Now showing items 61-80 of 34986

    • FKRP-related limb-girdle muscular dystrophy R9 in Norway – Studies of epidemiology, natural history, and relationships with health-related quality of life and sleep 

      Jensen, Synnøve (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      <p><i>Background/aims:</i> Limb-girdle muscular dystrophy R9 (LGMDR9) is a rare autosomal recessive muscle disease caused by mutations in the fukutin-related protein gene, FKRP. The prevalence is higher in northern European populations, where it is closely associated with the FKRP c.826CA allele. This work aims to study the epidemiology of LGMDR9 in Norway, natural history, and relationships with ...
    • The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy 

      Egeland, Eivind Valen; Vasiliauskaite, Kotryna; Skourti, Eleni; Øy, Geir Frode; Pettersen, Solveig; Pandya, Abhilash D.; Dahle, Maria A.; Haugen, Mads; Kristian, Alexandr; Nakken, Sigve; Engebråten, Olav; Mælandsmo, Gunhild Mari; Prasmickaite, Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)
      BACKGROUND: Resistance to chemotherapy, combined with heterogeneity among resistant tumors, represents a significant challenge in the clinical management of triple negative breast cancer (TNBC). By dissecting molecular pathways associated with treatment resistance, we sought to define patient sub-groups and actionable targets for next-line treatment.<p> <p>METHODS: Bulk RNA sequencing and reverse ...
    • Holocene summer temperature reconstruction from plant sedaDNA and chironomids from the northern boreal forest 

      Mayfield, Roseanna J.; Rijal, Dilli Prasad; Heintzman, Peter D.; Langdon, Peter G.; Karger, Dirk N.; Brown, Antony Gavin; Alsos, Inger Greve (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-30)
      Climate-induced ecotonal shifts are expected to occur in the (sub)arctic and boreal zones in the coming decades. Understanding how these ecosystems have previously responded to climate change can provide greater insight into how ecosystems may develop under existing and future pressures. Here we present a Holocene record from Lake Horntjernet, a lake on the northern edge of the boreal forest in ...
    • Factors Associated With Prescription of Systemic Therapy in Real-world Patients With Metastatic Renal Cell Cancer Managed in a Rural Region 

      Nieder, Carsten; Stanisavljevic, Luka; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-03)
      Background/Aim: Numerous new treatment options have been approved for metastatic renal cell carcinoma (mRCC) in the last decade. Nevertheless, not all patients receive systemic therapy. Certain patients present with very advanced disease, poor Eastern Cooperative Oncology Group performance status (ECOG PS), or severe comorbidity, i.e. factors that lead oncologists to prefer best supportive ...
    • Efficient and sustainable: innovative pot design for a Mediterranean small-scale fishery 

      Virgili, Massimo; Petetta, Andrea; Herrmann, Bent; Cerbule, Kristine; Guicciardi, Stefano; Li Veli, Daniel; Barone, Giulio; Lucchetti, Alessandro (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-28)
      Pots are traditional fishing gear type largely employed in Mediterranean Small Scale Fisheries (SSFs). Their often higher species selectivity and catch quality compared to other gear types such as passive set nets or trawls are appealing characteristics for reducing the impact on benthic communities and diversifying fishing effort in the region. Despite this, in some SSFs, pots are still rarely used ...
    • Exploring Heat Transfer in Freezing Supercooled Water Droplet through High-Speed Infrared Thermography 

      Khawaja, Hassan Abbas; Keshavarzi, Samaneh; Adeel, Yousuf; Muhammed, Manaf; Virk, Muhammad Shakeel; Harvey, Derek; Momen, Gelareh (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-07)
      This study explores the intricate heat transfer dynamics and thermographic patterns during the phase change from supercooled liquid water to ice. Using high-resolution, high-speed infrared thermography, real-time temperature data were captured during the freezing process. The resulting temperature profiles reveal critical insights into the freezing dynamics, particularly highlighting the rapid ...
    • How Do Pharmacists Distribute Their Work Time during a Clinical Intervention Trial?—A Time and Motion Study 

      Holis, Renata Vesela; Elenjord, Renate; Lehnbom, Elin Christina; Andersen, Sigrid; Fagerli, Marie; Johnsgård, Tine; Zahl-Holmstad, Birgitte; Svendsen, Kristian; Waaseth, Marit; Skjold, frode; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-09)
      Emergency departments (EDs) handle urgent medical needs for a diverse population. Medication errors and adverse drug events pose safety risks in the ED. Clinical pharmacists, experts in medication use, play a crucial role in identifying and optimizing medication therapy. The aim of this study was to investigate how clinical pharmacists introduced into the ED interdisciplinary teams distribute ...
    • Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial 

      Madanhire, Tafadzwa; McHugh, Grace; Simms, Victoria; Ngwira, Lucky; Gonzalez-Martinez, Carmen; Semphere, Robina; Moyo, Brewster; Calderwood, Claire; Nicol, Mark; Bandason, Tsitsi; Odland, Jon Øyvind; Rehman, Andrea M.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-12)
      Background - Chronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has both antimicrobial and anti-inflammatory effects and has been effective in improving lung function in a variety of lung diseases. We investigated lung function trajectories among CWH with CLD on ART enrolled in a randomized controlled trial of ...
    • Acute responses to a potentiation warm-up protocol on sprint and change of direction in female football players: a randomized controlled study 

      Zylberberg, Tomás; Martins, Ricardo; Pettersen, Svein Arne; Afonso, José; Matias Do Vale Baptista, Ivan Andre (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-12)
      Objectives To evaluate the acute effect of exposure to a potentiation warm-up protocol compared to a usual warm-up program. <p>Design Randomized parallel control trial. <p>Setting Synthetic grass in the club’s facilities (Portugal). Participants Seventeen female football players (age: 23.9±3.9 years), were randomly allocated to a control (n=8) and an experimental group (n=9). To allocate the ...
    • Sámi community perspectives on the COVID-19 pandemic: a mixed methods case study in Arctic Sweden 

      Stoor, Jon Petter Anders; Sedholm, Oscar; San Sebastián, Miguel; Nilsson, Lena Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-25)
      The COVID-19 pandemic posed a grave threat not only to Indigenous people’s health and well-being, but also to Indigenous communities and societies. This applies also to the Indigenous peoples of the Arctic, where unintentional effects of public health actions to mitigate the spread of virus may have long-lasting effects on vulnerable communities. This study aim was to identify and describe Sámi ...
    • Functionally impaired children and their caregivers: A study in a clinical neuropaediatric setting on validity and usefulness of screening instruments completed by caregivers, and caregivers' satisfaction with neuropaediatric assessment 

      Kjærandsen, Katarina Maria Smejda (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      This dissertation is based on a naturalistic multicentre study in the context of an interdisciplinary assessment in neuropediatric clinics. The main objective was to expand knowledge about this assessment, focusing primarily on the role of screening instruments completed by caregivers and their satisfaction with the assessment. The validity and usefulness of screening tools for parental mental health ...
    • The emerging picture of a diverse deep Arctic Ocean seafloor: From habitats to ecosystems 

      Ramirez-Llodra, Eva; Meyer, Heidi Kristina; Bluhm, Bodil Annikki Ulla Barbro; Brix, Saskia; Brandt, Angelika; Dannheim, Jennifer; Downey, Rachel V.; Egilsdottir, Hrönn; Eilertsen, Mari Heggernes; Gaudron, Sylvie M.; Gebruk, Anna; Golikov, Alexey V.; Hasemann, Christiane; Hilário, Ana; Jørgensen, Lis Lindal; Kaiser, Stefanie; Korfhage, Severin A.; Kürzel, Karlotta; Lörz, Anne-Nina; Buhl-Mortensen, Pål; Olafsdottir, Steinunn H.; Piepenburg, Dieter; Purser, Autun; Ribeiro, Pedro A; Sen, Arunima; Soltwedel, Thomas; Stratmann, Tanja; Steger, Jan; Svavarsson, Jörundur; Tandberg, Anne Helene S.; Taylor, James; Theising, Franziska I; Uhlir, Carolin; Waller, Rhian G.; Xavier, Joana R.; Zhulay, Irina; Saaedi, Hanieh (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-04)
      Interest in the deep Arctic Ocean is rapidly increasing from governments, policy makers, industry, researchers, and conservation groups, accentuated by the growing accessibility of this remote region by surface vessel traffic. In this review, our goal is to provide an updated taxonomic inventory of benthic taxa known to occur in the deep Arctic Ocean and relate this inventory to habitat diversity. ...
    • Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease 

      Hovd, Aud-Malin Karlsson; Nayar, Saba; Smith, Charlotte G; Kanapathippilai, Premasany; Iannizzotto, Valentina; Barone, Francesca; Fenton, Kristin Andreassen; Pedersen, Hege Lynum (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)
      Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression. Here, we investigated the dynamics of tissue resident macrophages in the induction and expansion of salivary gland TLS. We induced Sjögren’s disease by ...
    • Benthic remineralization under future Arctic conditions and evaluating the potential for changes in carbon sequestration in warming sediments 

      Sen, Arunima; Jordà Molina, Èric; Ricardo de Freitas, Thaise; Hess, Silvia; Reiss, Henning; Bluhm, Bodil Annikki Ulla Barbro; Renaud, Paul Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-07)
      Benthic (seafloor) remineralization of organic material determines the fate of carbon in the ocean and its sequestration. Bottom water temperature and labile carbon supply to the seafloor are expected to increase in a warming Arctic and correspondingly, benthic remineralization rates. We provide some of the first experimental data on the response of sediment oxygen demand (SOD), an established proxy ...
    • Exploring views among Norwegian Sámi regarding gambling and gambling treatment 

      Devold, Marte Reikvam; Spein, Anna Rita; Barua, Pia; Indset, Marie Pedersen; Syvertsen, Andre; Pallesen, Ståle (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-19)
      Aim: To explore gambling in the indigenous Sámi culture by studying thoughts, ideas and attitudes towards gambling among Sámi and people living in majority Sámi areas with knowledge of the culture. <p> <p>Methods: The topic was investigated in an inductive thematic analysis of semi-structured interviews with 14 people (n = 13 self-reported Sámi ethnicity). <p> <p>Results: The majority of the ...
    • Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries 

      Deschasaux-Tanguy, Mélanie; Huybrechts, Inge; Julia, Chantal; Hercberg, Serge; Sarda, Barthélémy; Fialon, Morgane; Arnault, Nathalie; Srour, Bernard; Kesse-Guyot, Emmanuelle; Fezeu, Léopold K.; Biessy, Carine; Casagrande, Corinne; Hemon, Bertrand; Weiderpass Vainio, Elisabete; Pinho, Maria G.M.; Murphy, Neil; Freisling, Heinz; Ferrari, Pietro; Tjønneland, Anne; Nielsen Petersen, Kristina Elin; Katzke, Verena; Kaaks, Rudolf; Schulze, Matthias B.; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Ricceri, Fulvio; Verschuren, W.M.Monique; Boer, Jolanda M.A.; van der Schouw, Yvonne T.; Skeie, Guri; Agudo, Antonio; Molina-Montes, Esther; Huerta, José María; Moreno-Iribas, Conchi; Ericson, Ulrika; Sonestedt, Emily; Strid, Anna; Oskarsson, Viktor; Tong, Tammy Y.N.; Heath, Alicia K.; Aglago, Elom K.; Danesh, John; Riboli, Elio; Gunter, Marc J.; Touvier, Mathilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11)
      Background - Nutri-Score is a scientifically validated 5-color front-of-pack nutrition label reflecting the nutrient profile of foods. It has been implemented in several European countries on a voluntary basis, pending the revision of the European labeling regulation. Hence, scientific evidence is needed regarding the ability of the nutrient profile underlying the Nutri-Score (uNS-NPS, 2023-updated ...
    • Characterizing humpback whale behavior along the North-Norwegian coast 

      Ytterhus Utengen, Ingvild; Vogel, Emma Frances; Biuw, Martin; Van Ruiten, Meghan; Rikardsen, Audun Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-09)
      Background - Studying movement patterns of individual animals over time can give insight into how they interact with the environment and optimize foraging strategies. Humpback whales (Megaptera novaeangliae) undertake long seasonal migrations between feeding areas in polar regions and breeding grounds in tropical areas. During the last decade, several individuals have had up to a 3-month stop-over ...
    • Looks at what isn't there: eye movements on a blank screen when processing negation in a first and a second language 

      Vanek, Norbert; Matić Škorić, Ana; Kosutar, Sara; Matějka, Štěpán; Stone, Kate Stone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)
      Is negation more difficult to process than affirmation? If it is, does processing negation in a second language (L2) compound the difficulty compared to the first language (L1)? This article addresses the issues of difficulties in processing different types of negation in the L1 and L2 by looking at the differences in the ways in which comprehenders anticipate upcoming visual information during ...
    • Theoretical Underpinnings of the Political Priorities of Municipal Healthcare Services in Norway. How a Rawlsian Heuristic Can Aid Political Decision-Making in Municipal Healthcare Services 

      Rød, Daniel Andre Voll; Stensen, Vegard; Krane, Martin Sollund (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-11)
      This paper aims to discuss the current criteria for municipal priorities in municipal healthcare services in Norway in light of major theories from political philosophy on social justice, such as John Rawlsʼs theory of justice and utilitarianism. Our first goal is to show that perspectives from political philosophy could prove useful for increasing our understanding of the current priority-setting ...
    • Tildelingsfunksjonens rolle i prioritering av kommunale tjenester 

      Angelsen, Villy; Hartviksen, Trude Anita; Solbakken, Rita; Holm, Solrun Gjertine (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-11)
      Bakgrunn: Den demografiske utviklingen, med økt antall og andel eldre, krever strengere prioritering av ressurser innenfor kommunale helse- og omsorgstjenester. Tildelingsfunksjonen har en viktig rolle i prioriteringen av tjenester på faglig nivå. Med utgangspunkt i teori om styringsmodeller i offentlig sektor belyser studien forskningsspørsmålet: Innenfor hvilke organisatoriske rammer skjer ...