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norskBlar i tittel Artikler, rapporter og annet (klinisk medisin)
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Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy patients ... -
Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ... -
Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)<i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ... -
"Fighting the system" : families caring for ventilator-dependent children and adults with complex health care needs at home
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)An increasing number of individuals with complex health care needs now receive life-long and lifeprolonging ventilatory support at home. Family members often take on the role of primary caregivers. The aim of this study was to explore the experiences of families giving advanced care to family members dependent on home mechanical ventilation. Using qualitative research methods, a Grounded Theory ... -
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-20)Objectives: Juvenile idiopathic arthritis ( JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification system. The human leucocyte antigen (HLA) region is strongly associated with JIA. Fine-mapping of the region was performed to look for similarities and differences in ... -
First-aid training in school: amount, content and hindrances
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)<p><i>Background</i>: To increase knowledge and competence about first aid in the population, first‐aid instruction is included in primary and secondary school curricula. This study aimed to establish how much time is spent on first‐aid training, which first‐aid measures are taught, and which factors prevent teachers from providing the quantity and quality of first‐aid training that they wish to ... -
Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)We investigated if a five-year supervised exercise intervention with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) versus control; physical activity according to national guidelines, attenuated the growth of white matter hyperintensities (WMH). We hypothesized that supervised exercise, in particular HIIT, reduced WMH growth. Older adults from the general ... -
Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-27)Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing ... -
Flytting til byer fra distriktsområder med samisk bosetting
(Research report; Forskningsrapport, 2011)Senter for samisk helseforskning forbereder en survey i 2012 for personer som har flyttet fra samiske distriktsområder til byer. Undersøkelsen vil også omfatte barn av de som har flyttet. Som en innledende del ble det i samarbeid med NIBR gjennomført en registeranalyse. Denne rapporten gir noen resultater fra disse analysene. I første omgang var vi interessert i å undersøke hvor mange og hvor stor ... -
Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Background: Patients with chronic inflammatory joint diseases such as axial spondyloarthritis have traditionally received regular follow-up in specialist health care to maintain low disease activity. The follow-up has been organized as prescheduled face-to-face visits, which are time-consuming for both patients and health care professionals. Technology has enabled the remote monitoring of disease ... -
Forearm fractures–are we counting them all? An attempt to identify and include the missing fractures treated in primary care
(Journal article; Tidsskriftartikkel, 2023-07-07)Objective: Norway has a high incidence of forearm fractures, however, the incidence rates based on secondary care registers can be underestimated, as some fractures are treated exclusively in primary care. We estimated the proportion of forearm fracture diagnoses registered exclusively in primary care and assessed the agreement between diagnosis for forearm fractures in primary and secondary care. ... -
Forekomsten av angst- og depresjonssymptomer hos samiske og ikke-samiske elever i videregående skole i Finnmark i 1994 og 2014. [The prevalence of anxiety- and depression symptoms in Sami and non-Sami high school students in Finnmark county in 1994 and 2014]
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)Omtrent 15-20% av barn og unge i Norge vil i løpet av 3-18 års alderen oppleve symptomer på psykiske vansker og i hovedsak angst og depresjon. Flere internasjonale og nasjonale studier har vist at forekomsten av angst- og depressive symptomer blant ungdom har økt i løpet av de siste tiårene. Formålet med denne studien er å undersøke forekomsten av angst- og depresjonssymptomer blant samiske ... -
Forskjeller i mortalitet hos traumepasienter
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)Mortaliteten blant norske traumepasienter i perioden 2015–18 var på linje med de beste resultatene fra andre land, men fortsatt fant vi regionale forskjeller og forskjeller mellom sykehusnivåer. Selv om resultatene er bra, kan vi bli bedre. Traumer er den viktigste dødsårsaken for personer under 44 år på verdensbasis, også i vår del av verden. Mortalitet er et internasjonalt anerkjent effektmål ... -
Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)<i>Main objective</i> - The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at ... -
A four-month home-based tDCS study on patients with Alzheimer’s disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months. A total ... -
The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)<i>Background</i> - We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.<br><br> <i>Methods</i> - We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between ... -
Fukutin-Related Protein Resides in the Golgi Cisternae of Skeletal Muscle Fibres and Forms Disulfide-Linked Homodimers via an N-Terminal Interaction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Limb-Girdle Muscular Dystrophy type 2I (LGMD2I) is an inheritable autosomal, recessive disorder caused by mutations in the FuKutin-Related Protein (FKRP) gene (FKRP) located on chromosome 19 (19q13.3). Mutations in FKRP are also associated with Congenital Muscular Dystrophy (MDC1C), Walker-Warburg Syndrome (WWS) and Muscle Eye Brain disease (MEB). These four disorders share in common an incomplete/aberrant ... -
A fully-coupled fluid-structure interaction simulation of cerebral aneurysms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19): The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). Most functional studies of missense variants in BRCA1 focus on variants located within the Really Interesting New Gene (RING), coiled-coil and BRCA1 C-terminal (BRCT) ... -
Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ...
