Blar i tittel Artikler, rapporter og annet (klinisk medisin)

Viser treff 1404-1423 av 1796

    • A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation 

      Østerud, Bjarne; Latysheva, Nadezhda; Schoergenhofer, Christian; Jilma, Bernd; Hansen, John-Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Background - Most tissue factor (TF) activity assays are based on measurement of factor X (FX) activation by TF in the presence of factor VII (FVII)/FVIIa. This requires long incubation, which may result in TF-independent activity of FX and inaccurate measurement of TF activity.<p> <p>Aim - To develop a sensitive and specific TF activity assay, which does not register a non-specific TF activity, ...

    • Rapport fra 25. juni-utvalget: Evaluering av PST og politiet 

      Jansen, Pia Therese; Ravndal, Jacob Aasland; Skoglund, Gisle; Eriksen, Christoffer Conrad; Hoven, Siren; Løberg, Anders; Rolfheim-Bye, Christina Lill (Research report; Forskningsrapport, 2023)

    • Rapport omsvangerskapsavbrot 2022 

      Akerkar, Rupali Rajendra; Askeland, Olaug Margrete; Halvorsen, Guri Sundgot; Heiberg-Andersen, Rannveig; Hornæs, Mona Tornensis; Juliusson, Pétur Benedikt; Berg, Amund (Research report; Forskningsrapport, 2023)
      Det føreligg statistikk over talet på begjæringar, tal på innvilga begjæringar i nemnd og tal på utførte svangerskapsavbrot i Noreg sidan 1979. Statistisk sentralbyrå hadde ansvaret for abortstatistikken frå 1979 til og med 2005. Frå og med 2006 har Folkehelseinstituttet vore ansvarleg for statistikken, og frå og med 2008 ansvarleg for databehandlinga av Register over svangerskapsavbrudd (Abo ...

    • Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1) 

      Øie, Cristina Ionica; Appa, Rupa Shree; Hilden, Ida; Petersen, Helle Heibroch; Gruhler, Albrecht; Smedsrød, Bård; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The low density lipoprotein receptor-related protein-1 (LRP-1) is a large, multifunctional endocytic receptor from the LDL receptor family, highly expressed in liver parenchymal cells (PCs), neurons, activated astrocytes, and fibroblasts. The aim of the study was to investigate if liver sinusoidal endothelial cells (LSECs), highly specialized scavenger cells, express LRP-1. To address this question, ...

    • The rates of lumbar spinal stenosis surgery in Norwegian public hospitals: a threefold increase from 1999 to 2013 

      Grøvle, Lars; Fjeld, Olaf Randall; Haugen, Anne Julsrud; Helgeland, Jon; Småstuen, Milada Cvancarova; Solberg, Tore; Zwart, John-Anker; Grotle, Margreth (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      <p><i>Study Design</i>: Retrospective administrative database study.</p> <p><i>Objective</i>: To assess temporal and regional trends, and length of hospital stay, in lumbar spinal stenosis (LSS) surgery in Norwegian public hospitals from 1999 to 2013.</p> <p><i>Summary of Background Data</i>: Studies from several countries have reported increasing rates of LSS surgery over the last decades. ...

    • Rationale and plan for vitamin D food fortification: A review and guidance paper 

      Pilz, Stefan; März, Winfried; Cashman, Kevin D; Kiely, Mairead; Whiting, Susan J; Holick, Michael F.; Grant, William B; Pludowski, Pawel; Hiligsmann, Mickaël; Trummer, Christian; Schwetz, Verena; Lerchbaum, Elisabeth; Pandis, Marlene; Tomaschitz, Andreas; Grübler, Martin; Gaksch, Martin; Verheyen, Nicolas; Hollis, Bruce W; Rejnmark, Lars; Karras, Spyridon N.; Hahn, Andreas; Bischoff-Ferrari, Heike Annette; Reichrath, Jörg; Jorde, Rolf; Elmadfa, Ibrahim; Vieth, Reinhold; Scragg, Robert; Calvo, Mona S; Van Schoor, Natasja M; Bouillon, Roger; Lips, Paul; Itkonen, Suvi T; Martineau, Adrian R; Lamberg-Allardt, Christel; Zittermann, Armin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-17)
      Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ...

    • Re-irradiation in clinical practice: Results of an international patterns of care survey within the framework of the ESTRO-EORTC E2-RADIatE platform 

      Willmann, Jonas; Appelt, L.; Balermpas, Panagiotis; Baumert, G.; de Ruysscher, Dirk; Hoyer, Morten; Hurkmans, Coen; Kaidar-Person, Orit; Meattini, Icro; Niyazi, Maximilian; Poortmans, Philip; Reynaert, Nick; Tandini-Lang, Stephanie; van der Linden, Yvette; Nieder, Carsten; Andratschke, Nicolaus (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-06)
      Background: Re-irradiation is an increasingly utilized treatment for recurrent, metastatic or new malignancies after previous radiotherapy. It is unclear how re-irradiation is applied in clinical practice. We aimed to investigate the patterns of care of re-irradiation internationally.<p> <p>Material/Methods: A cross-sectional survey conducted between March and September 2022. The survey was structured ...

    • Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study 

      van Straalen, Joeri W.; de Roock, Sytze; Giancane, Gabriella; Consolaro, Alessandro; Rygg, Marite; Nordal, Ellen Berit; Rubio-Pérez, Nadina; Jelusic, Marija; De Inocencio, Jaime; Vojinovic, Jelena; Wulffraat, Nico M.; Bruijning-Verhagen, Patricia C. J.; Ruperto, Nicolino; Swart, Joost F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-14)
      Background: Etanercept (ETN) and adalimumab (ADA) are considered equally efective biologicals in the treat‑ ment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported well-being. The objective of this study was to determine whether ETN and ADA have a diferential efect on patientreported well-being in non-systemic JIA using real-world ...

    • Recent advances in the roles of exosomal microRNAs in neuroblastoma 

      Bhavsar, Swapnil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)
      Exosomal miRNAs (exo-miRs), universally found in biofluids, tissues, and/or conditioned medium of the cell cultures play a significant role in cell - cell communication, thus driving cancer progression and metastasis. Very few studies have explored the role of exo-miRs in the progression of children’s cancer - neuroblastoma. In this mini review, I briefly summarize the existing literature on the ...

    • The recent history of the clinical case report: A narrative review 

      Nissen, Trygve; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Clinical case reporting in the form of case reports and case series reports has always been an integral part of medical literature. From the late 1970s the genre appeared to fall from grace and was marginalized in many medical journals. There was controversy as to its value as a research method. From the late 1990s and onwards, there has been an increased demand for and publication of case reports ...

    • Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep 

      Wærhaug, Kristine; Kirov, Mikhail Y.; Kuzkov, Vsevolod V.; Kuklin, Vladimir N.; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-11-20)
      Introduction: Acute lung injury (ALI) may arise both after sepsis and non-septic inflammatory conditions and is often associated with the release of fatty acids, including oleic acid (OA). Infusion of OA has been used extensively to mimic ALI. Recent research has revealed that intravenously administered recombinant human activated protein C (rhAPC) is able to counteract ALI. Our aim was to ...

    • Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep 

      Langbakk, Bodil; Wærhaug, Kristine; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Ingebretsen, Ole C.; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)
      Introduction: Acute lung injury often complicates severe sepsis. In Gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human ...

    • Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score 

      De Winter, Maria A.; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin A. H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik T.; Visseren, Frank L. J.; Wells, Philip S.; Dorresteijn, Jannick A. N.; Nijkeuter, Mathilde; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)
      Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed to develop and externally validate models for predicting 5-year risks of recurrence and bleeding in patients with VTE without cancer who completed at least 3 months of initial treatment, ...

    • Recursive partitioning analysis of systemic therapy after radiotherapy in patients with brain metastases 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03)
      Purpose: The purpose of this study was to identify factors associated with the initiation or continuation of systemic treatment after brain irradiation. The outcome of interest was a utilization rate of at least 75%, given that active extracranial disease is common in patients with brain metastases. If left untreated, extracranial disease limits survival, regardless of successful local treatment of ...

    • Red cell distribution width and carotid atherosclerosis progression: The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Vik, Anders; Skjelbakken, Tove; Brox, Jan; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-29)
      Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey ...

    • Red cell distribution width is associated with future risk of incident stroke. The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Skjelbakken, Tove; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)
      Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth ...

    • Red Cell Distribution Width Is Associated With Incident Myocardial Infarction in a General Population: The Tromsø Study 

      Skjelbakken, Tove; Lappegård, Jostein; Ellingsen, Trygve; Barrett-Connor, Elizabeth; Brox, Jan; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis 

      de Winter, Maria A.; Uijl, Alicia; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin H.A.H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik Toft; Wells, Philip S.; Nijkeuter, Mathilde; Dorresteijn, Jannick A.N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)
      Background - Patients with venous thromboembolism (VTE) are commonly classified by the presence or absence of provoking factors at the time of VTE to guide treatment decisions. This approach may not capture the heterogeneity of the disease and its prognosis.<p> <p>Objectives - To evaluate clinically important novel phenotypic clusters among patients with VTE without cancer and to explore their ...

    • Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement 

      Hauge, Karoline Kråkmo; Dahle, Gry; Bendz, Bjørn; Halvorsen, Per Steinar; Abdelnoor, Michael; Mollnes, Tom Eirik; Fosse, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
      <i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter ...

    • Reducing unwarranted variation: can a ‘clinical dashboard’ be helpful for hospital executive boards and top-level leaders? 

      Tjomsland, Ole; Thoresen, Christian; Ingebrigtsen, Tor; Søreide, Eldar; Frich, Jan C (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)
      Background/aim: In the past decades, there has been an increasing focus on defining, identifying and reducing unwarranted variation in clinical practice. There have been several attempts to monitor and reduce unwarranted variation, but the experience so far is that these initiatives have failed to reach their goals. In this article, we present the initial process of developing a safety, quality and ...