Blar i tittel Artikler, rapporter og annet (farmasi)

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    • PEGylated liposomes for topical vaginal therapy improve delivery of interferon alpha 

      Jøraholmen, May Wenche; Basnet, Purusotam; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-11)
      Recent studies regarding mucosal drug delivery indicate that nanosystems with surface-available polyethylene glycol (PEG) are able to penetrate mucus barrier, assure closer contact with the epithelium, and improve drug delivery to vagina. In the present work, we developed the mucus-penetrating PEGylated liposomes containing interferon alpha-2b (IFN α-2b), destined to provide localized therapy for ...

    • Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study 

      Volmer, Daisy; Sokirskaja, Aleksandra; Laaksonen, Raisa; Vainio, Kirsti; Sandler, Niklas; Halvorsen, Kjell H.; Kjome, Reidun Lisbet Skeide; Gizurarson, Sveinbjørn; Muceniece, Ruta; Maurina, Baiba; Dauksiene, Jurgita; Ruuben, Lilian; Björnsdottir, Ingunn; Ratassepp, Tagne; Heinämäki, Jyrki (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-13)
      With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education and research. Objectives: The aim of this study was to evaluate the current status, views on, and need for the education on MT for the pharmacy students and practicing ...

    • Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 

      Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-04)
      Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in consumer products. PFAAs cross the blood-brain-barrier and have been observed to induce adverse neurobehavioural effects in humans and animals as well as adverse effects in neuronal in ...

    • Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. 

      Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)
      Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ...

    • Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization 

      Löhr, Iren Høyland; Hülter, Nils Fredrik; Bernhoff, Eva; Johnsen, Pål Jarle; Sundsfjord, Arnfinn; Naseer, Mohammed Umaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-04)
      Objectives To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for up to two years. To identify plasmid-mediated features relevant for the outbreak dynamics, and to investigate the plasmids capability of horizontal transfer, its segregational ...

    • Perspectives for systems biology in the management of tuberculosis 

      Kontsevaya, Irina; Lange, Christoph; Comella-Del-barrio, Patricia; Coarfa, Cristian; Dinardo, Andrew R.; Gillespie, Stephen H.; Hauptmann, Matthias; Leschczyk, Christoph; Mandalakas, Anna M.; Martinecz, Antal; Merker, Matthias; Niemann, Stefan; Reimann, Maja; Rzhepishevska, Olena; Schaible, Ulrich E.; Scheu, Katrin M.; Schurr, Erwin; Abel zur Wiesch, Pia; Heyckendorf, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)
      Standardised management of tuberculosis may soon be replaced by individualised, precision medicineguided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel ...

    • The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells 

      Rustad, Eirik André Lindeløff; von Hofsten, Susannah; Kumar, Robin; Lænsman, Eirik Abrahamsen; Berge, Gerd; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
      Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ...

    • Pharmaceutical Care Network Europe definition of quality indicators for pharmaceutical care: a systematic literature review and international consensus development 

      Fujita, Kenji; Halvorsen, Kjell Hermann; Sato, Noriko; Jazbar, Janja; Modamio, Pilar; Waltering, Isabel; De Wulf, Isabelle; Westerlund, Tommy; Chen, Timothy F.; Teichert, Martina (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-30)
      Background Over the past 40 years, the tasks of pharmacists have shifted from logistic services to pharmaceutical care (PhC). Despite the increasing importance of measuring quality of care, there is no general defnition of Quality Indicators (QIs) to measure PhC. Recognising this, a working group in a European association of PhC researchers, the Pharmaceutical Care Network Europe (PCNE), was ...

    • Pharmacist's time spent: Space for Pharmacy-based Interventions and Consultation TimE (SPICE)-an observational time and motion study 

      Karia, Ajay; Norman, Richard; Robinson, Suzanne; Lehnbom, Elin; Laba, Tracey-Lea; Durakovic, Iva; Balane, Christine; Joshi, Rohina; Webster, Ruth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-02)
      Objective To describe the pharmacists’ workflow, including tasks and time spent, to better understand their work capacity.<p> <p>Design Cross-sectional, observational, time and motion study. <p>Setting Community pharmacies in Western Australia and New South Wales, Australia. <p>Participants Currently registered and practising pharmacists were approached using snowball sampling and selected ...

    • A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences 

      Garcia, Beate Hennie; Storli, Sissel Lisa; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado] 

      Garcia, Beate Hennie; Giverhaug, Trude; Høgli, June U.; Skjold, Frode; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06)
      OBJECTIVES: The aim of the study was twofold; 1) to develop a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the University Hospital of North Norway, and 2) to explore the impact of the program with regards to adherence to a medication assessment tool for secondary prevention of CHD and change in biomedical ...

    • Pharmacists’ expectations and perceptions of electronic medication management: lessons from Australia 

      Lehnbom, Elin; Baysari, MT; Westbrook, JI (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <p><i>Background - </i>Implementing electronic medication management systems (eMMS) is likely to influence established work practices. <p><i>Objective - </i>To explore Australian hospital pharmacists’ expectations of, or experiences with, eMMS. <p><i>Methods - </i>Semi-structured individual phone interviews with pharmacists from six Australian States and Territories were conducted in 2014. ...

    • Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model 

      Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)
      Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in <i>Escherichia coli</i>. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its <i>in vivo</i> activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that ...

    • Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection 

      Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Ås, Christina Gabrielsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-08)
      Introduction<p> <p>Thymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus faecalis and Staphylococcus aureus have been recognized as the cause of persistent and recurrent infections. <p>Objectives <p>The aim of this study was to characterize the ...

    • (Phospho)lipid-based nanosystems for skin administration 

      Vanić, Željka; Holsæter, Ann Mari; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10)
      Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability ...

    • The Phospholipid Vesicle-Based Drug Permeability Assay: 5. Development Toward an Automated Procedure for High-Throughput Permeability Screening 

      Flaten, Gøril Eide; Awoyemi, Opeyemi Linda Ronke; Luthman, Kristina; Brandl, Martin; Massing, Ulrich (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02)
      In-vitro screening for oral absorption has become an essential part of drug discovery and development. Recently, a new phospholipid vesicle-based permeation assay was developed which has shown to satisfyingly predict passive absorption of drugs in humans. The purpose of the current study was to investigate whether the assay may be further developed into a high-throughput tool by automating its ...

    • Phospholipid Vesicle-Based Permeation Assay and EpiSkin in Assessment of Drug Therapies Destined for Skin Administration 

      Engesland, André; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy 

      Javary, Joaquim; Goupil, Eugénie; Soulez, Mathilde; Kanshin, Evgeny; Bouchard, Antoine; Seternes, Ole Morten; Thibault, Pierre; Labbé, Jean-Claude; Meloche, Sylvain (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)
      Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used large-scale quantitative phosphoproteomics and targeted gene silencing to identify direct ERK3 substrates ...

    • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

      Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...

    • Physical stability of an all-in-one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs 

      Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-07)
      <p><I>Objectives</I>: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal.</p> <p><I>Methods</I>: Seven drugs ...