Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

Viser treff 909-928 av 1054

    • Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA 

      Birgisdottir, Åsa Birna; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2005)
      The myxomycete Didymium iridis (isolate Panama 2) contains a mobile group I intron named Dir.S956-1 after position 956 in the nuclear small subunit (SSU) rRNA gene. The intron is efficiently spread through homing by the intron-encoded homing endonuclease I-DirI. Homing endonuclease genes (HEGs) usually spread with their associated introns as a unit, but infrequently also spread independent ...

    • SLE classification criteria: Is “The causality principle” integrated and operative – and do the molecular and genetical network, on which criteria depend on, support the definition of SLE as “a one disease entity” – A theoretical discussion 

      Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-24)
      Molecular and cellular aspects of the autoimmune pathophysiology in SLE is linked to the “The causality principle”. SLE Classification Criteria identify per definition disease measures (here: synonymous with classification criteria), but not diagnostic criteria within a classical framework. These two mostly theoretical criteria collections represent a salient conflict between phenomenology and the ...

    • SLE classification criteria: Science-based icons or algorithmic distractions – an intellectually demanding dilemma 

      Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      It is, so to say, not a prerogative authority assigned to SLE classification criteria that allow them to declare something definitively important about SLE. This is particularly true as criteria-based classification processes overrule the highly needed evolution of concise diagnostic criteria. It is classification criteria that allocate SLE patients into cohorts intended to describe the nature of ...

    • The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes 

      Csoboz, Balint; Gombos, Imre; Kóta, Zoltán; Dukic, Barbara; Klement, Éva; Varga-Zsíros, Vanda; Lipinszki, Zoltán; Páli, Tibor; Vígh, László; Török, Zsolt (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a major sHSP in mammals, but its lipid interaction profile has so far been unexplored. In this study, we characterized the interaction between HSPB1 and phospholipids. ...

    • Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells 

      Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Lindin, Inger; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mechanisms and have been shown to induce a protective immune response against solid tumors, thus making them interesting candidates for developing novel lead structures for anticancer treatment. ...

    • Smoking duration before first childbirth: an emerging risk factor for breast cancer? Results from 302,865 Norwegian women 

      Bjerkaas, Eivind; Parajuli, Ranjan; Weiderpass, Elisabete; Engeland, Anders; Gertraud, Maskarinec; Selmer, Randi; Gram, Inger Torhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Purpose: Recently, The International Agency for Research on Cancer classified cigarette smoking as possibly carcinogenic to the human breast. Since some new cohort studies have suggested that this risk is confined to women who started to smoke before first childbirth, we wanted to examine the association between smoking and breast cancer, with a focus on time of smoking initiation in relation to the ...

    • Social Inequalities and Mortality in Europe - Results from a Large Multi-National Cohort 

      Gallo, Valentina; Mackenbach, Johan P.; Ezzati, Majid; Menvielle, Gwenn; Kunst, Anton E.; Rohrmann, Sabine; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Tjønneland, Anne; Dalton, Susanne O.; Overvad, Kim; Redondo, Maria Luisa; Agudo, Antonio; Daponte, Antonio; Arriola, Larraitz; Navarro, Camen; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Wareham, Nick; Key, Tim; Naska, Androniki; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Masala, Giovanna; Panico, Salvatore; Contiero, Paolo; Tumino, Rosario; Bueno-de-Mesquita, H. Bas; Siersema, Peter D.; Peeters, Petra P. H.; Zackrisson, Sophia; Almquist, Martin; Eriksson, Sture; Hallmans, Göran; Skeie, Guri; Braaten, Tonje; Lund, Eiliv; Illner, Anne-Kathrin; Mouw, Traci; Riboli, Elio; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and ...

    • Socio-demographic Characteristics of Suicides in the Nenets Autonomous Okrug, Northwestern Russia. 

      Sumarokov, Yury; Brenn, Tormod; Kudryavtsev, Alexander Valerievich; Nilssen, Odd (Conference object; Konferansebidrag, 2015-03-28)

    • Socio-economic inequalities in health care utilisation in Norway: a population based cross-sectional survey 

      Hansen, Anne Helen; Halvorsen, Peder Andreas; Ringberg, Unni; Førde, Olav Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Norway provides universal health care coverage to all residents, but socio-economic inequalities in health are among the largest in Europe. Evidence on inequalities in health care utilisation is sparse, and the aim of this population based study was to investigate socio-economic inequalities in the utilisation of health care services in Troms[latin small letter o with stroke], Norway.

    • Socioeconomic status and risk of incident venous thromboembolism 

      Jørgensen, Helle; Horváth-Puhó, Erzsébet; Laugesen, Kristina; Brækkan, Sigrid; Hansen, John-Bjarne; Sørensen, Henrik Toft (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-09)
      Background: Although venous thromboembolism (VTE) is a leading cause of morbidity and mortality, and socioeconomic status (SES) affects human health and health behavior, few studies have examined the association between SES and VTE. Objectives: We aimed to investigate the association between SES, assessed individually and in a composite score by levels of education, income, and employment status, and ...

    • Sodium nitroprusside inhibits HEK293 cell growth by cGMP-dependent and independent mechanisms 

      Sager, Georg; Sundkvist, Elisabeth; Jæger, Ragnhild; Lyså, Roy Andre; Fuskevåg, Ole-Martin; Fuskevåg, Ole-Martin (Journal article; Tidsskriftartikkel, 2014)

    • The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor. 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-24)
      Cellular stress response mechanisms typically increase organellar quantity and volume. To restore cellular homeostasis and organellar integrity, the surplus organelles are cleared by macroautophagy/autophagy, an intracellular process that shuttles cytoplasmic material to the lysosomes for degradation. The degradation is mediated by autophagy receptors that selectively link the degradable cargo to ...

    • Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC 

      Caboux, Elodie; Lallemand, Christophe; Ferro, Gilles; Hemon, Bertrand; Mendy, Maimuna; Biessy, Carine; Sims, Matt; Wareham, Nicholas; Britten, Abigail; Boland, Anne; Hutchinson, Amy; Siddiq, Afshan; Vineis, Paolo; Riboli, Elio; Romieu, Isabelle; Rinaldi, Sabina; Gunter, Mark J.; Peeters, Petra H.M.; van der Schouw, Yvonne T.; Travis, Ruth C.; Bueno-De-Mesquita, H. Bas; Canzian, Federico; Sanchez, Maria-José; Skeie, Guri; Olsen, Karina Standahl; Lund, Eiliv; Bilbao, Roberto; Sala, Núria; Barricarte, Aurelio; Palli, Domenico; Navarro, Carmen; Panico, Salvatore; Redondo, Maria Luisa; Polidoro, Silvia; Dossus, Laure; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Boeing, Heiner; Fisher, Eva; Tumino, Rosario; Agnoli, Claudia; Hainaut, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer and nutrition. This study has served as a basis for a number of Genome-Wide Association Studies (GWAS) and other types of genetic analyses. Over a period of 5 years, 52,256 EPIC DNA samples have been extracted using an automated ...

    • Soy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2 

      Jacobsen, Bjarne Koster; Jaceldo-Siegl, Karen; Knutsen, Synnøve Fønnebø; Fan, Jing; Oda, Keiji; Fraser, Gary E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Objectives: As little is known about the possible relationship between the intake of phytoestrogens and female fertility, we investigated the relationship between soy isoflavone intake and the risk of nulliparity and nulligravidity. Methods: A cross-sectional study of 11,688 North American Adventist women aged 30–50 years old with data regarding childbearing. These women were, as a group, characterized ...

    • Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI 

      Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck; Giskeødegård, Guro F.; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-29)
      Background - Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was therefore to spatially detect metabolites and lipids on prostate tissue sections by using mass spectrometry imaging (MSI), a method that facilitates molecular imaging of heterogeneous ...

    • SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1 

      Darvekar, Sagar; Elvenes, Julianne; Brenne, Hanne; Johansen, Terje; Sjøttem, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Specific interactions between the alkaline protease of P. aeruginosa and its natural peptide inhibitor: ab initio molecular simulations 

      Saito, Ryosuke; Imai, Kyohei; Yamamoto, Shohei; Ezawa, Takuya; Sugiyama, Satohsi; Evenseth, Linn; Sylte, Ingebrigt; Kurita, Noriyuki (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Alkaline protease aeruginolysin (APR) is an important virulence factor in the evasion of the immune system by Pseudomonas aeruginosa (P. aeruginosa). The P. aeruginosa genome also encodes the highly potent and specifc APR peptide inhibitor (APRin). However, the structural reason for the signifcant inhibition has not been revealed. Using ab initio molecular simulations, we here investigated the ...

    • SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function 

      Schwob, Aurélien; Teruel, Elodie; Dubuisson, Louise; Lormières, Florence; Verlhac, Pauline; Abudu, Yakubu Princely; Gauthier, Janelle; Naoumenko, Marie; Cloarec-Ung, Fanny-Meï; Faure, Mathias; Johansen, Terje; Dutartre, Hélène; Mahieux, Renaud; Journo, Chloé (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the ubiquitin-rich IKK complex. We previously demonstrated that Optineurin and TAX1BP1, two members of the ubiquitin-binding, Sequestosome-1 (SQSTM-1/p62)-like selective ...

    • SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair 

      Hewitt, Graeme; Carroll, Bernadette; Sarallah, Rezazadeh; Correia-Melo, Clara; Ogrodnik, Mikolaj; Nelson, Glyn; Otten, Elsje G; Manni, Diego; Antrobus, Robin; Morgan, Brian A; von Zglinicki, Thomas; Jurk, Diana; Seluanov, Andrei; Gorbunova, Vera; Johansen, Terje; Passos, João F; Korolchuk, Viktor I (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)
      SQSTM1/p62 (sequestosome 1) selectively targets polyubiquitinated proteins for degradation via macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the cytoplasmic and nuclear compartments, although its role in the nucleus is relatively unknown. Here, we report that SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair. Upon induction of DNA damage ...

    • Standardization meets stories: contrasting perspectives on the needs of frail individuals at a rehabilitation unit 

      Mjølstad, Bente Prytz; Kirkengen, Anna Luise; Getz, Linn; Hetlevik, Irene (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Repeated encounters over time enable general practitioners (GPs) to accumulate biomedical and biographical knowledge about their patients. A growing body of evidence documenting the medical relevance of lifetime experiences indicates that health personnel ought to appraise this type of knowledge and consider how to incorporate it into their treatment of patients. In order to explore ...