Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

Viser treff 381-400 av 1054

    • The genome sequence of Atlantic cod reveals a unique immune system 

      Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-08-10)
      Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture1, 2. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 ...

    • The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay 

      Hjerde, Erik; Holden, Matthew TG; Seeger, Kathy; Lorentzen, Marit Sjo; Bason, Nathalie; Paulsen, Steinar; Willassen, Nils Peder; Churcher, Carol; Harris, David; Norbertczak, Halina; Quail, Michael A; Sanders, Suzanne; Thurston, Scott; Parkhill, Julian; Thomson, Nicholas R (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-19)
      <b>Background:</b> The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo.<BR><BR> <b>Results:</b> In total, 4 286 protein coding sequences were identified, and the 4.6 Mb genome of A. salmonicida has a six partite architecture with two chromosomes and four ...

    • A genome-wide "pleiotropy scan" does not identify new susceptibility Loci for estrogen receptor negative breast cancer 

      Campa, D; Barrdahl, M; Tsilidis, KK; Severi, G; Diver, WR; Siddiq, A; Chanock, S; Hoover, RN; Ziegler, RG; Berg, CD; Buys, SS; Haiman, CA; Henderson, BE; Schumacher, FR; Le Marchand, L; Flesch-Janys, D; Lindstrom, S; Hunter, DJ; Hankinson, SE; Willett, WC; Kraft, P; Cox, DG; Khaw, KT; Tjønneland, A; Dossus, L; Trichopoulos, D; Panico, S; Van Gils, CH; Weiderpass, Elisabete; Barricarte, A; Sund, M; Gaudet, MM; Giles, G; Southey, M; Baglietto, L; Chang-Claude, J; Kaaks, R; Canzian, F (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Genome-wide analysis of DNA methylation and gene Expression patterns in purified, uncultures human liver cells and activated hepatic stellate cells 

      Taghdouini, Adil El; Sørensen, Anita Løvstad; Reiner, Andrew Henry; Coll, Mar; Verhulst, Stefaan; Mannaerts, Inge; Øie, Cristina Ionica; Smedsrød, Bård; Najimi, Mustapha; Sokal, Etienne; Luttun, Aernout; Sancho-Bru, Pau; Collas, Philippe; Grunsven, Leo A van (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-31)
      <p>Background & Aims: Liver fibrogenesis – scarring of the liver that can lead to cirrhosis and liver cancer – is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic stellate cell (HSC) activation. To date, the molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. Here, we assess the transcriptome ...

    • A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium 

      McKay, James D.; Truong, Therese; Gaborieau, V; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, G; Zaridze, D; Shangina, O; Szeszenia-Dabrowska, N; Lissowska, Jolanta; Rudnai, P; Fabianova, E; Bucur, A; Bencko, V; Holcatova, I; Janout, V; Foretova, L; Lagiou, Pagona; Trichopoulos, Dimitrios; Benhamou, S; Ahrens, Wolfgang; Bouchardy, C; Merletti, F; Richiardi, L; Talamini, R; Simonato, L; Barzan, L; Kjærheim, Kristina; Macfarlane, G; Agudo, Antonio; Macfarlane, Tatiana V.; Canova, C; Castellsague, X; Conway, DI; Lowry, R; Healy, CM; McKinney, PA; Toner, ME; Znaor, A; Menezes, A; Curado, MP; Koifman, S; Neto, JE; Wünsch-Filho, V; Boccia, S; Arzani, D; Garrote, LF; Cadoni, G; Olshan, AF; Weissler, MC; Luo, JC; Funkhouser, WK; Lubinski, Jan; Lener, M; Trubicka, J; Schwartz, SM; Oszutowska, D; Doody, DR; Chen, C; Fish, S; Lazarus, P; Muscat, JE; Gallagher, CJ; Zhang, Zuo-Feng; Chang, SC; Wei, QY; Sturgis, EM; Franceschi, S; Kelsey, KT; Wang, LE; Herrero, R; Marsit, CJ; McClean, MD; Romkes, M; Nelson, HH; Buch, S; Nukui, T; Zhong, SL; Lacko, M; Manni, JJ; McLaughlin, J; Hung, RJ; Peters, WHM; Vatten, Lars Johan; Njølstad, Inger; Goodman, GE; Field, JK; Palli, D; Liloglou, T; Clavel-Chapelon, F; Vineis, P; Krogh, V; Tumino, R; Panico, S; Martinez, Carmen; Gonzalez, CA; Quiros, JR; Navarro, C; Larranaga, N; Khaw, KT; Ardanaz, E; Key, T; Peeters, PHM; Bueno-De-Mesquita, H. Bas; Boeing, H; Overvad, K; Trichopoulou, A; Linseisen, J; Hallmans, G; Tjønneland, Anne; Riboli, Elio; Kumle, Merethe; Valk, K; Voodern, Tonu; Metspalu, Andres; Boland, A; Zelenika, D; Delepine, M; Foglio, M; Lechner, D; Blanché, Hélène; Gut, Ivo G.; Galan, P; Hashibe, Mia; Heath, Simon; Hayes, Richard B.; Lathrop, Mark; Boffetta, Paolo; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and ...

    • Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura : The emerging Gene Portrait of the Mesothelioma Phenotype 

      Olsen, Karina Standahl; Røe, Oluf Dimitri; Anderssen, Endre; Helge, Eli; Pettersen, Caroline Hild; Sandeck, H; Haaverstad, Rune; Lundgren, Steinar; Larsson, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • The Genomic HyperBrowser: an analysis web server for genome-scale data 

      Sandve, Geir Kjetil; Gundersen, Sveinung; Johansen, Morten; Glad, Ingrid Kristine; Gunathasan, Krishanthi; Holden, Lars; Holden, Marit; Liestøl, Knut; Nygård, Ståle; Nygaard, Vegard; Paulsen, Jonas; Rydbeck, Halfdan; Trengereid, Kai; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Kalaš, Matúš; Lien, Tonje Gulbrandsen; Rye, Morten Beck; Frigessi, Arnoldo; Hovig, Johannes Eivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The immense increase in availability of genomic scale datasets, such as those provided by the ENCODE and Roadmap Epigenomics projects, presents unprecedented opportunities for individual researchers to pose novel falsifiable biological questions. With this opportunity, however, researchers are faced with the challenge of how to best analyze and interpret their genome-scale datasets. A powerful way ...

    • Genomic insights into Enterococcus faecium isolates from marine bivalves highlight One Health concerns and healthcare linkages 

      von Barner Tvedegaard Heim, Amalie; Janice, Jessin; Bjørnholt, Jørgen; Lunestad, Bjørn Tore; Hegstad, Kristin; Svanevik, Cecilie Smith (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-12)
      Enterococci, especially Enterococcus faecium, are one of today’s leading causes of multidrug-resistant infections in hospital settings. The marine environment may harbour enterococci, but its role as an evolutionary niche and as a vector for the spread of enterococci is sparsely investigated. Hence, by applying enterococci in bivalves as a sentinel tool, this study aimed to describe the prevalence ...

    • Genomic Sequencing and Phylogenomics of Cowpox Virus 

      Diaz Cánova, Diana Karina; Mavian, Carla; Brinkmann, Annika; Nitsche, Andreas; Moens, Ugo; Okeke, Malachy Ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      <i>Cowpox virus</i> (CPXV; genus <i>Orthopoxvirus</i>; family <i>Poxviridae</i>) is the causative agent of cowpox, a self-limiting zoonotic infection. CPXV is endemic in Eurasia, and human CPXV infections are associated with exposure to infected animals. In the Fennoscandian region, five CPXVs isolated from cats and humans were collected and used in this study. We report the complete sequence of ...

    • Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density 

      Gram, Inger Torhild; Biong, M; Brill, I; Bremnes, Yngve; Johansen, F; Solvang, Hiroko Kato; Alnaes, GIG; Fagerheim, Toril; Chanock, Stephen; Burdett, L; Yeager, M; Ursin, Giske; Kristensen, Vessela N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Giant group I intron in a mitochondrial genome is removed by RNA back-splicing 

      Chi, Sylvia Ighem; Dahl, Mikael; Emblem, Åse; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
      <p><i>Background - </i>The mitochondrial genomes of mushroom corals (Corallimorpharia) are remarkable for harboring two complex group I introns; ND5-717 and COI-884. How these autocatalytic RNA elements interfere with mitochondrial RNA processing is currently not known. Here, we report experimental support for unconventional processing events of ND5-717 containing RNA. <p><i>Results - </i>We obtained ...

    • The global dissemination of hospital clones of Enterococcus faecium 

      van Hal, Sebastiaan J.; Willems, Rob J.L.; Gouliouris, Theodore; Ballard, Susan A.; Coque, Teresa M.; Hammerum, Anette M.; Hegstad, Kristin; Westh, Henrik; Howden, Benjamin P.; Malhotra-Kumar, Surbhi; Werner, Guido; Yanagihara, Katsunori; Earl, Ashlee M.; Raven, Katherine E.; Corander, Jukka; Bowden, Rory (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-30)
      <i>Background</i> - The hospital-adapted A1 group of <i>Enterococcus faecium</i> remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.<br><br> <i>Methods</i> - A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of ...

    • Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis 

      Tveita, Anders Aune; Rekvig, Ole Petter; Zykova, Svetlana N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-01)
      Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex deposition. It has been speculated that alterations in the synthesis or ...

    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Introduction - </i>Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer ...

    • GPs' decision-making - perceiving the patient as a person or a disease 

      Andre, M; Anden, A; Borgquist, L; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background: The aim of this study was to analyse the clinical decision making strategies of GPs with regard to the whole range of problems encountered in everyday work. Methods: A prospective questionnaire study was carried through, where 16 General practitioners in Sweden registered consecutively 378 problems in 366 patients. Results: 68.3% of the problems were registered as somatic, 5.8% as ...

    • Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better? 

      Steigen, Sonja E; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela-Elena; Johannessen, Anne Christine; Jebsen, Peter Wilhelm; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-03)
      <i>Background</i> - Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring system should be robust and well validated, and intra‐ and interrater agreement can be used as a tool to visualize the strength of reproducibility.<p><p> <i>Methods</i> ...

    • Grazing incidence to total internal reflection fluorescence structured illumination microscopy enabled by a prism telescope 

      Ortkrass, Henning; Wiebusch, Gerd; Linnenbrügger, Jochen; Schürstedt, Jasmin; Szafranska, Karolina Joanna; McCourt, Peter Anthony; Huser, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-13)
      In super-resolution structured illumination microscopy (SR-SIM) the separation between opposing laser spots in the back focal plane of the objective lens affects the pattern periodicity, and, thus, the resulting spatial resolution. Here, we introduce a novel hexagonal prism telescope which allows us to seamlessly change the separation between parallel laser beams for 3 pairs of beams, simultaneously. ...

    • Guidelines on models of diabetic heart disease 

      Heather, Lisa C.; Hafstad, Anne Dragøy; Halade, Ganesh V.; Harmancey, Romain; Mellor, Kimberley M.; Mishra, Paras K.; Mulvihill, Erin E.; Nabben, Miranda; Nakamura, Michinari; Rider, Oliver J.; Ruiz, Matthieu; Wende, Adam R.; Ussher, John R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-08)
      Diabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact ...

    • Gule stafylokokker hos barn 

      Simonsen, Gunnar Skov (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Antibiotikastyring er et av de viktigste tiltakene mot resistensutvikling. Ved hud- og bløtdelsinfeksjoner hos barn skal vi fortsatt ha en nøktern forskrivningspraksis.

    • Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo 

      Liu, Yinhui; Song, Xiaobo; Zhou, Huimin; Zhou, Xue; Xia, Yunlong; Dong, Xin; Zhong, Wei; Tang, Shaoying; Wang, Lili; Wen, Shu; Xiao, Jing; Tang, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species abundance of gut microbiome in association with rosuvastatin efficacy. <br> <br> TRIAL REGISTRATION: ChiCTR-ORC-17013212 at the First Affiliated Hospital ...