Viser treff 401-420 av 723

    • Calanus oil and its lipid constituents - Impact on obesity and obesity-related metabolic disorders in rodents 

      Höper, Anje Christina (Doctoral thesis; Doktorgradsavhandling, 2014-02-26)
      Fedme er et økende helseproblem, og spesielt er avleiring av bukfett forbundet med økt risiko for en rekke sykdommer. Kosttilskudd med omega-3 fettsyrer har vist positive effekter på fedme-relaterte sykdommer. Calanusolje er et relativt nytt produkt som produseres fra raudåte (Calanus finmarchicus) som finnes i store mengder i norske farvann. Oljen har lavt innhold av miljøgifter og er rik på ...
    • Venous thromboembolism and cancer 

      Gran, Olga Vikhammer (Doctoral thesis; Doktorgradsavhandling, 2017-06-27)
      Venous thromboembolism (VTE) is a collective term for deep vein thrombosis and pulmonary embolism. VTE is a common cause of mortality and morbidity in patients with cancer, and may also be the first sign of an underlying malignancy. The first aim of this thesis was to investigate the risk of incident and recurrent VTE in active cancer compared to a cancer-free reference population and to explore the ...
    • Systematic reporting of pre-hospital major incident medical management - identifying needs, a suggested solution and assessing implementation 

      Fattah, Sabina (Doctoral thesis; Doktorgradsavhandling, 2017-06-16)
      Storulykker er krevende for prehospitale medisinske tjenester over hele verden. Vi vet at de samme problemene viser seg gang på gang. Hvordan kan de prehospitale tjenestene lære av tidligere erfaringer? På grunn av storulykkers (engelsk: major incidents) omfattende betydning for menneskeliv og samfunn er det nødvendig å standardisere rapporteringen fra hendelsene. Dette kan muliggjøre analyser ...
    • The prognostic impact of immune-related markers in non-small cell lung cancer 

      Hald, Sigurd Mathiesen (Doctoral thesis; Doktorgradsavhandling, 2017-06-15)
      Lung cancer is the leading cancer killer worldwide and non-small cell lung cancer (NSCLC) is the predominant subtype of lung cancer. The immune system plays an important role in cancer development. Immune-related markers expressed in the tumor microenvironment of resection specimens predict prognosis in many cancers, and may be potential targets for therapy. We aimed to characterize the expression ...
    • Interaction and mutuality in physical therapy for preterm infants and their parents 

      Håkstad, Ragnhild Barclay (Doctoral thesis; Doktorgradsavhandling, 2017-06-15)
      In Norway, PTs in the municipalities deliver family-centered services to preterm infants and their parents. In addition to the prevention, detection and treatment of motor impairments, PTs are expected to educate parents and help them adapt to life with a preterm infant. In this doctoral project, we investigated physical therapy for preterm infants and their parents during the first year post-hospital ...
    • Endocrine-related factors and risk of venous thromboembolism 

      Lerstad, Gunhild (Doctoral thesis; Doktorgradsavhandling, 2017-05-31)
      Even though many environmental and inherited predisposing factors have been associated with venous thromboembolism (VTE), still 30–50% of the events have no obvious provoking factors. There is limited knowledge concerning the association between endocrine-related factors and VTE risk. Therefore we aimed to investigate the relation between hyperglycemia, thyroid function, vitamin D, calcium, ...
    • Wound healing in diabetes. An intervention study in db/db mice 

      Berdal, Margrete (Doctoral thesis; Doktorgradsavhandling, 2017-06-09)
      The prevalence of diabetes is increasing globally. Certain microvascular and macrovascular complications such as cardiovascular disease, retinopathy, nephropathy, neuropathy, and impaired wound healing are associated with the disease. Prolonged exposure to hyperglycaemia plays an important role in their development. Glucose reacts with macromolecules including proteins, lipoproteins, and nucleic ...
    • Bidirectional association between arterial and venous thrombosis 

      Lind, Caroline (Doctoral thesis; Doktorgradsavhandling, 2017-06-22)
      Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), has been considered a separate disease from arterial cardiovascular diseases (CVD, i.e. myocardial infarction (MI) and ischemic stroke). However, recent studies have proposed an association between VTE and arterial CVD. The aim of the thesis was to investigate this association in a general ...
    • Incipient changes in ICU patients’ clinical conditions – signs, nurses’ assessment and the dialogue between nurses and physicians 

      Kvande, Monica Evelyn (Doctoral thesis; Doktorgradsavhandling, 2017-06-09)
      Providing safe care for patients in intensive care units (ICUs) requires both awareness and perception of the signs indicating changes in a patient’s condition at an early stage. In addition, ensuring high-quality health care and patient safety in the ICU requires an effective exchange of patient information among health professionals. The overall aims of this study were to explore the phenomenon ...
    • Uric acid and adiponectin in cardiovascular disease 

      Norvik, Jon Viljar (Doctoral thesis; Doktorgradsavhandling, 2017-04-20)
      Uric acid, a product of metabolism, was discovered a quarter of a millennium ago and has been known to be a possible cardiovascular risk factor for well over a century. A much newer discovery, adiponectin, was discovered only a little more than 20 years ago as a protein hormone secreted by adipose tissue and has attracted substantial attention for its association with cardiovascular disease. This ...
    • Social media and sexual health – New arenas for information on sexually transmitted infections and promotion of healthy sexual behavior 

      Gabarron, Elia (Doctoral thesis; Doktorgradsavhandling, 2017-05-05)
      Objectives: The objectives of this thesis are to investigate the use of social media for health promotion dealing with sexually transmitted infections, their value for improving health and increasing the promotion reach, and to provide examples on how social media users retrieve information about sexually- transmitted infections from these media. I want to investigate the nature of the information ...
    • Sacral neuromodulation and injection of bulking agents for faecal incontinence and concomitant pelvic floor dysfunction 

      Rydningen, Mona Birgitte (Doctoral thesis; Doktorgradsavhandling, 2017-05-12)
      Aim: The overall aim of the PhD thesis was to investigate different aspects of treatment with sacral neuromodulation (SNM) and injection of bulking agents (Permacol®) for faecal incontinence (FI) and concomitant pelvic floor dysfunction in women with a history of obstetric anal sphincter injuries (OASIS). <p>Method: Consecutive women with severe FI following OASIS after failure of conservative ...
    • Change and predictors of rate of change in the treatment of children and adolescents with emotional disorders: A naturalistic observational study in two child and adolescent mental health services in Norway 

      Nilsen, Toril Sørheim (Doctoral thesis; Doktorgradsavhandling, 2017-05-15)
      The goals of this dissertation was to evaluate the rate of change, and associations between demographic and clinical characteristics and rate of change, for children and adolescents with anxiety and/or depression that had been treated within two Child and Adolescent Mental Health Services (CAMHS) in the North of Norway. The study was of naturalistic observational type. Data from clinical instruments ...
    • Decline in resting heart rate, its association with other variables, and its role in cardiovascular disease The Tromsø Study 

      Sharashova, Ekaterina (Doctoral thesis; Doktorgradsavhandling, 2017-02-10)
      Background: Resting heart rate (RHR) is an easily measured cardiovascular parameter that is considered an independent predictor of cardiovascular disease (CVD) and mortality in the general population. However, results on the association between RHR and these outcomes are inconsistent, and studies on longitudinal trends in RHR and the role of long-term changes in RHR in CVD and mortality are scarce. ...
    • Oral health literacy in adult dental patients - A clinical study 

      Stein, Linda Maria (Doctoral thesis; Doktorgradsavhandling, 2015-05-13)
      Oral health literacy encompasses individuals’ capacity to obtain, process, and understand basic oral health information and services needed to make appropriate health decisions. Evidence suggests that limited oral health literacy inhibit patients from getting necessary oral health information, and that communication with dental professionals may be problematic. Various personality traits are also ...
    • Brukermedvirkning i distriktspsykiatriske sentre - et interaksjonsteoretisk perspektiv. Praktisering av "brukermedvirkning" i fellesrom og rapporter 

      Mathisen, Vår (Doctoral thesis; Doktorgradsavhandling, 2017-04-28)
      Formålet for studien har vært å få kunnskap om hvordan fagpersoner organiserer og utøver brukermedvirkning som en del av det daglige arbeidet i døgnavdelinger i distriktspsykiatriske sentre i Norge. Et interaksjonsteoretisk perspektiv er brukt for å studere brukermedvirkning som praktisk arbeid. Metoden er kvalitativ. Datainnsamling i denne studien har foregått ved hjelp av feltarbeid, inspirert av ...
    • Mobile genetic elements causing plasticity in E. faecium 

      Sivertsen, Audun (Doctoral thesis; Doktorgradsavhandling, 2017-03-24)
      I helseinstitusjoner vancomycin-resistente enterokokker en fryktet bakterie som kan lage alvorlig infeksjonssykdom i pasienter med dårlig immunforsvar, og er vanskelig å behandle. Avhandlingen fokuserer på vancomycin-resistente enterokokker (VRE), og hvordan disse bakteriene gjennom å overføre gener mellom hverandre kan utvikle resistens mot antibiotika. Vi har analysert to utbrudd av VRE i Sverige ...
    • Novel inotropic strategies for treating acute heart failure: A large animal study on cardiac function and energetics 

      Bakkehaug, Jens Petter (Doctoral thesis; Doktorgradsavhandling, 2017-02-16)
      Acute heart failure (AHF) is a disease with a mortality ranging from 5 to 40% depending on severity, despite modern revascularization techniques after acute myocardial thromboembolism. In this thesis we have investigated two new concepts of treating AHF. In paper 1 we investigated the combination of dobutamine and ivabradine (D+I) in a porcine model of stunning AHF. Ivabradine attenuated the ...
    • Managing exacerbations of chronic obstructive pulmonary disease - An investigation of treatment decisions from a primary care perspective 

      Laue, Johanna (Doctoral thesis; Doktorgradsavhandling, 2017-03-24)
      Exacerbations of chronic obstructive pulmonary disease (COPD) compose a considerable burden for both patients and health care systems. Optimal management in primary care, including self-treatment of COPD exacerbations with antibiotics and oral corticosteroids, is considered to be one key for providing good care for patients at reasonable costs. This thesis aimed to explore treatment of COPD exacerbations ...
    • Immunological markers in non-small cell lung cancer (NSCLC) 

      Paulsen, Erna-Elise (Doctoral thesis; Doktorgradsavhandling, 2017-02-17)
      Lung cancer is the leading cause of cancer-related mortality worldwide, and novel prognostic factors supplementing the TNM classification are needed. The type, density and location of immune cell subsets in the tumor microenvironment (“Immunoscore”) may influence patient outcome in cancers, including non-small cell lung cancer (NSCLC). Tumor infiltrating cytotoxic (CD8+) T cells, the major anticancer ...