Oral squamous cell carcinomas (OSSCs) are aggressive tumors often associated with a low survival rate. The immune system influences the development of OSCCs, and the immune infiltrate surrounding the cancer cells is an indicator of the host’s anti-tumor response. The main aim of this thesis was to describe how the tumor microenvironment in OSCC is organized, and to determine whether different subsets ...

Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and multicausal disease. Obesity is a major and likely causal risk factor for VTE. However, to what extent obesity contributes to VTE risk in the general population and the mechanism of obesity-related VTE remain poorly understood. The overall aim of this thesis was (i) to ...

Perinatal periode er en krevende overgang i livet, som medfører økt risiko for psykiske helseutfordringer. Nedsatt psykisk helse hos foreldrene utgjør risiko for foreldre-barn relasjonen og for barnets utvikling. Gjennom samspillet med sine omsorgsgivere utvikler barnet emosjonsregulering og sosiale ferdigheter. Foreldre som blir fanget i repeterende negative tanker kan ha lite kapasitet til å plukke ...

The aim of this study is to develop knowledge about how health profession students learn interprofessional collaboration in group meetings during a joint voluntary period of practice. It is an observational study. Interprofessional student groups were followed throughout a two-week practice period. The groups had a mandate to independently develop interprofessional collaboration in the healthcare ...

<p><i>Background:</i> Onset of depression and psychological distress increase dramatically during adolescence. In adults, research has indicated that low-grade inflammation and short sleep duration are risk factors for depression. Less research has been conducted on these risk factors in healthy adolescents. <p><i>Methods:</i> This thesis explores associations between two respective exposures 1) ...

Anxiety and depression are the most prevalent mental health problems among children and adolescents, and the consequences can be harmful if they are left untreated. Providing short and effective treatment for this group is paramount. When this effectiveness study of The Structured Material for Therapy (SMART) was conducted, it was the first Randomized Controlled Trial (RCT) of short-term transdiagnostic ...

<p><i>Background:</i> Critical illness not only disrupts the patient’s life, but also the lives of close family members. The care provided by ICU nurses and physicians can reduce the family members’ burden and improve the patient's outcome. Previous research shows that although ICU families generally report high satisfaction, there are several barriers to family care and areas for improvement. Family ...

Research has demonstrated that inflammation is a central part of several psychiatric disorders, of which depression in the most researched condition. Most studies have, however, been conducted on younger adults, and studies on elderly are scarce. This thesis explores the possible association between systemic markers of inflammation and characteristics of older psychiatric patients. In study I, ...

Målet med forskningsprosjektet var å belyse variasjon i behandling og utfall etter hoftebrudd i Norge, kartlegge forklaringer på og konsekvensene av variasjon, vurdere risikofaktorer for død etter hoftebrudd og deres relative betydning. I tillegg ønsket man å vurdere overlevelsesmønsteret og estimere varigheten av overdødelighet etter hoftebrudd. Prosjektet var en observasjonsstudie ...

<p><i>Background:</i> Health anxiety (HA) concerns worry of disease, and has mostly been examined in people with severe HA/hypochondriasis. However, HA can be conceptualised as a continuous construct, with levels ranging from low to severe. There is little knowledge on the distribution of HA as a continuous construct in the general population, nor the association between different levels of HA and ...