Blar i tittel Artikler, rapporter og annet (klinisk medisin)

Viser treff 802-821 av 1796

    • The Impact of Cytokines on the Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus 

      Raymond, Warren David; Eilertsen, Gro Østli; Shanmugakumar, Sharanyaa; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-15)
      <i>Introduction</i>: Systemic lupus erythematosus (SLE) reduces the health-related quality of life (HRQoL), even during periods of disease quiescence. We investigated whether subclinical inflammation as reflected by cytokine levels is linked with reduced HRQoL. Methods: A cross-sectional study of SLE patients (<i>n</i> = 52, mean age 47.3, 86.5% female) who completed a Short Form Health Survey-36 ...

    • The impact of gender, puberty, and pregnancy in patients with POLG disease 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Samsonsen, Christian; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Rene; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-18)
      <i>Objective</i> - To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known.<p> <p><i>Methods</i> - Clinical, laboratory, and genetic data were collected retrospectively from 155 patients with genetically confirmed POLG disease recruited from seven European countries. We used the available data to study the impact ...

    • Impact of helicopter emergency medical services in major incidents: systematic literature review 

      Johnsen, Anne Siri; Fattah, Sabina; Sollid, Stephen; Rehn, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Introduction: Helicopter emergency medical services (HEMS) aim to bring highly specialised crews to the major incident for triage, treatment and transport. When the site is difficult to access, HEMS may be the only mode of transportation of both personnel and patients. This systematic review will identify, describe and appraise literature regarding the role of HEMS in medical response to major ...

    • Impact of hidradenitis suppurativa on work loss, indirect costs and income 

      Tzellos, Thrasyvoulos; Yang, H; Mu, F; Calimlim, B; Signorovitch, J (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-18)
      Background Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life. Objectives This retrospective cohort study evaluates the indirect burden among employed patients with HS in the U.S.A.<p> <p>Methods Newly diagnosed and general patients with HS, who were employees (age 18–64 years) from a large claims database (Q1 1999 to Q1 2015), were matched 1 : 5 to ...

    • Impact of Illness on Electronic Health Use (The Seventh Tromsø Study - Part 2): Population-Based Questionnaire Study 

      Ruiz, Luis Marco; Wynn, Rolf; Oyeyemi, Sunday Oluwafemi; Budrionis, Andrius; Yigzaw, Kassaye Yitbarek; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)
      <p><i>Background:</i> Patients who suffer from different diseases may use different electronic health (eHealth) resources. Thus, those who plan eHealth interventions should take into account which eHealth resources are used most frequently by patients that suffer from different diseases. <p><i>Objective:</i> The aim of this study was to understand the associations between different groups of chronic ...

    • The impact of implementing patient-reported measures in routine maternity care: a systematic review 

      Chen, An; Väyrynen, Kirsi; Schmidt, Alexandra; Leskelä, Riikka-Leena; Torkki, Paulus; Heinonen, Seppo; Tekay, Aydin; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      Introduction While there is growing interest in applying patient-reported measures (PRMs) in clinical routine, limited collective evidence of the impact of PRMs hinder their widespread use in specific contexts, such as maternity care. Our objective was to synthesize existing emperical evidence on the impact of implementing PRMs in routine maternity care. Material and methods We followed the ...

    • Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study 

      Balteskard Rinde, Ludvig; Lind, Caroline; Småbrekke, Birgit; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Løchen, Maja-Lisa; Mathiesen Hald, Erin; Vik, Anders; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Rinde, Ludvig Balteskard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. <p> Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. <p> Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 ...

    • Impact of incident venous thromboembolism on risk of arterial thrombotic diseases 

      Lind, Caroline; Flinterman, Linda E.; Enga, Kristin; Severinsen, Marianne T; Kristensen, Søren R; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Cannegieter, Suzanne C.; Overvad, Kim; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-22)
      BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND ...

    • Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations 

      Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne; Kringen, Marianne K.; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Background: There is limited knowledge on the causes of large variations in serum methadone concentrations and dose requirements. Objectives: We investigated the impact of the degree of liver fibrosis on dose-adjusted steady-state serum methadone concentrations.<p> <p<Methods: We assessed the clinical and laboratory data of 155 Norwegian patients with opioid use disorder undergoing methadone ...

    • Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Lombardi, Ana Paola; Pøhl, Mette; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Pezzella, Francesco; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ...

    • Impact of multi-professional, scenario-based training on postpartum hemorrhage in Tanzania: A quasi-experimental, pre- vs. post-intervention study 

      Egenberg, Signe; Masenga, Gileard; Bru, Lars Edvin; Eggebø, Torbjørn Moe; Mushi, Cecilia; Massay, Deodatus Amadeus; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-05)
      Background: <br> Tanzania has a relatively high maternal mortality ratio of 410 per 100,000 live births. Severe postpartum hemorrhage (PPH) is a major cause of maternal deaths, but in most cases, it is preventable. However, most pregnant women that develop PPH, have no known risk factors. Therefore, preventive measures must be offered to all pregnant women. This study investigated the effects ...

    • The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model 

      Florholmen-Kjær, Åse; Goll, Rasmus; Fuskevåg, Ole-Martin; Nygård, Ingvild; Paulssen, Ruth H; Revhaug, Arthur; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-24)
      Background Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post-PHx, utilizing an analytical platform more sensitive and precise than earlier ...

    • Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis 

      Jamaly, Simin; Ramberg, Cathrine; Olsen, Randi; Latysheva, Nadezhda; Webster, Paul; Sovershaev, Timofey; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ...

    • Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Evensen, Line Holtet; Morelli, Vania Maris; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Njølstad, Inger; Mathiesen, Ellisiv B.; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...

    • Impact of red cell distribution width on future risk of cancer and all-cause mortality among cancer patients – the Tromsø Study 

      Ellingsen, Trygve; Lappegård, Jostein; Skjelbakken, Tove; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10)

    • Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. 

      Børvik, Trond; Evensen, Line; Morelli, Vania Maris; Melbye, Hasse; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
      Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO<sub>2</sub>), individually and in combination with COPD, affect the risk of VTE.<p> <p> Objectives: To investigate whether measures of respiratory impairments including respiratory symptoms ...

    • Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-01)
      Background - von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the risk of future venous thromboembolism (VTE) is unknown.<p> <p>Objectives - To investigate whether plasma ADAMTS-13 levels and an imbalance with VWF levels, assessed as the VWF/ADAMTS-13 ratio, are associated with the risk ...

    • Impact on patient-provider relationship and documentation practices when mental health patients access their electronic health records online: a qualitative study among health professionals in an outpatient setting 

      Zanaboni, Paolo; Kristiansen, Eli; Lintvedt, Ove; Wynn, Rolf; Johansen, Monika Alise; Sørensen, Tove; Fagerlund, Asbjørn Johansen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)
      Background - Patient accessible electronic health records (PAEHR) hold the potential to increase patient empowerment, especially for patients with complex, long-term or chronic conditions. However, evidence of its benefits for patients who undergo mental health treatment is unclear and inconsistent, and several concerns towards use of PAEHR emerged among health professionals. This study aimed at ...

    • Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population 

      Melsom, Toralf; Mathisen, Ulla Dorte; Ingebretsen, Ole C; Jenssen, Trond Geir; Njølstad, Inger; Solbu, Marit Dahl; Toft, Ingrid; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...

    • Implementation of international society guidelines on chorionicity determination in twins: A multi-Center cohort study in mainland China 

      Wu, Su-Wen; Zhou, Qiongjie; Xiao, Xirong; Xiong, Yu; Liang, Huan; Shen, Jie; Barrett, Jon; Wang, Hong; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      Objective: Ultrasound determination of chorionicity is poor in early pregnancy in China. In an effort to increase the accuracy rate of prompt chorionicity determination, clinical training was provided to primary care physicians. This study assesses the effects of implementing clinical guidelines on chorionicity determination.<p> <p>Methods: A multi‑centered cohort study was conducted between ...