associations of N–terminal pro–natriuretic peptide (NT–proBNP), high–sensitive troponin T (hsTnT), and high–sensitive C–reactive protein (hs–CRP) with 3–year mortality and major adverse cardiovascular events (MACE) during 1 year.<br>Methods:<br>This observational cohort study prospectively enrolled 442 patients with ...

    • Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study 

      Uhlving Larsen, Anette; Hopstock, Laila Arnesdatter; Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-06)
      Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N).<p> <p>Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents ...

    • Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...

    • ATPase activity of DFCP1 controls selective autophagy 

      Nahse-Kumpf, Viola; Raiborg, Camilla; Tan, Kia Wee; Mørk, Sissel; Torgersen, Maria Lyngaas; Wenzel, Eva; Nager Grifo, Mireia; Salo, Veijo T.; Johansen, Terje; Ikonen, Elina; Schink, Kay Oliver; Stenmark, Harald Alfred (Journal article; Tidsskriftartikkel, 2023-07-08)
      Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ...

    • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

      Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
      <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...