Artikler, rapporter og annet (klinisk medisin): Nye registreringer

Viser treff 861-880 av 1805

    • Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study 

      Ihlen, Espen Alexander F.; Støen, Ragnhild; Boswell, Lynn; de-Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-Spira, Deborah; Labori, Cathrine; Loennecken, Marianne; Msall, Michael; Møinichen, Unn Inger; Peyton, Colleen; Schreiber, Michael; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Vågen, Randi; Øberg, Gunn Kristin; Adde, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      <i>Background</i>: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based on infant video recordings.<p><p> <i>Methods</i>: The CIMA model was ...

    • ABCC9-related intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9 

      Smeland, Marie Falkenberg; McClenaghan, Conor; Roessler, Helen I.; Savelberg, Sanne; Hansen, Geir Åsmund Myge; Hjellnes, Helene; Arntzen, Kjell Arne; Müller, Kai Ivar; Dybesland, Andreas R.; Harter, Theresa; Sala-Rabanal, Monica; Emfinger, Chris H.; Huang, Yan; Singareddy, Soma S.; Gunn, Jamie; Wozniak, David F.; Kovacs, Attila; Massink, Maarten; Tessadori, Federico; Kamel, Sarah M.; Bakkers, Jeroen; Remedi, Maria S.; Van Ghelue, Marijke; Nichols, Colin G.; van Haaften, Gijs (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-01)
      Mutations in genes encoding K<sub>ATP</sub> channel subunits have been reported for pancreatic disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families with a consistent phenotype of mild intellectual disability, similar facies, myopathy, and cerebral white matter hyperintensities, with cardiac systolic dysfunction present in the two oldest patients. Patients are ...

    • A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes 

      Dusart, Philip James; Hallström, Björn M.; Renne, Thomas; Odeberg, Jacob Olof; Uhlén, Mathias; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex ...

    • Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop 

      Russell, Ashley E.; Sneider, Alexandra; Witwer, Kenneth W.; Bergese, Paolo; Bhattacharyya, Suvendra N.; Cocks, Alexander; Cocucci, Emanuele; Erdbrügger, Uta; Falcón-Pérez, Juan M.; Freeman, David W.; Gallagher, Thomas M.; Hu, Shuaishuai; Huang, Yiyao; Jay, Steven M.; Kano, Shin-ichi; Lavieu, Gregory; Leszczynska, Aleksandra; Llorente Martinez, Alicia; Lu, Quan; Mahairaki, Vasiliki; Muth, Dillon C.; Hooten, Nicole Noren; Ostrowski, Matias; Prada, Ilaria; Sahoo, Susmita; Schøyen, Tine Hiorth; Sheng, Lifu; Tesch, Deanna; Van Niel, Guillaume; Vandenbroucke, Roosmarijn E.; Verweij, Frederik J.; Villar, Ana V.; Wauben, Marca; Wehman, Ann M.; Yin, Hang; Carter, David Raul Francisco; Vader, Pieter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-08)
      Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes and EVs, the International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 in Baltimore, Maryland, ...

    • Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study 

      Voomolen, DC; Haagsma, JA; Polinder, Suzanne; Maas, AIR; Steyerberg, Ewout W; Vulekovic, Peter; Sewalt, CA; Gravesteijn, BY; Covic, Amra; Andelic, Nada; Plass, AM; von Steinbüchel, Nicole; Vik, Anne; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin Kordasti; Helseth, Eirik; Skandsen, Toril; Røise, Olav; Håberg, Asta; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-08)
      Abstract The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) at three and six months post-injury. Patients were included through the prospective cohort study: Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI). Patients ...

    • Contribution of serum biomarkers to prognostic assessment in patients with oligometastatic prostate cancer 

      Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04)
      <i>Background/Aim</i>: The aim of this study was to analyze the prognostic impact of biomarkers, such as serum lactate dehydrogenase (LDH), in patients with oligometastatic castration-resistant prostate cancer, arbitrarily defined as a maximum of five metastatic lesions.<p><p> <i>Patients and Methods</i>: This was a retrospective single-institution analysis. Overall 34 patients were included, ...

    • Praktisk håndtering av hodepine 

      Aamodt, Anne Hege; Bjørk, Marte-Helene; Alstadhaug, Karl Bjørnar; Eldøen, Guttorm; Dueland, Aud Nome; Poole, Tine; Hagen, Knut; Vetvik, Kjersti; Ofte, Hilde Karen; Sønnervik, Julie; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Lundqvist, Christofer; Sagabråten, Ståle Onsgår (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-03)
      Korrekt diagnostikk av ulike hodepinetyper kan være utfordrende, men det er den viktigste forutsetningen for optimal behandling. Det anbefales kontrollert bruk av anfallsmedisin og forebyggende tiltak.<p> <p>Hodepinesykdommer er ifølge sykdomsbyrdeprosjektet Global Burden of Disease blant de vanligste årsakene til funksjonsnedsettelse (1). Lidelsene påvirker i stor grad samfunnet, personene som ...

    • Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography 

      Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukić-Stefanović, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
      A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ...

    • C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes 

      Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      <i>Objective:</i> - The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<p> <p><i>Approach and Results:</i> - Serial measurements of CXCL16 were performed ...

    • The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest 

      Kuklin, Vladimir; Akhatov, Nurlan; Kondratiev, Timofei; Konkayev, Aidos; Baigenzhin, Abai K.; Konkayeva, Maiya; Karibekov, Temirlan; Barlow, Nicholas; Tveita, Torkjel; Dahl, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-20)
      <i>Background</i> - In different models of hypoxia, blockade of opioid or N-methyl-D-aspartate (NMDA) receptors shows cardio- and neuroprotective effects with a consequent increase in animal survival. The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of ...

    • Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later 

      Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-29)
      <i>Context</i> - Cholesteryl ester transfer protein (CETP) regulates high-density lipoprotein (HDL) cholesterol levels and interaction between glucose, and HDL metabolism is central in the development of diabetes.<p> <p><i>Objective</i> - We hypothesized that CETP levels would be regulated in diabetic pregnancies. We tested the hypothesis by evaluating CETP activity measured multiple times during ...

    • Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs 

      Birgisdottir, Åsa Birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, Gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-04)
      Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The latter contains PIK3C3/VPS34, PIK3R4/VPS15, BECN1/Beclin 1 ...

    • Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium 

      Brunner, Fabian J.; Waldeyer, Christoph; Ojeda, Francisco; Salomaa, Veikko; Kee, Frank; Sans, Susana; Thorand, Barbara; Giampaoli, Simona; Brambilla, Paolo; Tunstall-Pedoe, Hugh; Moitry, Marie; Iacoviello, Licia; Veronesi, Giovanni; Grassi, Guido; Mathiesen, Ellisiv B.; Söderberg, Stefan; Linneberg, Allan; Brenner, Hermann; Amouyel, Philippe; Ferrières, Jean; Tamosiunas, Abdonas; Nikitin, Yuriy P.; Drygas, Wojciech; Melander, Olle; Jöckel, Karl-Heinz; Leistner, David M.; Shaw, Jonathan E.; Panagiotakos, Demosthenes B.; Simons, Leon A.; Kavousi, Maryam; Vasan, Ramachandran S.; Dullaart, Robin P.F.; Wannamethee, S. Goya; Risérus, Ulf; Shea, Steven; de Lemos, James A.; Omland, Torbjørn; Kuulasmaa, Kari; Landmesser, Ulf; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i> - The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term ...

    • Continuous hemodynamic monitoring in an intact rat model of simulated diving 

      Gaustad, Svein Erik; Kondratyev, Timofey; Eftedal, Ingrid; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)
      Cardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic ...

    • Symposium on "parental education" at the ICCH17 

      Ingemann, Christine; Kvernmo, Siv; Møller, Helle; Moffitt, Pertice; Tagalik, Shirley; Kuhn, Rikke L; Nilsen, Siv Eirin; Rich, Rebecca; Larsen, Christina Viskum Lytken (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)
      This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium “parental education” at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018.

    • Increased risk of fatal paediatric injuries in rural Northern Norway 

      Holter, June Alette; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      <i>Background</i> - Finnmark, Northern Norway, had a mortality rate for paediatric injury in 1998‐2007 that was more than twice the national average. We investigated whether this rate had decreased in 2008‐2015 after improvements in emergency care. We also compared the mortality rate to rates of non‐fatal injury and trauma team activation both regionally and in Norway.<p> <p><i>Methods</i> - The ...

    • Pulmonary manifestations and progression of lung disease in juvenile-onset mixed connective tissue disease 

      Hetlevik, Siri Opsahl; Flatø, Berit; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Reiseter, Silje; Mynarek, Georg; Nordal, Ellen Berit; Rygg, Marite; Lilleby, Vibke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
      <i>Objective</i> - To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue disease (JMCTD), compare pulmonary function in patients and matched controls, study associations between ILD and disease-related variables, and examine progression of pulmonary manifestations over time.<p> <p><i>Methods</i> - A cohort of 52 patients with JMCTD ...

    • Telemedicine in Resource-Limited Settings to Optimize Care for Multidrug-Resistant Tuberculosis 

      Huang, G. Khai Lin; Pawape, Gibson; Taune, Magdalene; Hiasihri, Stenard; Ustero, Pilar; O'Brien, Daniel P.; du Cros, Philipp; Graham, Steve; Wootton, Richard; Majumdar, Suman S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
      The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) poses a major threat to the global targets for TB control. In recent years, an evolving science and evidence base for MDR-TB has led to much needed changes in international guidelines promoting the use of newer TB drugs and regimens for MDR-TB, however, there remains a significant implementation gap. Due to the complexity of ...

    • Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity 

      Pain, Maria Charlene Ronessen; Hjerde, Erik; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)
      <i>Staphylococcus haemolyticus</i> is a skin commensal gaining increased attention as an emerging pathogen of nosocomial infections. However, knowledge about the transition from a commensal to an invasive lifestyle remains sparse and there is a paucity of studies comparing pathogenicity traits between commensal and clinical isolates. In this study, we used a pan-genomic approach to identify factors ...

    • Electrosurgery and temperature increase in tissue with a passive metal implant 

      Martinsen, Tormod; Pettersen, Fred-Johan; Kalvøy, Håvard; Tronstad, Christian; Kvarstein, Gunnvald; Bakken, André; Høgetveit, Jan Olav; Martinsen, Ørjan Grøttem; Grimnes, Sverre; Frich, Lars Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
      <i>Importance</i>: During monopolar electrosurgery in patients, current paths can be influenced by metal implants, which can cause unintentional tissue heating in proximity to implants. Guidelines concerning electrosurgery and active implants such as pacemakers or implantable cardioverter defibrillators have been published, but most describe interference between electrosurgery and the active implant ...