Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

Viser treff 441-460 av 1054

    • Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5) 

      Lindin, Inger; Wuxiuer, Yimingjiang; Kufareva, Irina; Abagyan, Ruben; Moens, Ugo; Sylte, Ingebrigt; Ravna, Aina Westrheim (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the groups of Houng Ni and Ligou New, and was found to be highly conserved throughout the vertebrates. Studies, both in vivo and in vitro, have shown that it is implicated in tumor ...

    • Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy 

      Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer protoporphyrin IX (PpIX). Activation of PpIX by light causes the formation of reactive oxygen species (ROS) and toxic responses. Studies have indicated that ...

    • Homology Modeling of Transporter Proteins 

      Sylte, Ingebrigt; Gabrielsen, Mari; Kristiansen, kurt (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological importance. Several presently used therapeutic compounds elucidate their effects by targeting membrane transporter proteins, including anti-arrhythmic, anesthetic, antidepressant, anxiolytic and diuretic drugs. The lack of three-dimensional structures of ...

    • Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus) 

      Mortensen, Åse-Karen; Mæhre, Silje; Kristiansen, kurt; Heimstad, Eldbjørg Sofie; Gabrielsen, Geir W.; Jenssen, Bjørn Munro; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-11)
      Thyroid hormone disrupting chemicals (THDCs) are of major concern in ecotoxicology. With the increased number of emerging chemicals on the market there is a need to screen for potential THDCs in a cost-efficient way, and <i>in silico</i> modeling is an alternative to address this issue. In this study homology modeling and docking was used to screen a list of 626 compounds for potential thyroid hormone ...

    • Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania 

      Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; Janice, Jessin; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the <i>bla</i><sub>CTX-M-15</sub> extended-spectrum-β-lactamase (ESBL) gene in <i>Klebsiella pneumoniae</i> isolates obtained from stool samples from hospitalized children and healthy controls ...

    • Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis 

      Waaseth, Marit; Bakken, Kjersti; Dumeaux, Vanessa; Olsen, Karina Standahl; Rylander, Charlotta; Figenschaug, Yngve; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-14)
      Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: ...

    • Host and microbe determinants that may influence the success of S. aureus colonization 

      Johannessen, Mona; Sollid, Johanna U Ericson; Hanssen, Anne-Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Staphylococcus aureus may cause serious skin and soft tissue infections, deep abscesses, endocarditis, osteomyelitis, pneumonia, and sepsis. S. aureus persistently colonizes 25–30% of the adult human population, and S. aureus carriers have an increased risk for infections caused by the bacterium. The major site of colonization is the nose, i.e., the vestibulum nasi, which is covered with ordinary ...

    • How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy 

      Hafstad, Anne Dragøy; Boardman, Neoma Tove; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-28)
      Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of development of cardiovascular disorders. Diabetic cardiomyopathy, independent of hypertension or coronary disease, is induced by a range of systemic changes and may through multiple processes result in functional and ...

    • HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy 

      Sørbye, Sveinung Wergeland; Arbyn, Marc; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage ...

    • HPV mRNA is more specific than HPV DNA in triage of women with minor cervical lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18)
      311 women were scheduled for triage of minor cervical lesions (ASC-US / LSIL). 30 women (9.6%) had ASC-H/HSIL cytology at triage and 281 women (90.4%) had ASC-US/LSIL or normal cytology. The HPV DNA test was positive in 92 (32.7%) of 281 instances, and 37 (13.2%) were mRNA positive. Of the 132 women with repeated ASC-US/LSIL, we received biopsies from 97.0% (65/67) of the DNA-positive and 92.9% ...

    • HPV mRNA test in primry screening of women 20-34 years 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2011)

    • HPV mRNA test in women with minor cervical lesions : experience of the University Hospital of North Norway 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      In the Norwegian Cervical Cancer Screening Programme tests for detection of human papillomavirus (HPV) are used to triage women with minor cytological cervical lesions. The material in this study comprises samples from 1798 women in the period 2006–2008. The HPV test was performed according to the guidelines of the Norwegian Cancer Registry. The HPV mRNA test (PreTect HPV-Proofer) detects and types ...

    • HPV mRNA testing in triage of women with ASC-US cytology may reduce the time for CIN2+ diagnosis compared with repeat cytology. 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: In delayed HPV triage women with atypical squamous cells of uncertain significance (ASC-US) cytology are retested after 6-12 months in order to decide whether they should be referred for colposcopy, further follow-up cytology or routine screening in three years. Triage using a specific HPV E6/E7 mRNA test may reduce referrals for colposcopy of women with ASC-US cytology compared to HPV ...

    • HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2013)
      In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ...

    • HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda : a case-control study 

      Odida, M; Sandin, S; Mirembe, F; Kleter, B; Quint, W; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      While the association of human papillomavirus (HPV) with cervical cancer is well established, the influence of HIV on the risk of this disease in sub-Saharan Africa remains unclear. To assess the risk of invasive cervical carcinoma (ICC) associated with HIV and HPV types, a hospital-based case-control study was performed between September 2004 and December 2006 in Kampala, Uganda. Incident cases of ...

    • Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin 21-157 

      Berg, Vivian; Sveinbjørnsson, Baldur; Bendiksen, Signy; Brox, Jan; Meknas, Khaled; Figenschau, Yngve (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Chemerin is a chemotactic peptide which directs leukocytes expressing the chemokine-like receptor ChemR23 towards sites of inflammation. ChemR23 is a G protein-coupled receptor which binds several different ligands, and it is also expressed by other cell types such as adipocytes. In addition to chemotaxis, recent reports suggest that ChemR23 is capable of mediating either inflammatory or anti-inflammatory ...

    • Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress 

      Boardman, Neoma Tove; Falck, Aleksander Tank; Lund, Trine; Chu, X; Martin, Armas Maria Montserrat; Norvik, Jon Viljar; Jenssen, Trond Geir; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-14)
      Uric acid is a purine degradation product but also an important antioxidant and ROS scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on ...

    • Human endogenous retroviruses and cancer prevention: evidence and prospects 

      Cegolon, Luca; Salata, Cristiano; Weiderpass, Elisabete; Vineis, Paolo; Palu, Giorgio; Mastrangelo, Giuseppe (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers ...

    • Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation 

      Paulsen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-02)
      The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other organisms. However, bioinformatics imply that 2OG-dependent prolyl-hydroxylases (PHDs) homologous to those acting as sensing components for the HIF system ...

    • Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ...