Blar i tittel Artikler, rapporter og annet (klinisk medisin)
Viser treff 221-240 av 1796
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Cerebral aneurysm morphology before and after rupture: nation-wide case series of 29 aneurysms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-06)<p><i>Background and Purpose</i>: Using postrupture morphology to predict rupture risk of an intracranial aneurysm may be inaccurate because of possible morphological changes at or around the time of rupture. The present study aims at comparing morphology from angiograms obtained prior to and just after rupture and to evaluate whether postrupture morphology is an adequate surrogate for rupture ... -
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-08)<p>Cerebral blood flow (CBF) can be measured with dynamic positron emission tomography (PET) of <sup>15</sup>O-labeled water by using tracer kinetic modelling. However, for quantification of regional CBF, an arterial input function (AIF), obtained from arterial blood sampling, is required. In this work we evaluated a novel, non-invasive approach for input function prediction based on machine learning ... -
Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-03)Objective To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies.<p> <p>Design and setting Meta-analysis based on individual participant data (IPD).<p> <p>Population or sample Ten centres provided 17 data sets for 21 661 participants, 18 731 ... -
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action.<p> <p>Methods - Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate–severe disease activity ... -
Cervical spine surgery in the Northern Norway Regional Health Authority area in 2014-18
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)<p>BAKGRUNN - Kunnskap om variasjon i behandlingsrater er nødvendig for å vurdere om tilgangen til helsetjenester er likeverdig. Formålet med denne studien var å undersøke rater for kirurgisk behandling av degenerative nakkelidelser i Norge og Helse Nord, samt egendekningen i Helse Nord, og å vurdere aktiviteten i regionen. <p>MATERIALE OG METODE - Vi inkluderte operasjoner registrert i Norsk ... -
The challenge of durable brain control in patients with brain-only metastases from breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-07)The vast majority of patients with brain metastases from breast cancer have extracranial metastases, e.g., in the liver, lungs or bones, with serious impact on prognosis. Limited research has been performed on patients with brain-only disease. We analyzed patterns of treatment, brain control and survival in uni- and multivariate analyses. All 25 patients with brain-only disease were treated with ... -
Change characteristics of health-related quality of life and its association with post-stroke fatigue at four-year follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)The long-term consequences of stroke may be highly individual and multifaceted. The question of how such individual differences may unfold and change beyond the first year after stroke may be of substantial clinical interest regarding which subgroups show more favourable and unfavourable rehabilitation trajectories. The current study explored functional trajectories from 1 to 4 years post-stroke ... -
Change in pain, disability and influence of fear-avoidance in a work-focused intervention on neck and back pain: a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-21)Background: Neck and back pain are among the most common causes of prolonged disability, and development of interventions with effect on pain, disability and return to work is important. Reduction of fear avoidance might be one mechanism behind improvement after interventions. The aim of the present study was to evaluate changes in pain and disability at the 12-month follow-up of patients with neck ... -
Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-26)Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to ... -
Changes in the human transcriptome upon vitamin D supplementation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-19)Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). The VDR is present in a wide variety of different cells types and tissues and acts as a transcription factor. Although activation of the VDR is estimated to regulate expression of up to 5% of the human genome, our study is the first analysing gene expression after supplementation ... -
Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ... -
The changing alcohol drinking patterns among older adults show that women are closing the gender gap in more frequent drinking: The Tromsø Study, 1994 – 2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)Background - As the population of older adults continues to grow, changes in alcohol consumption are important to monitor because an increase may have public health consequences. Rates of alcohol use vary with geographical location. The aim of this study was to examine trends in alcohol consumption among older adults in a geographically defined area in Norway, especially changing sex differences in ... -
Changing patterns in treatment, remission status, and categories in a long-term Nordic cohort study of juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)Objective - To explore sustainability of achieved remission off medication and defined International League of Associations for Rheumatology (ILAR) categories in juvenile idiopathic arthritis (JIA) and describe the trajectory of disease course over time by comparing treatment, disease activity, and ILAR categories from baseline, 8 years, and 18 years after disease onset.<p> <p>Methods - A total ... -
Characteristics and outcomes of patients who did not respond to a national spine surgery registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)Background Loss to follow-up may bias outcome assessments in medical registries. This cohort study aimed to analyze and compare patients who failed to respond with those that responded to the Norwegian Registry for Spine Surgery (NORspine).<p> <p>Methods We analyzed a cohort of 474 consecutive patients operated for lumbar spinal stenosis at four public hospitals in Norway during a two-year period. ... -
Characteristics of successfully implemented telemedical applications
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-07-27)Background: There has been an increased interest in the use of telemedical applications in clinical practice in recent years. Considerable effort has been invested in trials and experimental services. Yet, surprisingly few applications have continued beyond the research and development phase. The aim of this study is to explore characteristics of successfully implemented telemedical applications. ... -
Characteristics of women with chronic pelvic pain referred to physiotherapy treatment after multidisciplinary assessment: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-31)<i>Background and aims</i> - Chronic pelvic pain (CPP) in women is a complex condition that can seriously impact health and quality of life. Clinical guidelines for CPP place great demands on healthcare professionals, as they require both specialized knowledge about the pelvic area and knowledge of the mechanisms of chronic pain. To ensure best possible assessment and treatment of these women it ... -
Characterization of BRCA1 and BRCA2 variants found in a Norwegian breast or ovarian cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)Germline mutations in BRCA1 and BRCA2 cause hereditary breast and ovarian cancer. Molecular screening of these two genes in patients with a family history of breast or ovarian cancer has revealed pathogenic variants as well as genetic variants of unknown significance (VUS). These VUS may cause a challenge in the genetic counseling process regarding clinical management of the patient and the family. ... -
Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)Excessive alcohol intake can alter the gut microbiota, which may underlie the pathophysiology of alcohol-related diseases. We examined gut microbiota composition and functions in patients with alcohol overconsumption for >10 years, compared to a control group of patients with a history of no or low alcohol intake. Faecal microbiota composition was assessed by 16S rRNA sequencing. Gut microbiota ... -
Characterization of vasskveite (water halibut) syndrome for automated detection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)In recent years, cases of vasskveite (water halibut) syndrome in halibut have been increasing. At the moment, there exists no way to screen for the syndrome immediately after capture, which is problematic for both exporters and purchasers. In this article, we compared good quality halibut and halibut exhibiting the syndrome using a variety of techniques. Hyperspectral imaging was used to quantify ... -
CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-26)Background Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing in vivo resistance to anthracyclines. While we previously found TP53 mutations in the L2/L3 domains to ...