Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Prognostic Impacts of Angiopoietins in NSCLC Tumor Cells and Stroma : VEGF-A Impact Is Strongly Associated with Ang-2 

      Andersen, Sigve; Dønnem, Tom; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Stenvold, Helge; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiopoietins and their receptor Tie-2 are, in concert with VEGF-A, key mediators in angiogenesis. This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A. 335 unselected stage I-IIIA NSCLC-patients were included and tissue samples of respective tumor cells and ...

    • Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma 

      Smeland, Eivind; Kilvær, Thomas Karsten; Sørbye, Sveinung Wergeland; Valkov, Andrey Yurjevich; Andersen, Sigve; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIFregulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from206 patients with non-GIST STS were obtained and tissue microarrays were constructed. ...

    • Prognostic indices for brain metastases : usefulness and challenges 

      Mehta, Minesh P.; Nieder, Carsten (Journal article; Peer reviewed; Tidsskriftartikkel, 2009-03-04)
      Background: This review addresses the strengths and weaknesses of 6 different prognostic indices, published since the Radiation Therapy Oncology Group (RTOG) developed and validated the widely used 3-tiered prognostic index known as recursive partitioning analysis (RPA) classes, i.e. between 1997 and 2008. In addition, other analyses of prognostic factors in groups of patients, which typically ...

    • A prognostic model for failure and worsening after lumbar microdiscectomy: a multicenter study from the Norwegian Registry for Spine Surgery 

      Werner, David Andreas Thomas; Grotle, Margreth; Småstuen, Milada Cvancarova; Gulati, Sasha; Nygaard, Øystein Petter; Salvesen, Øyvind; Ingebrigtsen, Tor; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-10)
      <i>Objective</i> - To develop a prognostic model for failure and worsening 1 year after surgery for lumbar disc herniation.<br><br> <i>Methods</i> - This multicenter cohort study included 11,081 patients operated with lumbar microdiscectomy, registered at the Norwegian Registry for Spine Surgery. Follow-up was 1 year. Uni- and multivariate logistic regression analyses were used to assess potential ...

    • The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas 

      Søland, Tine Merete; Solhaug, Maren Bråten; Bjerkli, Inger-Heidi; Schreurs, Olaf Joseph Franciscus; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. ...

    • The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort 

      Ness, Nora; Andersen, Sigve; Khanehkenari, Mehrdad Rakaee; Nordbakken, Cecilie V.; Valkov, Andre; Paulsen, Erna-Elise; Nordby, Yngve; Bremnes, Roy M.; Dønnem, Tom; Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)
      Programmed cell death protein 1 (PD-1) and its ligand Programmed death ligand 1 (PD-L1) have gained massive attention in cancer research due to recent availability and their targeted antitumor effects. Their role in prostate cancer is still undetermined. We constructed tissue microarrays from prostatectomy specimens from 535 prostate cancer patients. Following validation of antibodies, ...

    • Prognostic scores in brain metastases from breast cancer 

      Nieder, Carsten; Marienhagen, Kirsten; Astner, Sabrina T.; Molls, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-04-07)
      Background: Prognostic scores might be useful tools both in clinical practice and clinical trials, where they can be used as stratification parameter. The available scores for patients with brain metastases have never been tested specifically in patients with primary breast cancer. It is therefore unknown which score is most appropriate for these patients. <br> Methods: Five previously published ...

    • Prognostic value of the MicroRNA regulators dicer and drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival 

      Lønvik, Kenneth; Sørbye, Sveinung Wergeland; Nilsen, Marit Nina; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-11)
      Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. We have investigated the prognostic impact of Dicer and Drosha and their correlation with miR-126 expression in a large cohort of non-small cell lung cancer (NSCLC) patients. We aimed to find ...

    • Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium 

      Bahls, Martin; Lorenz, Matthias W.; Dörr, Marcus; Gao, Lu; Kitagawa, Kazuo; Tuomainen, Tomi-Pekka; Agewall, Stefan; Berenson, Gerald; Catapano, Alberico L.; Norata, Guiseppe D.; Bots, Michiel L.; van Gilst, Wiek; Asselbergs, Folkert W.; Brouwers, Frank P.; Uthoff, Heiko; Sander, Dirk; Poppert, Holger; Hecht Olsen, Michael; Empana, Jean Philippe; Schminke, Ulf; Baldassarre, Damiano; Veglia, Fabrizio; Franco, Oscar H.; Kavousi, Maryam; de Groot, Eric; Mathiesen, Ellisiv B.; Grigore, Liliana; Polak, Joseph F.; Rundek, Tatjana; Stehouwer, Coen D.A.; Skilton, Michael R.; Hatzitolios, Apostolos I.; Savopoulos, Christos; Ntaios, George; Plichart, Matthieu; McLachlan, Stela; Lind, Lars; Willeit, Peter; Steinmetz, Helmuth; Desvarieux, Moise; Ikram, M. Arfan; Johnsen, Stein Harald; Schmidt, Caroline; Willeit, Johann; Ducimetière, Pierre; Price, Jackie F.; Bergström, Göran; Kauhanen, Jussi; Kiechl, Stefan; Sitzer, Matthias; Bickel, Horst; Sacco, Ralph L.; Hofman, Albert; Völzke, Henry; Thompson, Simon G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)
      <i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic ...

    • Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial 

      Capion, Tenna; Lilja-Cyron, Alexander; Olsen, Markus Harboe; Juhler, Marianne; Moeller, Kirsten; Sorteberg, Angelika; Rønning, Pål Andre; Poulsen, Frantz Rom; Wismann, Joakim; Ravlo, Celina; Isaksen, Jørgen Gjernes; Lindschou, Jane; Gluud, Christian; Mathiesen, Tiit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a life-threatening disease caused by rupture of an intracranial aneurysm. A common complication following aSAH is hydrocephalus, for which placement of an external ventricular drain (EVD) is an important first-line treatment. Once the patient is clinically stable, the EVD is either removed or replaced by a ventriculoperitoneal shunt. The ...

    • Properdin binding to complement activating surfaces depends on initial C3b deposition 

      Harboe, Morten; Johnson, Christina; Nymo, Stig Haugset; Ekholt, Karin; Schjalm, Camilla; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Hellerud, Bernt C; Ekdahl, Kristina Nilsson; Mollnes, Tom Eirik; Nilsson, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-09)
      Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. The presence of nonphysiological aggregates in purified properdin preparations and experimental models that do not allow discrimination between the initial binding of properdin and binding secondary to C3b ...

    • Prophylactic Oropharyngeal Surfactant for Preterm Newborns at Birth: A Randomized Clinical Trial 

      Murphy, Madeleine C.; Miletin, Jan; Klingenberg, Claus Andreas; Guthe, Hans Jørgen Timm; Rigo, Vincent; Plavka, Richard; Bohlin, Kajsa; Barroso Pereira, Almerinda; Juren, Tomáš; Alih, Ekele; Galligan, Marie; O'Donnell, Colm P. F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-11)
      Importance - Preterm newborns at risk of respiratory distress syndrome are supported with continuous positive airway pressure (CPAP). Many newborns worsen despite CPAP and are intubated for surfactant administration, an effective therapy for treatment of respiratory distress syndrome. Endotracheal intubation is associated with adverse effects. Pharyngeal administration of surfactant to preterm animals ...

    • A prospective analysis of false positive events in a National Colon Cancer Surveillance Program 

      Augestad, Knut Magne; Norum, Jan; Rose, Johnie; Lindsetmo, Rolv-Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Prospective randomized clinical studies involving reirradiation: update of a systematic review 

      Nieder, Carsten; Willmann, Jonas; Andratschke, Nicolaus H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)
      Background Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, ...

    • Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study 

      Bjõrk, Jonas; Nyman, Ulf; Courbebaisse, Marie; Couzi, Lionel; Dalton, R. Neil; Dubourg, Laurence; Ebert, Natalie; Eriksen, Bjõrn O.; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Hansson, Magnus; Jacquemont1, Lola; Jones, Ian; Kamar, Nassim; Lamb, Edmund J.; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Turner, Stephen; Åkesson, Anna; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)
      Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ...

    • Prospects of returning to work after lumbar spine surgery for patients considering disability pension: A nationwide study based on data from the Norwegian Registry for Spine Surgery 

      Hammer, Lovise; Ingebrigtsen, Tor; Gulati, Sasha; Hara, Sozaburo; Nygaard, Øystein Petter; Hara, Karen Walseth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)
      Objectives To assess the odds for not returning to work (non-RTW) 1 year after treatment among patients who had applied for or were planning to apply for disability pension (DP-applicant) prior to an operation for degenerative disorders of the lumbar spine.<p> <p>Methods This population-based cohort study from the Norwegian Registry for Spine surgery included 26 688 cases operated for ...

    • Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin‐proteasome and autophagy‐lysosomal system 

      Franeková, Veronika; Storjord, Hilde, I.; Leivseth, Gunnar; Nilssen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)
      Aims: Limb-girdle muscular dystrophy R9 (LGMDR9) is an autosomal recessive disorder caused by mutations in the fukutin-related protein gene (FKRP), encoding a glycosyltransferase involved in α-dystroglycan modification. Muscle atrophy, a significant feature of LGMDR9, occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin–proteasome system (UPS) ...

    • Proteomics in thrombosis research 

      Edfors, Fredrik; Iglesias, Maria Jesus; Butler, Lynn; Odeberg, Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)
      A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma proteins with potential utility for such tools, could enable an individualized approach to treatment ...

    • Prothrombotic genotypes and risk of major bleeding in patients with incident venous thromboembolism 

      Johnsen, Håkon Sandbukt; Bjøri, Esben; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-22)
      <i>Background</i> - Genotypes associated with venous thromboembolism (VTE) may protect against bleeding due to a hypercoagulable state. Whether the risk of major bleeding is reduced in parallel with an increasing number of prothrombotic genotypes during anticoagulant treatment in VTE remains unknown.<p> <p><i>Objectives</i> - To investigate the association between multiple prothrombotic genotypes ...

    • Prothrombotic genotypes and risk of venous thromboembolism in occult cancer 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Severinsen, Marianne T.; Gabrielsen, Maiken Elvestad; Kristensen, Søren R.; Næss, Inger Anne; Hindberg, Kristian; Tjønneland, Anne; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      Background - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult ...