Artikler, rapporter og annet (klinisk medisin): Nye registreringer
Viser treff 901-920 av 1806
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Factors influencing growth of children aged 12-24 months in the Tanga Region, Tanzania
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)<i>Background</i> - The first 1000 days of life, from conception to the second birthday, offer a unique window of opportunity for optimal growth, critical for future health. The primary aim of this study was to analyze growth of children between 12 and 24 months age in Tanzanian children, and to explore possible predictors for growth.<p> <p><i>Methods</i> - Observational, cross-sectional study ... -
Growth and neurodevelopment in very preterm infants receiving a high enteral volume-feeding regimen - a population-based cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-06)<i>Aim</i>: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment.<p> <p><i>Method</i>: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005–2010. ... -
The Maternal and Paternal Effects on Clinically and Surgically Defined Osteoarthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)<i>Objective</i> - It is currently unknown whether osteoarthritis (OA) is inherited mainly from the mother, father, or both. This study was undertaken to explore the effect of maternal and paternal factors on hip, knee, and hand OA in offspring.<p> <p><i>Methods</i> - Participants from the Musculoskeletal Pain in Ullensaker Study (MUST) (69% female; mean ± SD age 64 ± 9 years) and a Norwegian ... -
Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-<i>tert</i>-butylphenyl)-4-piperazinyl-benzimidazole scaffold <i>via</i> Cu-catalysed azide alkyne cycloaddition. Our main purpose was to find a more soluble compound based on the WAY207024 lead with nanomolar potency ... -
Ambulatory vocal acoustics, temporal dynamics, and serious mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019)Acoustic analysis of vocal expression offers a potentially inexpensive, unobtrusive, and highly sensitive biobehavioral measure of serious mental illness (SMI)-related issues. Despite literature documenting its use for understanding SMI, prior studies have largely ignored that vocal expression is highly dynamic within individuals over time. We employed ambulatory vocal assessment from SMI outpatients ... -
Smoking and other determinants of bone turnover
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)The balance between bone resorption and formation may be assessed by measurement of bone turnover markers (BTMs), like carboxyl-terminal cross-linked telopeptide of type 1 collagen (CTX-1) and procollagen type 1 amino-terminal propeptide (P1NP). Smoking has been shown to influence bone turnover and to reduce bone mass density (BMD), the exact mechanism for this is, however, not settled. In this ... -
What is currently the best investigational approach to the patient with sudden-onset severe headache?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)<i>Presentation of Case</i> – Ane Skaare Sjulstad, MD, Adult Neurology Resident, Nordland Hospital, Bodø, Norway A 48‐year‐old man with no previous medical history suddenly experienced severe intense retro‐bulbar pain of pulsating character on the right side, and was seen in the emergency department 7 hours later. He was then alert and oriented, but in excruciating pain. There was no neck stiffness ... -
Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)<i>Main objective</i> - The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at ... -
Caffeine and primary (migraine) headaches-friend or foe?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)<i>Background</i>: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. Caffeine influences headaches, the migraine syndrome in particular, but how is unclear.<p> <p><i>Materials and Methods</i>: This is a narrative ... -
Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-31)<p><i>Background - </i>Diabetic nephropathy is the most common cause of end‐stage renal failure in the western world and Asia. The mechanisms are not fully elucidated, but disruption of glomerular endothelial glycocalyx and shedding of its components including syndecans has been implicated. <p><i>Aims - </i>We hypothesize that reduced glomerular filtration in diabetes is caused by disruption of ... -
Updating verbal fluency analysis for the 21st century: Applications for psychiatry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-07)Evaluating patients’ verbal fluency by counting the number of unique words (e.g., animals) produced in a short-period (e.g., 1–3 min) is one of the most widely employed cognitive tests in psychiatric research. We introduce new methods to analyze fluency output that leverage modern computational language technology. This enables moving beyond simple word counts to charting the temporal dynamics of ... -
A large-scale exome array analysis of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-19)Although recent Genome‐Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome‐wide search for low‐frequency variants that affect the risk of venous thromboembolism (VTE). We conducted a meta‐analysis of 11 studies comprising 8,332 cases and 16,087 controls of European ancestry and 382 cases and 1,476 controls of African American ancestry ... -
Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood
(Journal article; Tidsskriftartikkel, 2019-07-25)<i>Aim</i> - To study the role of complement receptor 1 (CR1) for binding of <i>Escherichia coli (E. coli)</i> to erythrocytes, for leukocyte phagocytosis, oxidative burst and complement activation in human whole blood from a CR1 deficient (CR1D) patient and healthy controls with low, medium and high CR1 numbers.<p> <p><i>Methods</i> - Alexa-labelled bacteria were used to quantify ... -
Maternal cardiac function, uterine artery hemodynamics and natriuretic peptides at 22-24 weeks of gestation and subsequent development of hypertensive disorders of pregnancy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-26)<p><i>Introduction - </i>Maternal cardiac dysfunction as well as abnormal uterine artery (UtA) Doppler are associated with hypertensive disorders of pregnancy (HDP), but their relation is unclear. We investigated the correlation between maternal cardiac function, UtA hemodynamics and natriuretic peptides, and explored differences between women who subsequently developed HDP and those who did ... -
Automated analysis of fetal cardiac function using color tissue Doppler imaging in second half of normal pregnancy
(Journal article; Tidsskriftartikkel, 2018-02-26)<i>Objectives</i> - Color tissue Doppler imaging (cTDI) is a promising tool for the assessment of fetal cardiac function. However, the analysis of myocardial velocity traces is cumbersome and time‐consuming, limiting its application in clinical practice. The aim of this study was to evaluate fetal cardiac function during the second half of pregnancy and to develop reference ranges using an ... -
Explaining the association between anxiety disorders and alcohol use disorder: A twin study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)<p><i>Background - </i>It is unknown whether social anxiety disorder (SAD) has a unique association with alcohol use disorder (AUD) over and beyond that of other anxiety disorders, how the associations develop over time, and whether the associations are likely to be causal. <p><i>Methods - </i>Diagnoses of AUD, SAD, generalized anxiety disorder, panic disorder, agoraphobia, and specific phobias ... -
Characteristics of women with chronic pelvic pain referred to physiotherapy treatment after multidisciplinary assessment: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-31)<i>Background and aims</i> - Chronic pelvic pain (CPP) in women is a complex condition that can seriously impact health and quality of life. Clinical guidelines for CPP place great demands on healthcare professionals, as they require both specialized knowledge about the pelvic area and knowledge of the mechanisms of chronic pain. To ensure best possible assessment and treatment of these women it ... -
Adolescent self-harm and suicidal behavior and young adult outcomes in indigenous and non-indigenous people
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-18)The aim of this study was to examine the associations between self-harm and suicidal behavior in indigenous Sami and non-Sami adolescents and mental health and social outcomes in young adulthood. Data were obtained by linking the Norwegian Patient Registry (2008–2012), the National Insurance Registry (2003–2013), and the Norwegian Arctic Adolescent Health Study, a school-based survey inviting all ... -
The Impact of Cytokines on the Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-15)<i>Introduction</i>: Systemic lupus erythematosus (SLE) reduces the health-related quality of life (HRQoL), even during periods of disease quiescence. We investigated whether subclinical inflammation as reflected by cytokine levels is linked with reduced HRQoL. Methods: A cross-sectional study of SLE patients (<i>n</i> = 52, mean age 47.3, 86.5% female) who completed a Short Form Health Survey-36 ... -
Implementation of new guidelines in the prehospital services: a nationwide survey of Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)<i>Background</i> - A debate regarding the potential harmful effects of rigid neck collar and backboard usage among prehospital and hospital care providers in Norway provoked the development of an evidence-based guideline. “The Norwegian guideline for the prehospital management of adult trauma patients with potential spinal injury” was developed with rigorous scientific methods and published in ...