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norskArtikler, rapporter og annet (medisinsk biologi): Recent submissions
Now showing items 1061-1080 of 1105
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Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of Angiotensin II
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Homeopati og bivirkninger
(Chronicle; Kronikk, 2010) -
Dairy consumption and calcium intake and risk of breast cancer in a prospective cohort : The Norwegian Women and Cancer study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Recruitment methods in Alzheimer's disease research : general practice versus population based screening by mail
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Understanding unexpected courses of multiple sclerosis among patients using complementary and alternative medicine : A travel from recipient to explorer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa - a literature review and focus group study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Effect of Unfractionated Heparin on TFPI Elimination
(Journal article; Tidsskriftartikkel, 2010)Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ... -
Asialoglycoprotein Receptor (ASGP-R) is Liver Parenchymal Cells is Involved in Elimination of Recombinant Human TFPI
(Journal article; Tidsskriftartikkel, 2010)We here report on a study carried out to determine the early clearance kinetics, and organ, cell(s) and receptor(s) responsible for the clearance of full length TFPI purified from BHK cells (TFPI<sup>BHK</sup>). Following intravenous administration, <sup>125</sup>I-TFPI<sup>BHK</sup> was cleared with a biphasic elimination curve, and with a significantly slower t<sub>1/2</sub>α compared to recombinant ... -
Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis
(Tidsskriftartikkel; Peer reviewed; Journal article, 2010-08-10)Background: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice. As this may represent a basic mechanism in the progression of lupus nephritis, several aspects of ... -
Prognostic Impact of Fibroblast Growth Factor 2 in NSCLC : Co-Expression with VEGFR-3 and PDGF-B Predicts Poor Survival
(Tidsskriftartikkel; Peer reviewed; Journal article, 2009-05)Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis. Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact ... -
Silencing Viral MicroRNA as a Novel Antiviral Therapy?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-03-20)Viruses are intracellular parasites that ensure their existence by converting host cells into viral particle producing entities or into hiding places rendering the virus invisible to the host immune system. Some viruses may also survive by transforming the infected cell into an immortal tumour cell. MicroRNAs are small non-coding transcripts that function as posttranscriptional regulators of gene ... -
Matrix metalloproteinases in subjects with type 1 diabetes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-16)Background: Nephropathy is serious complication of diabetes. We have previously shown that level of the proteoglycan syndecan-1 in blood is associated with ultrastructural kidney changes in young persons with type 1 diabetes. Dysregulation of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) may contribute to the development of nephropathy. The aim of ... -
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-04)The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of <i>Escherichia coli</i> MsbA, which were constructed in order to elucidate differences in the electrostatic and molecular features of their drug ... -
In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ... -
The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-06-15)Background: Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We have previously shown that CAPs interact with the two glycosaminoglycans (GAGs), ... -
Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)Introduction: Acute lung injury often complicates severe sepsis. In Gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human ... -
Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-01)Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex deposition. It has been speculated that alterations in the synthesis or ...
