Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

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    • Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts 

      Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; Larsson, Per; Miftakhova, Regina; Persson, Karina; Askarian, Fatemeh; Johannessen, Mona; Hofsten, Jonas von; Persson, Jenny L.; Erhardt, Marc; Tuck, Simon; Uhlin, Bernt Eric; Wai, Sun Nyunt (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-07)
      Using <i>Caenorhabditis elegans</i> as an infection host model for <i>Vibrio cholerae</i> predator interactions, we discovered a bacterial cytotoxin, MakA, whose function as a virulence factor relies on secretion via the flagellum channel in a proton motive force-dependent manner. The MakA protein is expressed from the polycistronic <i>makDCBA</i> (<i>m</i>otility-<i>a</i>ssociated <i>k</i>illing ...

    • Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Zamora-Ros, R; Sacerdote, C; Ricceri, F; Weiderpass, Elisabete; Roswall, N; Buckland, G; St-Jules, DE; Overvad, K; Kyrø, C; Fagherazzi, G; Kvaskoff, M; Severi, G; Chang-Claude, J; Kaaks, R; Nöthlings, U; Trichopoulou, A; Naska, A; Trichopoulos, D; Palli, D; Grioni, S; Mattiello, A; Tumino, R; Gram, Inger Torhild; Engeset, Dagrun; Huerta, JM; Molina-Montes, E; Argüelles, M; Amiano, P; Ardanaz, E; Ericson, U; Lindkvist, B; Nilsson, LM; Kiemeney, L; Ros, M; Bueno-de-Mesquita, HB; Peeters, PHM; Khaw, KT; Wareham, NJ; Knaze, V; Romieu, I; Scalbert, A.; Brennan, P; Wark, P; Vineis, P; Riboli, E; González, CA (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS 

      Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5′ UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized to trigger the pathogenesis of FXTAS. While increased expression of FMRpolyG leads ...

    • Forty years of allocated seats for Sami medical students : has preferential admission worked? 

      Gaski, Margrete; Abelsen, Birgit; Hasvold, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)
      This article examines the effects of a special admission policy for Sami medical students in Norway. In the 1960s, public health and health care were found to be poorer in Sami communities than in the rest of Norway. There were few doctors and none of them spoke Sami. Sami school leavers found it difficult to gain admittance to medical schools. In response to this situation, the medical faculty at ...

    • From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology 

      Hira, Jonathan; Uddin, Md Jalal; Haugland, Marius Myreng; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-26)
      Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time. In this review article we will illustrate the evolving design of chemical probes in modern chemical biology and their diverse applications in bacterial imaging and phenotypic analysis. We will ...

    • From fixed-dried to wet-fixed to live-comparative super-resolution microscopy of liver sinusoidal endothelial cell fenestrations 

      Szafranska, Karolina; Neuman, Tanja; Baster, Zbigniew; Rajfur, Zenon; Szelest, Oskar; Holte, Christopher Florian; Kubisiak, Agata; Kus, Edyta; Wolfson, Deanna; Chlopicki, Stefan; Ahluwalia, Balpreet Singh; Lekka, Malgorzata; Szymonski, Marek; McCourt, Peter Anthony; Zapotoczny, Barlomiej (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-20)
      Fenestrations in liver sinusoidal endothelial cells (LSEC) are transcellular nanopores of 50–350 nm diameter that facilitate bidirectional transport of solutes and macromolecules between the bloodstream and the parenchyma of the liver. Liver diseases, ageing, and various substances such as nicotine or ethanol can negatively influence LSECs fenestrations and lead to defenestration. Over the years, ...

    • FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs 

      Dragomir, Mihnea Paul; Manyam, Ganiraju C; Ott, Leonie Florence; Berland, Léa; Knutsen, Erik; Ivan, Cristina; Lipovich, Leonard; Broom, Bradley M.; Calin, George A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)
      Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading ...

    • Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays 

      Bassi, Nicola; Hovland, Henrikke Nilsen; Rasheed, Kashif; Ghelue, Marijke van (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-21)
      Background - Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein. In addition, the BRCA1 protein is involved in ...

    • Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer 

      Moens, Ugo; Prezioso, Carla; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      As their name indicates, polyomaviruses (PyVs) can induce tumors. Mouse PyV, hamster PyV and raccoon PyV have been shown to cause tumors in their natural host. During the last 30 years, 15 PyVs have been isolated from humans. From these, Merkel cell PyV is classified as a Group 2A carcinogenic pathogen (probably carcinogenic to humans), whereas BKPyV and JCPyV are class 2B (possibly carcinogenic ...

    • Functional selectivity and antidepressant activity of serotonin 1A receptor ligands 

      Chilmonczyk, Zdzislaw; Bojarski, Andrzej Jacek; Pilc, Andrzej; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the ...

    • FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy 

      Olsvik, Hallvard Lauritz; Lamark, Trond; Takagi, Kenji; Larsen, Kenneth Bowitz; Evjen, gry; Øvervatn, Aud Karin; Mizushima, Tsunehiro; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-14)
      FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction. We have previously shown that FYCO1 binds to LC3B via a 19-amino acid sequence containing a putative core LC3-interacting ...

    • Fysisk aktivitet og effekt på hjertesykdom og død 

      Morseth, Bente; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Helt siden 1700-tallet har man kjent til at fysisk aktivitet har gunstig effekt på mennesker med koronar hjertesykdom, og i dag anbefales en aktiv livsstil som et ledd i forebygging av hjerte- og karsykdom. Anbefalingene er fundert på en etter hvert stor mengde dokumentasjon som samlet viser at fysisk aktivitet reduserer risikoen for hjerte- og karsykdom og prematur død. I denne artikkelen ...

    • The GABAB Receptor - Structure, Ligand Binding and Drug Development 

      Evenseth, Linn Samira Mari; Gabrielsen, Mari; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-07)
      The γ-aminobutyric acid (GABA) type B receptor (GABA<sub>B</sub-R) belongs to class C of the G-protein coupled receptors (GPCRs). Together with the GABA<sub>A</sub> receptor, the receptor mediates the neurotransmission of GABA, the main inhibitory neurotransmitter in the central nervous system (CNS). In recent decades, the receptor has been extensively studied with the intention being to understand ...

    • Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity 

      Raffelsberger, Niclas Peter; Hetland, Marit Andrea Klokkhammer; Svendsen, Kristian; Småbrekke, Lars; Löhr, Iren Høyland; Andreassen, Lotte; Brisse, Sylvain; Holt, Kathryn E.; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Gravningen, Kirsten Midttun (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-28)
      Antibiotic resistant <i>Klebsiella pneumoniae</i> is a leading public health threat and gastrointestinal carriage is an established risk factor for subsequent infections during hospitalization. Our study contributes new knowledge of risk factors for gastrointestinal carriage and the genomic population structure of <i>K. pneumoniae</i> colonizing humans in a representative sample of a general population ...

    • Gender differences in prevalence and associations for use of CAM in a large population study. 

      Kristoffersen, Agnete Egilsdatter; Stub, Trine; Salamonsen, Anita; Musial, Frauke; Hamberg, Katarina (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-03)

    • A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer 

      Skjefstad, Kaja Konstanse; Johannessen, Charles; Grindstad, Thea K.W.; Kilvær, Thomas Karsten; Paulsen, Erna Elise; Pedersen, Mona Irene; Dønnem, Tom; Andersen, Sigve; Bremnes, Roy M.; Richardsen, Elin; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
      Micro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in NSCLC tissue. Tissue from 553 ...

    • Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of Angiotensin II 

      Aljabri, Mohammad Belal; Lund, Trine; Høper, Anje Christina; Andreasen, Thomas Vennø; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Gene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin II 

      Aljabri, Mohammad Belal; Lund, trine; Høper, Anje Christina; Andreasen, thomas vennØ; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-19)
      To examine the response to chronic high-dose angiotensin II (Ang II) and a proposed milder response in female hearts with respect to gene expression and ischemic injury. Female and male litter–matched rats were treated with 400 ng kg<sup>-1</sup> min<sup>-1</sup> Ang II for 14 days. Hearts were isolated, subjected to 30-min ischemia and 30-min reperfusion in combination with functional monitoring ...

    • Gene variations in oestrogen pathways, CYP19A1 , daily 17ß-estradiol and mammographic density phenotypes in premenopausal women. 

      Flote, Vidar Gordon; Furberg, Anne-Sofie; McTiernan, Anne; Frydenberg, Hanne; Ursin, Giske; Iversen, Anita; Lofterød, Trygve; Ellison, Peter T.; Wist, Erik; Egeland, Thore; Wilsgaard, Tom; Makar, Karen W; Chang-Claude, Jenny; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-19)

    • General practitioners' role in cancer care : a French-Norwegian study 

      Demagny, Lise; Holtedahl, Knut A.; Thorsen, Tommy A Garden; Bachimont, Janine; Letourmy, Alain; Bungener, Martine (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)