Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model 

      Florholmen-Kjær, Åse; Goll, Rasmus; Fuskevåg, Ole-Martin; Nygård, Ingvild; Paulssen, Ruth H; Revhaug, Arthur; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-24)
      Background Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post-PHx, utilizing an analytical platform more sensitive and precise than earlier ...

    • Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis 

      Jamaly, Simin; Ramberg, Cathrine; Olsen, Randi; Latysheva, Nadezhda; Webster, Paul; Sovershaev, Timofey; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ...

    • Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Evensen, Line Holtet; Morelli, Vania Maris; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Njølstad, Inger; Mathiesen, Ellisiv B.; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...

    • Impact of red cell distribution width on future risk of cancer and all-cause mortality among cancer patients – the Tromsø Study 

      Ellingsen, Trygve; Lappegård, Jostein; Skjelbakken, Tove; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10)

    • Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. 

      Børvik, Trond; Evensen, Line; Morelli, Vania Maris; Melbye, Hasse; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
      Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO<sub>2</sub>), individually and in combination with COPD, affect the risk of VTE.<p> <p> Objectives: To investigate whether measures of respiratory impairments including respiratory symptoms ...

    • Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-01)
      Background - von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the risk of future venous thromboembolism (VTE) is unknown.<p> <p>Objectives - To investigate whether plasma ADAMTS-13 levels and an imbalance with VWF levels, assessed as the VWF/ADAMTS-13 ratio, are associated with the risk ...

    • Impact on patient-provider relationship and documentation practices when mental health patients access their electronic health records online: a qualitative study among health professionals in an outpatient setting 

      Zanaboni, Paolo; Kristiansen, Eli; Lintvedt, Ove; Wynn, Rolf; Johansen, Monika Alise; Sørensen, Tove; Fagerlund, Asbjørn Johansen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)
      Background - Patient accessible electronic health records (PAEHR) hold the potential to increase patient empowerment, especially for patients with complex, long-term or chronic conditions. However, evidence of its benefits for patients who undergo mental health treatment is unclear and inconsistent, and several concerns towards use of PAEHR emerged among health professionals. This study aimed at ...

    • Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population 

      Melsom, Toralf; Mathisen, Ulla Dorte; Ingebretsen, Ole C; Jenssen, Trond Geir; Njølstad, Inger; Solbu, Marit Dahl; Toft, Ingrid; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...

    • Implementation of international society guidelines on chorionicity determination in twins: A multi-Center cohort study in mainland China 

      Wu, Su-Wen; Zhou, Qiongjie; Xiao, Xirong; Xiong, Yu; Liang, Huan; Shen, Jie; Barrett, Jon; Wang, Hong; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      Objective: Ultrasound determination of chorionicity is poor in early pregnancy in China. In an effort to increase the accuracy rate of prompt chorionicity determination, clinical training was provided to primary care physicians. This study assesses the effects of implementing clinical guidelines on chorionicity determination.<p> <p>Methods: A multi‑centered cohort study was conducted between ...

    • Implementation of Locoregional Adjuvant Radiotherapy for Breast Cancer in a Rural Healthcare Region: Toxicity Outcomes in the Initial Cohort 

      Nieder, Carsten; Ressheim, Joakim Grønning; Haukland, Ellinor Christin; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-29)
      Background/Aim: The aim of this study was to analyze the toxicity of locoregional adjuvant breast cancer radiotherapy after implementation of this service in a rural healthcare region with long travel distance. Patients and Methods: This was a retrospective single-institution analysis of 87 consecutive female patients (the initial cohort), managed with conventionally fractionated 3-D conformal ...

    • Implementation of new guidelines in the prehospital services: a nationwide survey of Norway 

      Thorvaldsen, Nina Øye; Flingtorp, Lars Didrik; Wisborg, Torben; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)
      <i>Background</i> - A debate regarding the potential harmful effects of rigid neck collar and backboard usage among prehospital and hospital care providers in Norway provoked the development of an evidence-based guideline. “The Norwegian guideline for the prehospital management of adult trauma patients with potential spinal injury” was developed with rigorous scientific methods and published in ...

    • Implementering av DBT i en rural kontekst. [Implementing DBT in a rural context]. Psykologtidskriftet. 

      Østmo, D.; Jørund, T.; Fors, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
      ABSTRACT Background and purpose: Dialectical behaviour therapy (DBT) is a widespread evidence-based method of treating emotionally unstable personality disorder, but the method has barely been studied in a rural context. The purpose of this study is to identify rural challenges for the four treatment channels of DBT, to pinpoint implicit urban starting points in DBT, and to suggest possible adaptations ...

    • The importance of cultural awareness when planning and implementing telepsychiatric services in rural and remote areas 

      Acharibasam, Jeremiah; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-24)
      <p><i>Introduction</i>: Increasing populations and an increasing incidence of mental health problems challenge many developing countries, including Ghana. Long distances, financial limitations, lack of mental health personnel, and pessimism about the effectiveness of treatment, make it difficult for people to access help. In 2011, only 0.3% of Ghana’s 25 million population received psychiatric ...

    • The importance of loneliness in psychotic-like symptoms: Data from three studies 

      Le, Thanh P.; Cowan, Tovah; Schwartz, Elana K.; Elvevåg, Brita; Holmlund, Terje Bektesevic; Foltz, Peter W.; Barkus, Emma; Cohen, Alex S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-19)
      Poor social connection or loneliness is a prominent feature of schizotypy and may exacerbate psychosis risk. Previous studies have examined the inter-relationships between loneliness and psychosis risk, but critically, they have largely been conducted in non-clinical samples or exclusively used laboratory questionnaires with limited consideration of the heterogeneity within schizotypy (i.e., positive, ...

    • Importation of roughage to Norway - Implications for plant and animal health, zoonoses, and biodiversity. Opinion of the scientific committee of the Norwegian Scientific Committee for Food and Enviroment 

      Nesbakken, Truls; Steinshamn, Håvard; Thomsen, Iben Margrete; Basic, Dean; Klem, Thea B. Blystad; Gifstad, Tron Øystein; Kausrud, Kyrre Linné; Melby, Kjetil Klaveness; Kirkendall, Lawrence Richard; Magnusson, Christer; Måren, Inger Elisabeth; Nicolaisen, Mogens; Randby, Åshild Taksdal; Stokstad, Maria; Yazdankhah, Siamak Pour; Wendell, Per Hans Micael; Agdestein, Angelika; de Boer, Hugo; Godfroid, Jacques Xavier Leon; Jore, Solveig; Krokene, Paal; Nesse, Live Lingaas; Madslien, Knut; Møretrø, Trond; Velle, Gaute (Research report; Forskningsrapport, 2022-02-18)
      Det er stor usikkerhet om import av grovfôr til Norge kan føre med seg planteskadegjørere, invaderende planter og smittestoff som kan forårsake sykdom hos dyr og mennesker.

    • Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy 

      Lappegård, Knut Tore; Pop-Purceleanu, Monica; van Heerde, Waander L.; Sexton, Joseph; Tendolkar, Indira; Pop, Gheorghe A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new or recurrent AF. However, it is not known whether ...

    • Improving the Applicability of AI for Psychiatric Applications through Human-in-the-loop Methodologies 

      Chandler, Chelsea; Foltz, Peter W.; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-26)
      Objectives: Machine learning (ML) and natural language processing have great potential to improve effciency and accuracy in diagnosis, treatment recommendations, predictive interventions, and scarce resource allocation within psychiatry. Researchers often conceptualize such an approach as operating in isolation without much need for human involvement, yet it remains crucial to harness human-inthe-loop ...

    • In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes 

      Islam, Md Ashraful; Fossum, Vegard; Hansen, Ann Kristin; Urbarova, Ilona; Knutsen, Gunnar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
      <p><i>Background</i>: Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers that can forecast the clinical potency of the cells have been proposed, but evidence for the relationship between in ...

    • In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate 

      Tryland, Morten; Okeke, Malachy Ifeanyi; Nilssen, Øivind; Moens, Ugo; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)
      Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ...

    • In vivo perforasome perfusion in hemi-DIEP flaps evaluated with indocyanine-green fluorescence angiography and infrared thermography 

      Chaudhry, Muiz Akram; Mercer, James; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Background: There are no in vivo studies that evaluate the effect of perforator dissection on the perfusion territory of a perforator (perforasome). In this study, indocyanine green fluorescence angiography (ICG-FA) and infrared thermography (IRT) were used intraoperatively to evaluate perforasome perfusion in hemi-DIEP flaps.<p> <p>Methods: Patients selected for DIEP breast reconstruction were ...