Artikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 841-860 of 1805
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Chronic obstructive pulmonary Disease and risk of mortality in patients with venous thromboembolism - the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-30)<i>Background</i> - Previous studies have shown increased mortality in venous thromboembolism (VTE) patients with chronic obstructive pulmonary disease (COPD), but it is unknown to what extent the association is influenced by the severity of COPD and physical inactivity.<p> <p><i>Objectives</i> - This article investigates whether COPD, and stages of COPD, influenced the risk of mortality after a ... -
Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-01)<i>Objective</i> - To propose multidisciplinary, consensus-based, standardization of operational terminology and method of assessment for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA).<p> <p><i>Methods</i> - Using a sequential expert group–defined terminology and methods-of-assessment approach by (1) establishment of task force, (2) item generation, (3) working ... -
Prevalens av diabetes blant gravide og svangerskapsutfall i Nordland og Troms 2004-15
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-09)<i>BAKGRUNN</i> - Formålet var å undersøke prevalens av diabetes i svangerskapet og svangerskapsutfall hos kvinner med diabetes i svangerskapet i Nordland og Troms.<p> <p><i>MATERIALE OG METODE</i> - Vi inkluderte alle 1 067 kvinner med type 1-diabetes, type 2-diabetes og svangerskapsdiabetes blant 34 915 fødsler ved fire sykehus i Nordland og Troms fra 2004 til 2015. Prevalens av diabetes ble ... -
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)<i>Objective</i> - To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time (LLDAS‐50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus (SLE).<p><p> <i>Methods</i> - We used data from the Tromsø Lupus Cohort, a longitudinal population‐based study of all patients with SLE in the 2 northernmost counties in Norway. ... -
Data work in healthcare: An Introduction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)Why data work in healthcare?<p> <p>Healthcare organizations across the globe are currently grappling to implement tools and practices to transform data from “refuse to riches,” a movement propelled by mass adoption of electronic health records (EHRs), sensors, and servers that can hold an ever-expanding volume of digital data. Allegedly, “By digitizing, combining and effectively using big data, ... -
Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)<i>Background</i> - Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results. The effect of n-3 PUFA in patients with familial hypercholesterolemia (FH), a group with particularly high risk of cardiovascular disease, is not well established.<p><p> <i>Objective</i> ... -
Hoffmann´s syndrome necessitating forearm fasciotomy: a case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-02)<i>Background</i> - Hoffmann’s syndrome is a rare form of hypothyroid myopathy. Only a few cases of fasciotomy in this setting have previously been reported.<p><p> <i>Case presentation</i> - A 41-year-old Caucasian man under treatment for hypothyroidism presented with acute-onset severe pain in his forearm for no obvious reason and was admitted to our emergency room. He eventually developed ... -
Intrauterine progestin therapy as a new approach to premalignant endometrial polyps: A prospective observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09)Background/Aim: Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS) as therapy for EHP with malignant potential. Patients and Methods: In total, 37 women with EHP underwent therapy with LNG-IUS containing 13.5 mg levonorgestrel for six months ... -
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)<i>Objective</i>: To explore monocyte and dendritic cell immune responses, and their association with future CD4<sup>+</sup> gain in treated HIV patients with suboptimal CD4<sup>+</sup> recovery.<p> <p><i>Design</i>: A cross-sectional study of HIV-infected, virally suppressed individuals on antiretroviral therapy for at least 24 months; 41 immunological nonresponders (INRs) (CD4+ cell count <400 ... -
No additional long-term effect of group vs individual family intervention in the treatment of childhood obesity - A randomised trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)<i>Aim</i> - Long‐term evaluations of childhood obesity treatments are needed. We examined changes in weight and cardiometabolic risk 1 year after children completed individual family or group‐based weight management interventions.<p><p> <i>Methods</i> - In 2009‐2010, 6‐ to 12‐year‐old children with overweight or obesity from Finnmark and Troms (Norway) were recruited after media coverage and ... -
Determinants of trabecular bone score and prevalent vertebral fractures in women with fragility fractures: a cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-21)<i>Summary</i> - Determinants of trabecular bone score (TBS) and vertebral fractures assessed semiquantitatively (SQ1–SQ3) were studied in 496 women with fragility fractures. TBS was associated with age, parental hip fracture, alcohol intake and BMD, not SQ1–SQ3 fractures. SQ1–SQ3 fractures were associated with age, prior fractures, and lumbar spine BMD, but not TBS.<p><p> <i>Introduction</i> ... -
Quantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction maps
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)<i>Background</i> - Positron emission tomography (PET)/magnetic resonance (MR) imaging may become increasingly important for assessing tumor therapy response. A prerequisite for quantitative PET/MR imaging is reliable and repeatable MR-based attenuation correction (AC).<p> <p><i>Purpose</i> - To investigate the frequency and test–retest reproducibility of artifacts in MR-AC maps in a lung cancer ... -
Polymorphisms in the vitamin D system and mortality - The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-18)Vitamin D deficiency is associated with diabetes, cancer, immunological and cardiovascular diseases as well as increased mortality. It has, however, been difficult to show a causal relation in randomized, controlled trials. Mendelian randomization studies provide another option for testing causality, and results indicate relations between the serum 25-hydroxyvitamin D (25(OH)D) level and some diseases, ... -
Facet arthropathy evaluation: CT or MRI?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)<i>Objective</i> - To assess the reliability of lumbar facet arthropathy evaluation with computed tomography (CT) or magnetic resonance imaging (MRI) in patients with and without lumbar disc prosthesis and to estimate the reliability for individual CT and MRI findings indicating facet arthropathy.<p> <p><i>Methods</i> - Metal-artifact reducing CT and MRI protocols were performed at follow-up of ... -
Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-11)<i>Background</i> - Recurrent venous thromboembolism (VTE) is common. Current guidelines suggest that patients with unprovoked VTE should continue anticoagulants unless they have a high bleeding risk, whereas all others can stop. Prediction models may refine this dichotomous distinction, but existing models apply only to patients with unprovoked first thrombosis. We aimed to develop a prediction ... -
The effect of maternal and paternal height and weight on antenatal, perinatal and postnatal morphology in sex-stratified analyses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)<i>Introduction</i> - Low birthweight is associated with diseases later in life. The mechanisms for these associations are not well known. If the hypothesis concerning “maternal constraint” is correct for humans, as shown in animal experiments, we expect the maternal, not paternal, body proportions to influence antenatal growth and those of both parents to influence postnatal growth. We aimed to ... -
Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-19)<i>Background</i>: The NS5A resistance-associated substitution (RAS) Y93H is found quite frequently (5–10%) at baseline in direct-acting antiviral agents (DAA) treatment-naïve genotype (GT) 3a patients when studied by the population-sequencing method (cut-off 20%). This RAS may impair HCV DAA treatment response, since it possesses a high fold <i>in vitro</i> resistance to daclatasvir (DCV) and ... -
Cardiorespiratory fitness and future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-25)<i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ... -
LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a)in a large cohort of predominantly genetically verified familial hypercholesterolemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-30)<i>Background</i> - Current treatment goals for familial hypercholesterolemia (FH) recommended by the European Atherosclerosis Society (EAS) are LDL-C ≤2.5 mmol/L (∼100 mg/dL) or ≤1.8 mmol/L (∼70 mg/dL) in very high-risk subjects.<p> <p><i>Objective</i> - The objective of the present study was to investigate characteristics and treatment status in subjects with genetically verified FH followed ... -
Validation of the multiple sclerosis diagnosis in the Norwegian Patient Registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-04)<i>Background</i> - Health registries may yield important data for epidemiological studies. However, in order to be a valuable source for information, the registered data have to be correct.<p><p> <i>Objectives</i> - The aim of the study was to validate data from the Norwegian Patient Registry (NPR) regarding multiple sclerosis (MS).<p><p> <i>Materials and Methods</i> - We obtained data ...