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miR-126 as a prognostic marker in non-GIST soft tissue sarcoma
(Master thesis; Mastergradsoppgave, 2014-04-10)The aim of the study was to study the prognostic impact of miRNAs in non-GIST soft tissue sarcoma. The method used was microarray-based miRNA expression profiling of all verified human miRNAs on a selected number of samples. Selection criteria was time of survival (long and short). Then, the significance of miR-126 expression for disiease-specific survival in the total patient cohort of non-GIST ... -
mir-34a targets cell cycle genes CCND1 (cyclin D1) and MYCN, while mir-21 does not target PTEN and PDCD4 in neuroblastoma
(Master thesis; Mastergradsoppgave, 2013-06-03)Neuroblastoma is an embryonal cancer of the post-sympathetic nervous system and is the most frequent extra-cranial solid tumor in childhood. Two important microRNAs, the tumor suppressor mir-34a and the oncogenic mir-21, have been found to increase during MYCN-knockdown induced differentiation. However their distinct roles are not clear. This thesis employs a method to identify the mRNA targets of ... -
MiR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-16)Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV ... -
MiRNAs‐181a/b therapy in lung cancer: reality or myth?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)Despite substantial progress in oncology, lung cancer remains the number one malignancy in terms of both incidence and mortality rates, and there thus remains an urgent need for new therapeutic alternatives. MicroRNA (miRNA) have an important role in cancer initiation and progression due to their capacity to interfere with transcriptional signaling and regulate key cellular processes. miR‐181a and ... -
Mis-splicing of the insulin gene in BK-virus infected cells. Dependent on virus transformation
(Master thesis; Mastergradsoppgave, 2006-09) -
Misinformation about Covid-19 Vaccines on Social Media: Rapid Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-04)Background: The development of COVID-19 vaccines has been crucial in fighting the pandemic. However, misinformation about the COVID-19 pandemic and vaccines is spread on social media platforms at a rate that has made the World Health Organization coin the phrase infodemic. False claims about adverse vaccine side effects, such as vaccines being the cause of autism, were already considered a threat ... -
Mitigating the environmental impact of NSAIDs - physiotherapy as a contribution to one health and the SDGs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-27)Non-steroidal anti-inflammatory drugs (NSAIDs) continue to be amongst the most frequently used pharmaceutical treatments for mild to moderate musculoskeletal pain globally. In this short communication, we continue to expand the growing field of environmental physiotherapy by tracing NSAIDs journey through aquatic ecosystems, and the potential of physiotherapy to mitigate these negative environmental ... -
Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-17)<p><i>Background</i>: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).</p> <p><i>Methods</i>: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number ... -
Mitochondrial genome variation of Atlantic cod
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-19)Objective:<br> The objective of this study was to analyse intraspecifc sequence variation of Atlantic cod mitochondrial DNA, based on a comprehensive collection of completely sequenced mitochondrial genomes. <br>Results:<br> We determined the complete mitochondrial DNA sequence of 124 cod specimens from the eastern and western part of the species’ distribution range in the North Atlantic Ocean. ... -
Mitogen-activated protein kinase-activated protein kinase 5 - Structure, function and inhibition
(Doctoral thesis; Doktorgradsavhandling, 2014-09-26)Protein kinases have become central in the efforts to understand the nature of various diseases, and a lot is invested into creating effective therapeutic strategies and finding effective and selective protein kinase inhibitors. In order to succeed it is also important to focus on the structure of the kinases, their exact biological role, and how they interact and cooperate in the signaling. The ... -
A mitogenomic approach to the taxonomy of pollocks. Theragra chalcogramma and T. finnmarchica represent one single species
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-06-07)Background: The walleye pollock (Theragra chalcogramma) and Norwegian pollock (T. finnmarchica) are confined to the North Pacific and North Atlantic Oceans, respectively, and considered as distinct species within the family Gadidae. We have determined the complete mtDNA nucleotide sequence of two specimens of Norwegian pollock and compared the sequences to that of 10 specimens of walleye pollock ... -
A Mixed-Method Study on Correlates of HIV-Related Stigma Among Gay and Bisexual Men in the Southern United States
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07)Societal prejudice against people living with HIV infection is a formidable public health challenge that can negatively impact health and well-being. We recruited a multiethnic sample of 129 gay and bisexual men living with HIV who completed a brief survey; a subset of participants completed semi-structured qualitative interviews to contextualize the data. In bivariate analyses, stigma was ... -
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-14)Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and ... -
Mobbing i skolen : en litteraturgjennomgang av eksisterende forskning, og undersøkelse av skolens tiltak for å bekjempe og forebygge mobbing
(Master thesis; Mastergradsoppgave, 2010-05-14)“Alle elevar i grunnskolar og vidaregåande skolar har rett til eit godt fysisk og psykososialt miljø som fremjar helse, trivsel og læring” (Opplæringslova, 1998). Det ble gjort en litteraturgjennomgang av eksisterende forskning på feltet mobbing i forhold til nasjonale og kommunale føringer for arbeid mot mobbing i norske grunnskoler. Samtidig ble 35 grunnskoler i en stor norsk bykommune undersøkt ... -
Mobbing, sosiale medier - og oss andre
(Chronicle; Kronikk, 2013)Vi leser stadig i avisene om ungdom som blir hetset på forskjellige måter på sosiale media – oftest er Facebook nevnt, men også andre. Dessuten kan en del oppleve ganske traumatiske situasjoner knyttet til sex-relaterte bilder. -
Mobile app as a tool to collect health data: a survey on vaccination against COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)Objective. To evaluate the feasibility of using a mobile app to collect health-related data and the impact of this data collection method on the results obtained, using the COVID-19 vaccination attitude assessment as an example. Material and methods. A survey was conducted on attitudes towards COVID-19 vaccination using the «Know Your Heart» mobile app. A total of 1,770 Arkhangelsk region residents ... -
Mobile genetic elements causing plasticity in E. faecium
(Doctoral thesis; Doktorgradsavhandling, 2017-03-24)I helseinstitusjoner vancomycin-resistente enterokokker en fryktet bakterie som kan lage alvorlig infeksjonssykdom i pasienter med dårlig immunforsvar, og er vanskelig å behandle. Avhandlingen fokuserer på vancomycin-resistente enterokokker (VRE), og hvordan disse bakteriene gjennom å overføre gener mellom hverandre kan utvikle resistens mot antibiotika. Vi har analysert to utbrudd av VRE i Sverige ... -
A mobile phone-based serious game for children with type 1 diabetes
(Master thesis; Mastergradsoppgave, 2013-06-12)Purpose The purpose of this research was to develop a mobile phone-based educational game for children with type 1 diabetes. The game was expected to provide basic diabetes-related knowledge and help children improve their self-management skills. Motivation Diabetes as one of the most common non-communicable diseases worldwide is rapidly increasing in children and adolescents in many ... -
Mobile videoconferencing for enhanced emergency medical communication - a shot in the dark or a walk in the park? ‐‐ A simulation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Background: Videoconferencing on mobile phones may enhance communication, but knowledge on its quality in various situations is needed before it can be used in medical emergencies. Mobile phones automatically activate loudspeaker functionality during videoconferencing, making calls particularly vulnerable to background noise. The aim of this study was to investigate if videoconferencing can be ... -
Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-10)Background: Disability in older adults is associated with loss of independence, institutionalization, and death. The aim of this study was to study the association between the Timed Up and Go (TUG) test and all-cause mortality in a population-based sample of older men and women. <p> Methods: Our study population was home dwellers aged 65 and above, who participated in the fifth wave of the Tromsø ...
